SMC4

SMC4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4U4P
Identifiers
Aliases	SMC4, CAP-C, CAPC, SMC-4, SMC4L1, hCAP-C, structural maintenance of chromosomes 4
External IDs	OMIM: 605575; MGI: 1917349; HomoloGene: 4015; GeneCards: SMC4; OMA:SMC4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q25.33 Start 160,399,274 bp End 160,434,954 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 E1 Start 68,912,071 bp End 68,941,956 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence trabecular bone testicle bone marrow cells gonad right testis Achilles tendon left testis right coronary artery Top expressed in human fetus primary oocyte tibiofemoral joint fetal liver hematopoietic progenitor cell spermatocyte thymus tail of embryo maxillary prominence migratory enteric neural crest cell dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein heterodimerization activity nucleotide binding protein binding ATP binding single-stranded DNA binding Cellular component chromosome nucleus condensin complex nucleoplasm cytoplasm cytosol nuclear speck Biological process mitotic sister chromatid segregation meiotic chromosome segregation cell division cell cycle kinetochore organization mitotic chromosome condensation meiotic chromosome condensation chromosome condensation chromosome organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10051 70099 Ensembl ENSG00000113810 ENSMUSG00000034349 UniProt Q9NTJ3 Q8CG47 RefSeq (mRNA) NM_001002799 NM_001002800 NM_001288753 NM_005496 NM_133786 NM_001356976 RefSeq (protein) NP_001002800 NP_001275682 NP_005487 NP_598547 NP_001343905 Location (UCSC) Chr 3: 160.4 – 160.43 Mb Chr 3: 68.91 – 68.94 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Structural maintenance of chromosomes protein 4 (SMC-4) also known as chromosome-associated polypeptide C (CAP-C) or XCAP-C homolog is a protein that in humans is encoded by the SMC4 gene. SMC-4 is a core subunit of condensin I and II, large protein complexes involved in chromosome condensation.

Further reading

• Hirano T (2002). "The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion, and repair". Genes Dev. 16 (4): 399–414. doi:10.1101/gad.955102. PMID 11850403.
• Ball Jr AR, Yokomori K (2001). "The structural maintenance of chromosomes (SMC) family of proteins in mammals". Chromosome Res. 9 (2): 85–96. doi:10.1023/A:1009287518015. PMID 11321372.
• Ham MF, Takakuwa T, Rahadiani N, et al. (2007). "Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma". Cancer Sci. 98 (7): 1041–7. doi:10.1111/j.1349-7006.2007.00500.x. PMID 17488335.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Geiman TM, Sankpal UT, Robertson AK, et al. (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Res. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Kimura K, Cuvier O, Hirano T (2001). "Chromosome condensation by a human condensin complex in Xenopus egg extracts". J. Biol. Chem. 276 (8): 5417–20. doi:10.1074/jbc.C000873200. PMID 11136719.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Schmiesing JA, Gregson HC, Zhou S, Yokomori K (2000). "A Human Condensin Complex Containing hCAP-C–hCAP-E and CNAP1, a Homolog of Xenopus XCAP-D2, Colocalizes with Phosphorylated Histone H3 during the Early Stage of Mitotic Chromosome Condensation". Mol. Cell. Biol. 20 (18): 6996–7006. doi:10.1128/MCB.20.18.6996-7006.2000. PMC 88774. PMID 10958694.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links

• SMC4 human gene location in the UCSC Genome Browser.
• SMC4 human gene details in the UCSC Genome Browser.