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Growth differentiation factor 1
Symbols GDF1 ; DORV; DTGA3
External IDs OMIM602880 MGI95683 HomoloGene105644 GeneCards: GDF1 Gene
Species Human Mouse
Entrez 2657 14559
Ensembl ENSG00000130283 ENSMUSG00000055694
UniProt P27539 P20863
RefSeq (mRNA) NM_001492 NM_001163282
RefSeq (protein) NP_001483 NP_001156754
Location (UCSC) Chr 19:
18.98 – 19.01 Mb
Chr 8:
70.32 – 70.33 Mb
PubMed search [1] [2]

Growth differentiation factor-1 (GDF1) is a protein that in humans is encoded by the GDF1 gene.[1]

GDF1 belongs to the transforming growth factor beta superfamily that has a role in left-right patterning and mesoderm induction during embryonic development.[2] It is found in the brain, spinal cord and peripheral nerves of embryos.[1][2]


  1. ^ a b Lee SJ (May 1991). "Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure". Proc. Natl. Acad. Sci. U.S.A. 88 (10): 4250–4. doi:10.1073/pnas.88.10.4250. PMC 51636. PMID 2034669. 
  2. ^ a b Rankin CT, Bunton T, Lawler AM, Lee SJ (March 2000). "Regulation of left-right patterning in mice by growth/differentiation factor-1". Nat. Genet. 24 (3): 262–5. doi:10.1038/73472. PMID 10700179. 

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