SIB-1553A

{{Chembox | ImageFile = SIB-1553A.svg | ImageSize = 200px | ImageAlt = | IUPACName = (R/S)-4-{[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio}phenol hydrochloride | OtherNames = |Section1=! colspan=2 style="background: #f8eaba; text-align: center;" |Identifiers

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CAS Number

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191611-76-4^Y

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3D model (JSmol)

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Interactive image

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CompTox Dashboard (EPA)

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DTXSID70940803

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SMILES

OC1=CC=C(SCCC2CCCN2C)C=C1

|- |Section2=! colspan=2 style="background: #f8eaba; text-align: center;" |Properties

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Chemical formula

| C₁₃H₁₉NOS

|- | Molar mass

| 237.36 g·mol⁻¹

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SIB-1553A is a nicotinic acetylcholine receptor agonist that is selective for receptors with a β₄ subunit. Administration of SIB-1553A improved memory and attention in a Parkinson's disease model.^[1]

References

^ Schneider, JS (July 2003). "The Subtype-Selective Nicotinic Acetylcholine Receptor Agonist SIB-1553A Improves Both Attention and Memory Components of a Spatial Working Memory Task in Chronic Low Dose 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Monkeys". Journal of Pharmacology and Experimental Therapeutics. 306 (1): 401–6. doi:10.1124/jpet.103.051912. PMID 12721323. {{cite journal}}: |access-date= requires |url= (help)

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[Schneider-1] Schneider, JS (July 2003). "The Subtype-Selective Nicotinic Acetylcholine Receptor Agonist SIB-1553A Improves Both Attention and Memory Components of a Spatial Working Memory Task in Chronic Low Dose 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Monkeys". Journal of Pharmacology and Experimental Therapeutics. 306 (1): 401–6. doi:10.1124/jpet.103.051912. PMID 12721323. {{cite journal}}: |access-date= requires |url= (help)

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