TRNT1

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TRNT1
Protein TRNT1 PDB 1ou5.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TRNT1, CCA1, MtCCA, CGI-47, SIFD, tRNA nucleotidyl transferase 1, RPEM
External IDs MGI: 1917297 HomoloGene: 9333 GeneCards: TRNT1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001302946
NM_016000
NM_182916

NM_001242358
NM_001242360
NM_027296

RefSeq (protein)

NP_001289875
NP_886552

Location (UCSC) Chr 3: 3.13 – 3.15 Mb Chr 6: 106.77 – 106.78 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

tRNA-nucleotidyltransferase 1, is an enzyme that in humans is encoded by the TRNT1 gene.[3][4][5] This enzyme adds the nucleotide sequence CCA to the 3' end of tRNA, using ATP and CTP as substrates. The sequence creates the binding site for an amino acid.[6]


References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876Freely accessible. PMID 10810093. 
  4. ^ Nagaike T, Suzuki T, Tomari Y, Takemoto-Hori C, Negayama F, Watanabe K, Ueda T (Oct 2001). "Identification and characterization of mammalian mitochondrial tRNA nucleotidyltransferases". J Biol Chem. 276 (43): 40041–9. doi:10.1074/jbc.M106202200. PMID 11504732. 
  5. ^ "Entrez Gene: TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1". 
  6. ^ Lizano E, Scheibe M, Rammelt C, Betat H, Mörl M (May 2008). "A comparative analysis of CCA-adding enzymes from human and E. coli: differences in CCA addition and tRNA 3'-end repair". Biochimie. 90 (5): 762–72. doi:10.1016/j.biochi.2007.12.007. PMID 18226598. 

Further reading[edit]