ACVR2A

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Activin A receptor, type IIA
Protein ACVR2A PDB 1bte.png
PDB rendering based on 1bte.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ACVR2A ; ACTRII; ACVR2
External IDs OMIM102581 MGI102806 HomoloGene20391 ChEMBL: 5616 GeneCards: ACVR2A Gene
EC number 2.7.11.30
Orthologs
Species Human Mouse
Entrez 92 11480
Ensembl ENSG00000121989 ENSMUSG00000052155
UniProt P27037 P27038
RefSeq (mRNA) NM_001616 NM_007396
RefSeq (protein) NP_001607 NP_031422
Location (UCSC) Chr 2:
148.6 – 148.69 Mb
Chr 2:
48.81 – 48.9 Mb
PubMed search [1] [2]

Activin receptor type-2A is a protein that in humans is encoded by the ACVR2A gene.[1][2][3] ACVR2A is an activin type 2 receptor.

Function[edit]

This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.[3]

Interactions[edit]

ACVR2A has been shown to interact with:


References[edit]

  1. ^ Donaldson CJ, Mathews LS, Vale WW (May 1992). "Molecular cloning and binding properties of the human type II activin receptor". Biochem Biophys Res Commun 184 (1): 310–316. doi:10.1016/0006-291X(92)91194-U. PMID 1314589. 
  2. ^ Bondestam J, Horelli-Kuitunen N, Hilden K, Ritvos O, Aaltonen J (April 2000). "Assignment of ACVR2 and ACVR2B the human activin receptor type II and IIB genes to chromosome bands 2q22.2→q23.3 and 3p22 and the human follistatin gene (FST) to chromosome 5q11.2 by FISH". Cytogenet Cell Genet 87 (3–4): 219–220. doi:10.1159/000015429. PMID 10702675. 
  3. ^ a b "Entrez Gene: ACVR2A activin A receptor, type IIA". 
  4. ^ Lebrun JJ, Takabe K, Chen Y, Vale W (January 1999). "Roles of pathway-specific and inhibitory Smads in activin receptor signaling". Mol. Endocrinol. 13 (1): 15–23. doi:10.1210/mend.13.1.0218. PMID 9892009. 
  5. ^ De Winter JP, De Vries CJ, Van Achterberg TA, Ameerun RF, Feijen A, Sugino H, De Waele P, Huylebroeck D, Verschueren K, Van Den Eijden-Van Raaij AJ (May 1996). "Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors". Exp. Cell Res. 224 (2): 323–34. doi:10.1006/excr.1996.0142. PMID 8612709. 
  6. ^ Lewis KA, Gray PC, Blount AL, MacConell LA, Wiater E, Bilezikjian LM, Vale W (March 2000). "Betaglycan binds inhibin and can mediate functional antagonism of activin signalling". Nature 404 (6776): 411–4. doi:10.1038/35006129. PMID 10746731. 
  7. ^ Martens JW, de Winter JP, Timmerman MA, McLuskey A, van Schaik RH, Themmen AP, de Jong FH (July 1997). "Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells". Endocrinology 138 (7): 2928–36. doi:10.1210/endo.138.7.5250. PMID 9202237. 
  8. ^ Tsuchida K, Nakatani M, Matsuzaki T, Yamakawa N, Liu Z, Bao Y, Arai KY, Murakami T, Takehara Y, Kurisaki A, Sugino H (October 2004). "Novel factors in regulation of activin signaling". Mol. Cell. Endocrinol. 225 (1-2): 1–8. doi:10.1016/j.mce.2004.02.006. PMID 15451561. 
  9. ^ Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H (May 2002). "Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway". J. Biol. Chem. 277 (21): 19008–18. doi:10.1074/jbc.M112472200. PMID 11882656. 

Further reading[edit]