Bitter orange: Difference between revisions
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|familia = [[Rutaceae]] |
|familia = [[Rutaceae]] |
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|genus = ''[[Citrus]]'' |
|genus = ''[[Citrus]]'' |
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|species = '''''C. aurantium''''' |
|species = '''''C. × aurantium''''' |
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|binomial = ''Citrus aurantium'' |
|binomial = '' Citrus × aurantium'' |
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|binomial_authority = [[Carl Linnaeus|L.]], 1753<ref name="GRIN">{{cite web |url=http://www.ars-grin.gov/cgi-bin/npgs/html/taxon.pl?10684 |title=''Citrus aurantium'' L. |work=Germplasm Resources Information Network |publisher=United States Department of Agriculture |date=1999-12-17 |accessdate=2010-01-05}}</ref> |
|binomial_authority = [[Carl Linnaeus|L.]], 1753<ref name="GRIN">{{cite web |url=http://www.ars-grin.gov/cgi-bin/npgs/html/taxon.pl?10684 |title=''Citrus × aurantium'' L. |work=Germplasm Resources Information Network |publisher=United States Department of Agriculture |date=1999-12-17 |accessdate=2010-01-05}}</ref> |
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The name "'''bitter orange'''", also known as '''Seville orange''', '''sour orange''', '''bigarade orange''', and '''marmalade orange''', refers to a [[citrus]] tree ('''''Citrus aurantium''''') and its fruit. Many varieties of bitter orange are utilized for their [[essential oil]], which is used in [[perfume]] and as a [[flavoring]]. Bitter orange is also employed in [[Herbalism|herbal medicine]] as a [[stimulant]] and [[appetite suppressant]]. Slivers of the [[Peel (fruit)|rind]] are used to give [[marmalade]] its characteristic bitter taste.{{Citation needed|date=May 2011}} They are also more resiliant than the regular orange and have been known to survive hurricanes, where as regular oranges do not. |
The name "'''bitter orange'''", also known as '''Seville orange''', '''sour orange''', '''bigarade orange''', and '''marmalade orange''', refers to a [[citrus]] tree ('''''Citrus × aurantium''''') and its fruit. Many varieties of bitter orange are utilized for their [[essential oil]], which is used in [[perfume]] and as a [[flavoring]]. Bitter orange is also employed in [[Herbalism|herbal medicine]] as a [[stimulant]] and [[appetite suppressant]]. Slivers of the [[Peel (fruit)|rind]] are used to give [[marmalade]] its characteristic bitter taste.{{Citation needed|date=May 2011}} They are also more resiliant than the regular orange and have been known to survive hurricanes, where as regular oranges do not. |
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After the [[U.S. Food and Drug Administration]] banned the herbal stimulant [[ephedra]], manufacturers substituted bitter orange in many herbal [[Anti-obesity medication|weight-loss products]],<ref name="nyt">{{cite news | publisher = ''[[New York Times]]'' |url = http://www.nytimes.com/2005/10/11/health/policy/11cons.html | title = Bitter Orange Under Scrutiny as New Ephedra | last = Duenwald | first = Mary | date = 2005-10-11 | accessdate = 2008-11-03}}</ref> despite similar concerns about potential serious side effects and lack of effectiveness.<ref name="sharpe"/><ref name="nccam"/> In a recent article by the publication ''[[Consumer Reports]]'', it was furthermore reported that use of bitter orange may be associated with "fainting, heart-rhythm disorders, heart attack, stroke, [and] death".<ref name="CR2010list">"Dangerous Supplements: Twelve Supplements You Should Avoid" ''Consumer Reports Magazine'', September 2010 http://www.consumerreports.org/cro/magazine-archive/2010/september/health/dangerous-supplements/supplements-to-avoid/index.htm</ref> |
After the [[U.S. Food and Drug Administration]] banned the herbal stimulant [[ephedra]], manufacturers substituted bitter orange in many herbal [[Anti-obesity medication|weight-loss products]],<ref name="nyt">{{cite news | publisher = ''[[New York Times]]'' |url = http://www.nytimes.com/2005/10/11/health/policy/11cons.html | title = Bitter Orange Under Scrutiny as New Ephedra | last = Duenwald | first = Mary | date = 2005-10-11 | accessdate = 2008-11-03}}</ref> despite similar concerns about potential serious side effects and lack of effectiveness.<ref name="sharpe"/><ref name="nccam"/> In a recent article by the publication ''[[Consumer Reports]]'', it was furthermore reported that use of bitter orange may be associated with "fainting, heart-rhythm disorders, heart attack, stroke, [and] death".<ref name="CR2010list">"Dangerous Supplements: Twelve Supplements You Should Avoid" ''Consumer Reports Magazine'', September 2010 http://www.consumerreports.org/cro/magazine-archive/2010/september/health/dangerous-supplements/supplements-to-avoid/index.htm</ref> |
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Following bans on the herbal stimulant [[ephedra]] in the [[United States|U.S.]], [[Canada]], and elsewhere, bitter orange has been substituted into "ephedra-free" herbal weight-loss products by [[dietary supplement]] manufacturers.<ref name="nyt"/> While bitter orange has not undergone formal safety testing, it can cause the same spectrum of [[adverse events]] as ephedra.<ref name="jordan">{{cite journal |author=Jordan S, Murty M, Pilon K |title=Products containing bitter orange or synephrine: suspected cardiovascular adverse reactions |journal=[[Canadian Medical Association Journal]] |volume=171 |issue=8 |pages=993–4 |year=2004 |month=October |pmid=15497209 |doi= |url=http://www.cmaj.ca/cgi/pmidlookup?view=long&pmid=15497209 |format=}} {{dead link|date=May 2010}}</ref> [[Case report]]s have linked bitter orange supplements to [[stroke]]s,<ref>{{cite journal |author=Bouchard NC, Howland MA, Greller HA, Hoffman RS, Nelson LS |title=Ischemic stroke associated with use of an ephedra-free dietary supplement containing synephrine |journal=Mayo Clinic Proceedings |volume=80 |issue=4 |pages=541–5 |year=2005 |month=April |pmid=15819293 |doi= 10.4065/80.4.541|url=}}</ref><ref>{{cite journal |author=Holmes RO, Tavee J |title=Vasospasm and stroke attributable to ephedra-free xenadrine: case report |journal=[[Military Medicine (journal)|Military Medicine]] |volume=173 |issue=7 |pages=708–10 |year=2008 |month=July |pmid=18700609 |doi=}}</ref> [[angina]],<ref name="pmid18700609">{{cite journal |doi=10.4065/81.4.545 |author=Gange CA, Madias C, Felix-Getzik EM, Weintraub AR, Estes NA |title=Variant angina associated with bitter orange in a dietary supplement |journal=[[Mayo Clinic Proceedings]] |volume=81 |issue=4 |pages=545–8 |year=2006 |month=April |pmid=16610576 }}</ref> and [[ischemic colitis]].<ref>{{cite journal |author=Sultan S, Spector J, Mitchell RM |title=Ischemic colitis associated with use of a bitter orange-containing dietary weight-loss supplement |journal=Mayo Clinic Proceedings |volume=81 |issue=12 |pages=1630–1 |year=2006 |month=December |pmid=17165643 |doi= 10.4065/81.12.1630|url=}}</ref> |
Following bans on the herbal stimulant [[ephedra]] in the [[United States|U.S.]], [[Canada]], and elsewhere, bitter orange has been substituted into "ephedra-free" herbal weight-loss products by [[dietary supplement]] manufacturers.<ref name="nyt"/> While bitter orange has not undergone formal safety testing, it can cause the same spectrum of [[adverse events]] as ephedra.<ref name="jordan">{{cite journal |author=Jordan S, Murty M, Pilon K |title=Products containing bitter orange or synephrine: suspected cardiovascular adverse reactions |journal=[[Canadian Medical Association Journal]] |volume=171 |issue=8 |pages=993–4 |year=2004 |month=October |pmid=15497209 |doi= |url=http://www.cmaj.ca/cgi/pmidlookup?view=long&pmid=15497209 |format=}} {{dead link|date=May 2010}}</ref> [[Case report]]s have linked bitter orange supplements to [[stroke]]s,<ref>{{cite journal |author=Bouchard NC, Howland MA, Greller HA, Hoffman RS, Nelson LS |title=Ischemic stroke associated with use of an ephedra-free dietary supplement containing synephrine |journal=Mayo Clinic Proceedings |volume=80 |issue=4 |pages=541–5 |year=2005 |month=April |pmid=15819293 |doi= 10.4065/80.4.541|url=}}</ref><ref>{{cite journal |author=Holmes RO, Tavee J |title=Vasospasm and stroke attributable to ephedra-free xenadrine: case report |journal=[[Military Medicine (journal)|Military Medicine]] |volume=173 |issue=7 |pages=708–10 |year=2008 |month=July |pmid=18700609 |doi=}}</ref> [[angina]],<ref name="pmid18700609">{{cite journal |doi=10.4065/81.4.545 |author=Gange CA, Madias C, Felix-Getzik EM, Weintraub AR, Estes NA |title=Variant angina associated with bitter orange in a dietary supplement |journal=[[Mayo Clinic Proceedings]] |volume=81 |issue=4 |pages=545–8 |year=2006 |month=April |pmid=16610576 }}</ref> and [[ischemic colitis]].<ref>{{cite journal |author=Sultan S, Spector J, Mitchell RM |title=Ischemic colitis associated with use of a bitter orange-containing dietary weight-loss supplement |journal=Mayo Clinic Proceedings |volume=81 |issue=12 |pages=1630–1 |year=2006 |month=December |pmid=17165643 |doi= 10.4065/81.12.1630|url=}}</ref> |
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The [[National Center for Complementary and Alternative Medicine]] found that "there is currently little evidence that bitter orange is safer to use than ephedra."<ref name="nccam">{{cite web | publisher = [[National Center for Complementary and Alternative Medicine]] | title = Bitter Orange | url = http://nccam.nih.gov/health/bitterorange/ | date = April 2008 | accessdate = 2008-11-03}}</ref> There is no evidence that bitter orange is effective in promoting weight loss.<ref name="sharpe">{{cite journal |author=Sharpe PA, Granner ML, Conway JM, Ainsworth BE, Dobre M |title=Availability of weight-loss supplements: Results of an audit of retail outlets in a southeastern city |journal=Journal of the American Dietetic Association |volume=106 |issue=12 |pages=2045–51 |year=2006 |month=December |pmid=17126636 |doi=10.1016/j.jada.2006.09.014 |url=}}</ref> |
The [[National Center for Complementary and Alternative Medicine]] found that "there is currently little evidence that bitter orange is safer to use than ephedra."<ref name="nccam">{{cite web | publisher = [[National Center for Complementary and Alternative Medicine]] | title = Bitter Orange | url = http://nccam.nih.gov/health/bitterorange/ | date = April 2008 | accessdate = 2008-11-03}}</ref> There is no evidence that bitter orange is effective in promoting weight loss.<ref name="sharpe">{{cite journal |author=Sharpe PA, Granner ML, Conway JM, Ainsworth BE, Dobre M |title=Availability of weight-loss supplements: Results of an audit of retail outlets in a southeastern city |journal=Journal of the American Dietetic Association |volume=106 |issue=12 |pages=2045–51 |year=2006 |month=December |pmid=17126636 |doi=10.1016/j.jada.2006.09.014 |url=}}</ref> |
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Revision as of 23:13, 24 August 2011
- For the fruit known as "Chinese Bitter Orange," see Trifoliate orange.
| Citrus aurantium | |
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| Species: | C. × aurantium
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| Binomial name | |
| Citrus × aurantium | |
The name "bitter orange", also known as Seville orange, sour orange, bigarade orange, and marmalade orange, refers to a citrus tree (Citrus × aurantium) and its fruit. Many varieties of bitter orange are utilized for their essential oil, which is used in perfume and as a flavoring. Bitter orange is also employed in herbal medicine as a stimulant and appetite suppressant. Slivers of the rind are used to give marmalade its characteristic bitter taste.[citation needed] They are also more resiliant than the regular orange and have been known to survive hurricanes, where as regular oranges do not.
After the U.S. Food and Drug Administration banned the herbal stimulant ephedra, manufacturers substituted bitter orange in many herbal weight-loss products,[2] despite similar concerns about potential serious side effects and lack of effectiveness.[3][4] In a recent article by the publication Consumer Reports, it was furthermore reported that use of bitter orange may be associated with "fainting, heart-rhythm disorders, heart attack, stroke, [and] death".[5]
Varieties
- Citrus aurantium subsp. amara is a spiny evergreen tree native to southern Vietnam, but widely cultivated. It is used as grafting stock for citrus trees, in marmalade, and in liqueur like triple sec, Grand Marnier and Curaçao. It is also cultivated for the essential oil expressed from the fruit, and for neroli oil and orange flower water, which are distilled from the flowers.
- Seville orange (or bigarade) is a widely-known, particularly tart orange which is now grown throughout the Mediterranean region. It has a thick, dimpled skin, and is prized for making marmalade, being higher in pectin than the sweet orange, and therefore giving a better set and a higher yield. It is also used in compotes and for orange-flavored liqueurs. Once a year, oranges of this variety are collected from trees in Seville and shipped to Britain to be used in marmalade.[6] However, the fruit is rarely consumed locally in Andalusia.[7]
- Bergamot orange, C. aurantium subsp. bergamia is cultivated in Italy for the production of bergamot oil, a component of many brands of perfume and tea, especially Earl Grey tea.
- Chinotto, from the myrtle-leaved orange tree, C. aurantium var. myrtifolia, is used for the namesake Italian soda beverage. This is sometimes considered a separate species.
- Daidai, C. aurantium var. daidai, is used in Chinese medicine and Japanese New Year celebrations. The aromatic flowers are added to tea.[8]
- Wild Florida sour orange is found near small streams in generally secluded and wooded parts of Florida and the Bahamas. It was introduced to the area from Spain.[8]
Uses
In cooking
The unripe fruit, called narthangai, is commonly used in Southern Indian cuisine, especially in Tamil cuisine. It is pickled by cutting it into spirals and stuffing it with salt. The pickle is usually consumed with thayir sadam. The fresh fruit is also used frequently in pachadis.
The juice from the ripe fruit is also used as a marinade for meat in Nicaraguan, Cuban, Dominican and Haitian cooking.
The peel can be used in the production of bitters.
The Belgian Witbier (white beer) is a beer made from wheat spiced with the peel of the bitter orange.
The Finnish and Swedish use bitter orange peel in gingerbread (pepparkakor) and in mämmi. It is also used in the Nordic mulled wine glögg.
In Greece and Cyprus the nerántzi or kitrómilon respectively, is one of the most prized fruits used for spoon sweets, and the C. aurantium tree (nerantziá or kitromiliá) a popular ornamental tree.
In Iran the juice is used as fish marinade. The blossom is also used to flavor tea and jam.
In medicine
The extract of bitter orange (and bitter orange peel) has been used in dietary supplements as an aid to fat loss and as an appetite suppressant, although in traditional Chinese medicine it is always prescribed in concert with other support herbs, not alone. Bitter orange contains the tyramine metabolites N-methyltyramine, octopamine and synephrine,[9] substances similar to epinephrine, which acts on the α1 adrenergic receptor to constrict blood vessels and increase blood pressure and heart rate.[10][11]
The American Botanical Council has issed a press release on their review of Bitter Orange refuting these claims and stating that "No credible adverse events have been directly attributed to bitter orange, or its primary protoalkaloid, p-synephrine, in association with oral ingestion.”[12]
Following bans on the herbal stimulant ephedra in the U.S., Canada, and elsewhere, bitter orange has been substituted into "ephedra-free" herbal weight-loss products by dietary supplement manufacturers.[2] While bitter orange has not undergone formal safety testing, it can cause the same spectrum of adverse events as ephedra.[13] Case reports have linked bitter orange supplements to strokes,[14][15] angina,[9] and ischemic colitis.[16]
The National Center for Complementary and Alternative Medicine found that "there is currently little evidence that bitter orange is safer to use than ephedra."[4] There is no evidence that bitter orange is effective in promoting weight loss.[3]
Following the presentation of a healthy young man with a myocardial infarction (heart attack), a case study and subsequent literature review found that the makers of "nutritional supplements" who replaced ephedrine with its analogs p-synephrine and/or p-octopamine from "bitter orange" had in effect simply found a loophole in the FDA's April 2004 regulation banning ephedra in those supplements by substituting a similar substance the regulation did not address, while permitting them to label the products as "ephedra-free".[17]
Drug interactions
Bitter oranges may seriously interact with drugs such as statins in a similar way to grapefruit.[18]
Other uses
This orange is used as a rootstock in groves of sweet orange.[8]
The fruit and leaves make lather and can be used as soap.[8]
The hard white or light yellow wood is used in woodworking and made into baseball bats in Cuba.[8]
See also
References
- ^ "Citrus × aurantium L." Germplasm Resources Information Network. United States Department of Agriculture. 1999-12-17. Retrieved 2010-01-05.
- ^ a b Duenwald, Mary (2005-10-11). "Bitter Orange Under Scrutiny as New Ephedra". New York Times. Retrieved 2008-11-03.
{{cite news}}: Italic or bold markup not allowed in:|publisher=(help) - ^ a b Sharpe PA, Granner ML, Conway JM, Ainsworth BE, Dobre M (2006). "Availability of weight-loss supplements: Results of an audit of retail outlets in a southeastern city". Journal of the American Dietetic Association. 106 (12): 2045–51. doi:10.1016/j.jada.2006.09.014. PMID 17126636.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ a b "Bitter Orange". National Center for Complementary and Alternative Medicine. April 2008. Retrieved 2008-11-03.
- ^ "Dangerous Supplements: Twelve Supplements You Should Avoid" Consumer Reports Magazine, September 2010 http://www.consumerreports.org/cro/magazine-archive/2010/september/health/dangerous-supplements/supplements-to-avoid/index.htm
- ^ Campaña de recogida de la naranja amarga. sevilla.org.
- ^ Apenas se aprovechará la naranja que se recoja en la capital este año. 20minutos.es.
- ^ a b c d e C. aurantium. Purdue Horticulture.
- ^ a b Gange CA, Madias C, Felix-Getzik EM, Weintraub AR, Estes NA (2006). "Variant angina associated with bitter orange in a dietary supplement". Mayo Clinic Proceedings. 81 (4): 545–8. doi:10.4065/81.4.545. PMID 16610576.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Bui LT, Nguyen DT, Ambrose PJ (2006). "Blood pressure and heart rate effects following a single dose of bitter orange". The Annals of Pharmacotherapy. 40 (1): 53–7. doi:10.1345/aph.1G488. PMID 16317106.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Hess AM, Sullivan DL (2005). "Potential for toxicity with use of bitter orange extract and guarana for weight loss". The Annals of pharmacotherapy. 39 (3): 574–5. doi:10.1345/aph.1E249. PMID 15657116.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ http://cms.herbalgram.org/press/2011/BitterOrangeSafety.html?t=1300206712
- ^ Jordan S, Murty M, Pilon K (2004). "Products containing bitter orange or synephrine: suspected cardiovascular adverse reactions". Canadian Medical Association Journal. 171 (8): 993–4. PMID 15497209.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) [dead link] - ^ Bouchard NC, Howland MA, Greller HA, Hoffman RS, Nelson LS (2005). "Ischemic stroke associated with use of an ephedra-free dietary supplement containing synephrine". Mayo Clinic Proceedings. 80 (4): 541–5. doi:10.4065/80.4.541. PMID 15819293.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Holmes RO, Tavee J (2008). "Vasospasm and stroke attributable to ephedra-free xenadrine: case report". Military Medicine. 173 (7): 708–10. PMID 18700609.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ Sultan S, Spector J, Mitchell RM (2006). "Ischemic colitis associated with use of a bitter orange-containing dietary weight-loss supplement". Mayo Clinic Proceedings. 81 (12): 1630–1. doi:10.4065/81.12.1630. PMID 17165643.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Thomas JE, Munir JA, McIntyre PZ, Ferguson MA (2009). "STEMI in a 24-year-old man after use of a synephrine-containing dietary supplement : a case report and review of the literature". Tex Heart Inst J. 36 (6): 586–90. PMC 2801940. PMID 20069086.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Mayo clinic: article on interference between grapefruit and medication
External links
- Bitter Orange: Information from the National Center for Complementary and Alternative Medicine
- Bitter Orange List of Chemicals (Dr. Duke's Databases)
- Bitter Orange Under Scrutiny as New Ephedra, from the New York Times
- Citrus Aurantium listed in ingredients info (Beverly Hills Nutraceuticals)
