GDF10

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Growth differentiation factor 10
Identifiers
Symbols GDF10 ; BMP-3b; BMP3B
External IDs OMIM601361 MGI95684 HomoloGene3640 GeneCards: GDF10 Gene
Orthologs
Species Human Mouse
Entrez 2662 14560
Ensembl ENSG00000107623 ENSMUSG00000021943
UniProt P55107 P97737
RefSeq (mRNA) NM_004962 NM_145741
RefSeq (protein) NP_004953 NP_665684
Location (UCSC) Chr 10:
48.43 – 48.44 Mb
Chr 14:
33.92 – 33.94 Mb
PubMed search [1] [2]

Growth differentiation factor 10 (GDF10) also known as bone morphogenetic protein 3B (BMP-3B) is a protein that in humans is encoded by the GDF10 gene.[1]

GDF10 belongs to the transforming growth factor beta superfamily that is closely related to bone morphogenetic protein-3 (BMP3). It plays a role in head formation and may have multiple roles in skeletal morphogenesis.[2][1] GDF10 is also known as BMP-3b, with GDF10 and BMP3 regarded as a separate subgroup within the TGF-beta superfamily.[1]

In mice, GDF10 mRNA is abundant in the brain, inner ear, uterus, prostate, neural tissues, blood vessels and adipose tissue with low expression in spleen and liver. It is also present in bone of both adults and neonatal mice.[1] Human GDF10 mRNA is found in the cochlea and lung of foetuses, and in testis, retina, pineal gland, and other neural tissues of adults.[3]

References[edit]

  1. ^ a b c d Cunningham NS, Jenkins NA, Gilbert DJ, Copeland NG, Reddi AH, Lee SJ (1995). "Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein-3". Growth Factors 12 (2): 99–109. doi:10.3109/08977199509028956. PMID 8679252. 
  2. ^ Hino J, Kangawa K, Matsuo H, Nohno T, Nishimatsu S (2004). "Bone morphogenetic protein-3 family members and their biological functions". Front Biosci 9: 1520–9. doi:10.2741/1355. PMID 14977563. 
  3. ^ Katoh Y, Katoh M (2006). "Comparative integromics on BMP/GDF family". Int J Mol Med 17 (5): 951–5. PMID 16596286. 


Further reading[edit]