List of benzodiazepines

The below tables contain a sample list of benzodiazepines and benzodiazepine analogs that are commonly prescribed, with their basic pharmacological characteristics such as half-life and equivalent doses to other benzodiazepines also listed, along with their trade names and primary uses. The elimination half-life is how long it takes for half of the drug to be eliminated by the body. "Time to peak" refers to when maximum levels of the drug in the blood occur after a given dose. Benzodiazepines generally share the same pharmacological properties, such as anxiolytic, sedative, hypnotic, skeletal muscle relaxant, amnesic and anticonvulsant (hypertension in combination with other antihypertensive medications). Variation in potency of certain effects may exist amongst individual benzodiazepines. Some benzodiazepines produce active metabolites. Active metabolites are produced when a person's body metabolizes the drug into compounds that share a similar pharmacological profile to the parent compound and thus are relevant when calculating how long the pharmacological effects of a drug will last. Long-acting benzodiazepines with long-acting active metabolites such as diazepam and chlordiazepoxide are often prescribed for benzodiazepine or alcohol withdrawal as well as for anxiety if constant dose levels are required throughout the day. Shorter-acting benzodiazepines are often preferred for insomnia due to their lesser hangover effect.

It is fairly important to note that elimination half-life of diazepam and chlordiazepoxide as well as other long half-life benzodiazepines is twice as long in the elderly compared to younger individuals. Individuals with an impaired liver also metabolize benzodiazepines more slowly. Many doctors make the mistake of not adjusting benzodiazepine dosage according to age in elderly patients. Thus, the approximate equivalent of doses below may need to be adjusted accordingly in individuals on short acting benzodiazepines who metabolize long-acting benzodiazepines more slowly and vice versa. The changes are most notable with long acting benzodiazepines as these are prone to significant accumulation in such individuals. For example, the equivalent dose of diazepam in an elderly individual on lorazepam may be half of what would be expected in a younger individual. Equivalencies between individual benzodiazepines can differ by 400 fold on a mg per mg basis; awareness of this fact is necessary for the safe and effective use of benzodiazepines.

Dose equivalency table

Data in the table below is taken from the Ashton "Benzodiazepine Equivalency Table". The equivalences should be considered rough guidelines, as individual patient responses may vary widely.

Drug Name	Common Brand Names*	Approval Year (FDA)	Time to Peak (Onset of action in hours)	Elimination Half-Life (h)† [active metabolite] (Average hours and days)	Therapeutic use	Approximate Equivalent Dose‡
Alprazolam Middle power	Helex, Xanax, Xanor, Onax, Alprox, Restyl, Tafil	1981	1-2	9–20 hours (14.5h=0.6d)	anxiolytic, antidepressant	1 mg
Bentazepam Middle power	Thiadipona		1-3	2-4 hours (3h=0.12d)	anxiolytic	25 mg
Bretazenil High power	N/A		?	2.5 hours (=0.10d)	anxiolytic, anticonvulsant	0.5 mg
Bromazepam High power	Lectopam, Lexaurin, Lexotanil, Lexotan, Bromam		1-3	10–20 hours (15h=0.62d)	anxiolytic, hypnotic	5–6 mg
Brotizolam Very high power	Lendormin, Dormex, Sintonal, Noctilan		0.5-2	4–5 hours (4.5h=0.19d)	hypnotic	0.25 mg
Camazepam Middle power	Albego, Limpidon, Paxor		0.5-2	6-29 hours (17.5h=0.73d)	anxiolytic	10 mg
Chlordiazepoxide Very low power	Librium, Risolid, Elenium	1960	1.5-4	5–30 hours [36–200 hours] (17,5h=0,73d [118h=4.92d])	anxiolytic	25 mg
Cinolazepam High power	Gerodorm		0.5-2	9 hours (=0.37d)	sedative	40 mg
Clobazam Very low power	Onfi, Frisium, Urbanol	2011	1-3 hours	8–60 hours (34h=1.41d)	anxiolytic, anticonvulsant	20 mg
Clonazepam Very high power	Rivatril, Rivotril, Klonopin, Iktorivil, Paxam	1975	1-4	18–50 hours (34h= 1.41d)	anxiolytic, anticonvulsant	0.5 mg
Clorazepate High power	Tranxene, Tranxilium	1972	Variable	36–100 hours (68h=2.83d)	anxiolytic, anticonvulsant	15 mg
Clotiazepam Middle power	Veratran, Clozan, Rize		1-3	6–18 hours (12h=0.5d)	anxiolytic	5–10 mg
Cloxazolam High power	Sepazon, Olcadil		2-5 (?)	18–50 hours (34h= 1.41d)	anxiolytic, anticonvulsant	1 m
Delorazepam Very high power	Dadumir		1-2	60–140 hours (100h=4.17d)	anxiolytic	1 mg
Deschloroetizolam High power	Thialprazolam		1-2	10–40 hours (25h=1.04d)	anxiolytic, antidepressant	about 2 mg
Diazepam High power	Antenex, Apaurin, Apzepam, Apozepam, Hexalid, Pax, Stesolid, Stedon, Valium, Vival, Valaxona	1963	1-1.5	20–100 hours [36–200] (60h=2.5d [118h=4.92d]	anxiolytic, anticonvulsant, muscle relaxant	10 mg
Diclazepam High power		N/A	1.5-4 (4-6)	10–200 hours [42–220 hours (105h=4.37d [131h=5.46d])	anxiolytic, anticonvulsant, hypnotic muscle relaxant, sedative, skeletal muscle relaxant	1-1.5 mg
Estazolam Middle power	ProSom, Nuctalon	1999	1-5	10–24 hours (17h=0.71d)	anxiolytic, antidepressant	2 mg
Ethyl carfluzepate High power		N/A	1-5	11–24 hours (17.5h=0.73d)	hypnotic	2 mg
Etizolam Very high power	Etilaam, Etizest, Pasaden, Depas		1-2	6 hours (=0.25d)	anxiolytic, hypnotic,Amnesic	1 mg
Ethyl loflazepate Very low power	Victan, Meilax, Ronlax		2.5-3	50–100 hours (75h= 3.12d)	anxiolytic	2 mg
Flubromazepam High power		N/A	1.5-4 (4-8)	100–220 hours (160h=6.67d)	anxiolytic, anticonvulsant, hypnotic muscle relaxant, sedative	4-6 mg
Flunitrazepam Very high power	Rohypnol, Hipnosedon, Vulbegal, Fluscand, Flunipam, Ronal, Rohydorm,	1983	0.5-3	18–26 hours [36–200 hours] (22h=0.92d [118h=4.92d])	hypnotic	1 mg
Flurazepam Middle power	Dalmadorm, Dalmane	1973	1-1.5	40–250 hours (145h=6.04d)	hypnotic	15–30 mg
Flutoprazepam High power	Restas		0.5-9	60–90 hours (75h=3.12d)	hypnotic, anticonvulsant	2–3 mg
Halazepam Low power	Paxipam		1-3	30–100 hours (65h=2.71d)	anxiolytic	20–40 mg
Ketazolam Middle power	Anxon	N/A	2.5-3	30–100 hours [36–200] (65h=2.71d [118h=4.92d])	anxiolytic	15–30 mg
Loprazolam High power	Dormonoct		0.5-4	6–12 hours (9h=0.37d)	hypnotic	2 mg
Lorazepam Very high power	Ativan, Lorenin, Lorsilan, Temesta, Tavor, Lorabenz	1977	2-4	10–20 hours (15h=0.62d)	anxiolytic, amnesic, anticonvulsant, hypnotic	1-2 mg
Lormetazepam Middle power	Loramet, Noctamid, Pronoctan		0.5-2	10–12 hours (11h=0.46d)	hypnotic	1.5 mg
Medazepam Middle power	Nobrium, Ansilan, Mezapam, Rudotel, Raporan		1-1.5	36–200 hours (118h=4.92j)	anxiolytic	10 mg
Midazolam Very high power	Dormicum, Versed, Hypnovel, Dormonid	1985	0.5-1	1.8–6 hours (3.9h=0.16d)	hypnotic, anticonvulsant	7.5 mg
Nimetazepam High power	Erimin		0.5-3	14–30 hours (27h=1.12d)	hypnotic	5 mg
Nitrazepam Middle power	Mogadon, Alodorm, Pacisyn, Dumolid, Nitrazadon	1965	0.5-7	15–38 hours (26.5h=1.10d)	hypnotic, anticonvulsant	10 mg
Nordiazepam Low power	Madar, Stilny		?	50–120 hours (85h=3.54d)	anxiolytic	15 mg
Oxazepam Low power	Seresta, Serax, Serenid, Serepax, Sobril, Oxabenz, Oxapax, Opamox	1965	3-4	4–15 hours (9.5h=0.4d)	anxiolytic	25 mg
Phenazepam Very high power	Phenazepam		1.5-4	60 hours (=2.5d)	anxiolytic, anticonvulsant	1 mg
Pinazepam Middle power	Domar		?	40–100 hours (70h=2,92d)	anxiolytic	20 mg
Prazepam Low power	Lysanxia, Centrax	N/A	2-6	36–200 hours (118h=4.92d)	anxiolytic	15 mg
Premazepam Middle power		N/A	2-6	10–13 hours (11.5h=0.48d)	anxiolytic	15 mg
Pyrazolam High power	Pyrazolam, Bromazolam		1-1.5	16-18 hours (17h=0.71d)	anxiolytic	1 mg
Quazepam High power	Doral	1985	1-5	39–120 hours (79.5h=3.31d)	hypnotic	20 mg
Temazepam High power	Restoril, Normison, Euhypnos, Temaze, Tenox	1969	0.5-3	8–22 hours (15h=0.62d)	hypnotic	20 mg
Tetrazepam Very low power	Myolastan		1-3	3–26 hours (14.5h=0.60d)	Skeletal muscle relaxant	100 mg
Triazolam Very high power	Halcion, Rilamir	1982	0.5-2	2 hours (=0.08d)	hypnotic	0.25 mg (0.5 mg with oral bioavailability)

Atypical benzodiazepine receptor ligands

Drug Name	Common Brand Names*	Approval Date (FDA)	Elimination Half-Life (h)† [active metabolite]	Primary Effects	Approximate Equivalent Dose‡
DMCM	?		?	anxiogenic, convulsant	Non-applicable
Flumazenil**	Anexate, Lanexat, Mazicon, Romazicon		1 hour	antidote	Typical dose 0.2 - 0.6 mgð
Eszopiclone§	Lunesta	2004	6 hours	hypnotic	3 mg
Zaleplon§	Sonata, Starnoc	1999	1 hour	hypnotic	20 mg
Zolpidem§	Ambien, Nytamel, Sanval, Stilnoct, Stilnox, Sublinox (Canada), Xolnox, Zoldem, Zolnod	1992	2.6 hours	hypnotic	20 mg
Zopiclone§	Imovane, Rhovane, Ximovan; Zileze; Zimoclone; Zimovane; Zopitan; Zorclone,		4–6 hours	hypnotic	15 mg

* Not all trade names are listed. Click on drug name to see a more comprehensive list.
^‡ Equivalent doses are based on clinical experience but may vary between individuals.

** Flumazenil is an imidazobenzodiazepine derivative, and in layman's terms, it is a benzodiazepine overdose antidote that is given intravenously in Intensive Care Units (ICUs) to reverse the effects of benzodiazepine overdoses, as well for overdoses of the non-benzodiazepine "Z-drugs" such as Ambien and Lunesta. Flumazenil is contraindicated for benzodiazepine-tolerant patients in overdose cases. In such cases, the benefits are far outweighed by the risks, which include potential and severe seizures. The method by which Flumazenil acts to prevent non-benzodiazepine tolerant overdose from causing potential harm is via preventing the benzodiazepines and Z-drugs from binding to the GABA_A receptors via competitive inhibition which the Flumazenil creates. Clinical observation notating the patient's oxygen levels, respiratory, heart and blood pressure rates are used, as they are much safer than the potential seizure effects from Flumazenil. Supportive care to mediate any problems resulting from abnormal rates of the pulmonary, respiratory, and cardiovascular systems is typically the only treatment that is required in benzodiazepine-only overdoses. In most cases, activated charcoal/carbon is often used to prevent benzodiazepines from being absorbed by the gastrointestinal tract, and the use of stomach-pumping/gastric lavage is no longer commonly used nor suggested by some toxicologists. Even in cases where other central nervous system (CSN) depressants (such as in combined benzodiazepine and tricyclic antidepressant/TCA overdoses) are detected and/or suspected, endotrachial intubation for the airway path and supportive oxygen are typically implemented and are much safer than Flumazenil.

Controversy

The Ashton Manual claims the potency of both alprazolam and clonazepam to be 0.5 mg equivalent to 10 mg of diazepam, whereas most sources give an 1 mg equivalent to 10 mg of diazepam.

Another chart with different ratios can be seen in the pdf document released by the Australian Department of Health. It notes that 10 mg of diazepam is equivalent to 1 mg of alprazolam and 0.5 - 1 mg of clonazepam.

The UK's House of Commons began APPGITA/The All Party Parliamentary Group on Involuntary Tranquilliser Addiction. Since 2002, APPGITA has tried to politically mandate prescribing guidelines for benzodiazepines. APPGITA has attempted to get a two to four week limit mandate for prescribing benzodiazepines to replace the two to four week benzodiazepine prescribing guidelines, which are merely recommended.

See also

• Benzodiazepine
• Benzodiazepine dependence
• Benzodiazepine withdrawal syndrome

Further reading

• Gitlow, Stuart (1 October 2006). Substance Use Disorders: A Practical Guide (2nd ed.). USA: Lippincott Williams and Wilkins. p. 110. ISBN 978-0-7817-6998-3.
• Galanter, Marc; Kleber, Herbert D. (1 July 2008). The American Psychiatric Publishing Textbook of Substance Abuse Treatment (4th ed.). United States of America: American Psychiatric Publishing Inc. p. 216. ISBN 978-1-58562-276-4. {{cite book}}: Cite has empty unknown parameter: |chapterurl= (help)