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Updating {{drugbox}} (no changed fields - added verified revid - updated 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'ChEBI_Ref') per Chem/Drugbox validation (report errors or [[user talk:CheMoB
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| verifiedrevid = 447573840
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| verifiedrevid = 437176484
| IUPAC_name = 4-​(2-​fluorophenyl)-​1,3,8-​trimethyl-​6,8-​dihydropyrazolo[3,4-''e'']​[1,4]diazepin-​7(1''H'')-​one
| IUPAC_name = 4-​(2-​fluorophenyl)-​1,3,8-​trimethyl-​6,8-​dihydropyrazolo[3,4-''e'']​[1,4]diazepin-​7(1''H'')-​one
| image = Zolazepam.svg
| image = Zolazepam.svg

Revision as of 20:17, 10 September 2011

Zolazepam
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
  • none
Identifiers
  • 4-​(2-​fluorophenyl)-​1,3,8-​trimethyl-​6,8-​dihydropyrazolo[3,4-e]​[1,4]diazepin-​7(1H)-​one
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.118.306 Edit this at Wikidata
Chemical and physical data
FormulaC15H15FN4O
Molar mass286.304 g·mol−1
3D model (JSmol)
  • Fc3ccccc3C/1=N/CC(=O)N(c2c\1c(nn2C)C)C
  • InChI=1S/C15H15FN4O/c1-9-13-14(10-6-4-5-7-11(10)16)17-8-12(21)19(2)15(13)20(3)18-9/h4-7H,8H2,1-3H3 checkY
  • Key:GDSCFOSHSOWNDL-UHFFFAOYSA-N checkY
  (verify)

Zolazepam (Flupyrazapon) is a pyrazolodiazepinone derivative structurally related to the benzodiazepine drugs, which is used as an anaesthetic for a wide range of animals in veterinary medicine. Zolazepam is usually administered in combination with other drugs such as the NMDA antagonist tiletamine or the alpha-2 adrenergic receptor agonist xylazine, depending on what purpose it is being used for.

Zolazepam was developed by Horace A. de Wald and Donald E. Butler for Parke Davis and was the result of a very detailed analysis of the benzodiazepine structure (US Patent 3,558,605 filed in 1969).

Zolazepam, in combination with tiletamine, has been used in the tranquilization of wild animals, such as gorillas and polar bears, and has been found to be in terms of reduced side-effects superior to ketamine.[1][2]

Dewald, Horace A.; Lobbestael, Sandra; Butler, Donald E. (1977). "Pyrazolodiazepines. 2. 4-Aryl-1,3-dialkyl-6,8-dihydropyrazolo[3,4-e][1,4]diazepin-7(1H)-ones as antianxiety and anticonvulsant agents". Journal of Medicinal Chemistry. 20 (12): 1562. doi:10.1021/jm00222a005. PMID 22748.

See also

References

  1. ^ Sleeman JM (2000). "Field anesthesia of free-living mountain gorillas (Gorilla gorilla beringei) from the Virunga Volcano region, Central Africa". Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 31 (1): 9–14. PMID 10884117. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)
  2. ^ Cattet MR (1999). "Anesthesia of polar bears (Ursus maritimus) with zolazepam-tiletamine, medetomidine-ketamine, and medetomidine-zolazepam-tiletamine". Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 30 (3): 354–60. PMID 10572857. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)


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