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Alternative medicine
Medicinal herbs in a traditional Spanish market
General information
Fringe medicine and science
Controversies
Classifications
Traditional medicine
Alternative diagnoses
Alternative medicine
MeSHD000529

Alternative medicine is any practice that is put forward as having the healing effects of medicine, but is not based on evidence gathered with the scientific method.[1] Alternative medicine is usually based on tradition, superstition,[2] belief in supernatural energies, pseudoscience, errors in reasoning, propaganda, or fraud.[3][4][5][6] Alternative therapies lack scientific validation, and their effectiveness is either unproved or disproved.[4][7][8] The treatments are those that are not part of the conventional, science-based healthcare system.[9][10][11][12][13]

Alternative medicine is sometimes grouped with complementary medicine which, in general, refers to the same interventions when used in conjunction with mainstream techniques,[14][15][16] under the umbrella term complementary and alternative medicine, or CAM.[17][18] Integrative medicine (or integrative health) is the combination of the practices and methods of alternative medicine with evidence based medicine.[19] Critics maintain that the terms “complementary” and “alternative medicine” are deceptive euphemisms meant to give an impression of medical authority.[20][21][22]

Alternative medicine practices and beliefs are diverse in their foundations and methodologies. Methods may incorporate or base themselves on traditional medicine, folk knowledge, spiritual beliefs, ignorance or misunderstanding of scientific principles, errors in reasoning, or newly conceived approaches claiming to heal.[23][5][4] Prayer to heal is the most common alternative medicine in many western countries, and faith healing is a part of many religions. Some believe that meditation affects health. Yoga as a healing practice involves stretching, exercise and meditation related to the Hindu religion, and makes claims to healing in the spiritual realm. Traditional Chinese medicine and the Ayurvedic medicine of India are complex systems developed over thousands of years, both based on regional supernatural belief systems and traditional use of herbs and other substances. Acupuncture is a part of Traditional Chinese medicine in which needles are inserted in the body to alter supernatural energy flow believed to propel the blood and inflence health. Chiropractic manipulation of the spine was developed in the United States, and involves manipulating the spine to influence supernatural energies believed to case disease. Homeopathy was developed in Europe before the science of chemistry existed, which proved it to be false. Magnets and light are used in therapies based on a misunderstanding of electricity and magnetism . Dietary supplements that are unproven by science are considered alternative medicines. African, Caribbean, Pacific Island, Native American, and other regional cultures have traditional medical systems as diverse as their diversity of cultures.[24]

Many of the claims regarding the efficacy of alternative medicines are controversial. Research on alternative medicine is frequently of low quality and methodologically flawed.[25] The safety of alternative medicine is also controversial. Some alternative treatments have been associated with unexpected side effects, which can be fatal. Alternative treatments are used in place of conventional science based medicines, but even with the very safest alternative medicines, delays and absences of conventional science based medicine has resulted in deaths where they are ineffective.[26][27] Some voluntary health agencies focused upon health fraud, misinformation, and quackery as public health problems, have been highly critical of alternative medicine.[28] The phenomena of how alternative medicine can be on the rise “in countries where Western science and scientific method generally are accepted as the major foundations for healthcare, and ‘evidence-based’ practice is the dominant paradigm" has been described as an "enigma" in the Medical Journal of Australia.[29]

Examples and classes of alternative medicines

Further information: List of branches of alternative medicine
A Botanica of traditional Hispanic medicines may look like a pharmacy of science based medicines. The difference is not in their appearance, but in the basis for belief that the medicines have a healing effect.

Alternative medicine practices are diverse in their foundations and methodologies.[9] Methods may incorporate or base themselves on traditional medicinal practices of a particular culture, folk knowledge, supersition,[2] spiritual, belief in supernatural energies (antiscience), pseudoscience, errors in reasoning, propaganda, fraud, new or different concepts of health and disease, and any bases other than being proven by scientific methods.[3][4][5][30] Alternative therapies lack scientific validation, and their effectiveness is either unproved or disproved.[4][7][8] Different cultures may have their own unique traditional or belief based practices developed recently or over thousands of years, and specific practices or entire systems of practices. Alternative medicine practices may be classified by their cultural origins or by the types of beliefs upon which they are based.[3][4][5][9]

Complete systems

Complete medical systems can be based on traditional ethinic practices, or an underlying belief system.[9]

Traditional ethnic systems

Indian Ayurvedic medicine includes a belief that the spiritual balance of Hinduism and Buddhism influences disease.
In Japanese Reiki, it is believed that supernatural energies flow from the palms of the healer into the patient near Chakras, influencing disease.

Whole medical systems may be based on traditional practices, such as Traditional Chinese medicine, Ayurveda in India, or practices of other cultures around the world.[9] In both Traditional Chinese Medicine and Ayurveda, the thousands of years of traditional use in the respective cultures may be cited as part of the basis of belief, or of claims of efficacy and validity.[citation needed]

Ayurvedic medicine

Ayurvedic medicine is a traditional medicine of India, and includes a belief that use of traditional herbs and having the spiritual balance of the religions of Hinduism and Buddhism, including by suppressing natural urges of food intake, sleep, and sexual intercourse, can be used to heal.[31]

Traditional Chinese Medicine

Traditional Chinese Medicine is based on belief in a supernatural energy called qi, considerations of Chinese Astrology as in acupuncture, traditional use of herbs and other substances found in China, a belief that a map of the body is contained on the tongue which reflects changes in the body, and an incorrect model of the anatomy and physiology of internal organs.[32][33][4][34][35]

The Chinese Communist Party Chairman Mao Zedong, in response to the lack of modern medical practitioners, revived acupuntcute and its theory was rewritten to adhere to the political, economic and logistic necessities of providing for the medical needs of China's population.[36] In the 1950s the "history" and theory of Traditional Chinese Medicine was rewritten as communist propoganda, at Mao's insistence, to correct the supposed "bourgeois thought of Western doctors of medicine" (p. 109).[37] Acupuncture gained attention in the United States when President Richard Nixon visited China in 1972, and the delegation was shown a patient undergoing major surgery while fully awake, ostensibly receiving acupuncture rather than anesthesia. Later it was found that the patients selected for the surgery had both a high pain tolerance and received heavy indoctrination before the operation; these demonstration cases were also frequently receiving morphine surreptitiously through an intravenous drip that observers were told contained only fluids and nutrients.[38]

Systems based on beliefs

Whole medical systems can be based on a common belief systems that underly the system of practices and methods, such as in Naturopathy or Homeopathy.[9]

Homeopathy is a system developed in a belief that a substance that causes the symptoms of a disease in healthy people will cure similar symptoms in sick people.[39] It was developed before knowledge of the existence of atoms and molecules, and of basic chemistry, which showed that the repeated dilutions of the substance in homeopathy produced only water, and so homeopathy was false.[40][41][42][43] Within the medical community homeopathy is now considered to be quackery.[44]

Naturopathic medicine is based on a belief that the body heals itself using a supernatural vital energy that guides bodily processes,[45] a view in conflict with the paradigm of evidence-based medicine.[46] Many naturopaths have opposed vaccination,[47] and "scientific evidence does not support claims that naturopathic medicine can cure cancer or any other disease".[48]

Supernatural energies and misunderstanding of energy in physics

Bases of belief may include belief in existence of supernatural energies undetected by the science of physics, as in biofields, or in belief in properties of the energies of physics that are inconsistent with the laws of physics, as in energy medicine.[9]

Biofields

In Chinese acupuncture it is believed that insertion of needles affects the flow of a supernatural energy influencing disease.
Chiropractic was developed in the US in the belief that manipulation of the spine affects a supernatural vital energy that influences health and disease.

Biofield therapies are intended to influence energy fields that, it is purported, surround and penetrate the body.[9] No empirical evidence has been found to support the existence of the putative energy fields on which these therapies are predicated.[49]

Acupuncture is a component of Traditional Chinese Medicine. In acupuncture, it is believed that a supernatural energy called qi flows through the universe and through the body, and helps propel the blood, blockage of which leads to disease.[32] It is believed that insertion of needles at various parts of the body determined by astrological calculations can restore balance to the blocked flows, and thereby cure disease.[32]

Chiropractic was developed in the belief that manipulating the spine affects the flow of a supernatural vital energy and thereby affects health and disease.

In the western version of Japanese Reiki, the palms are placed on the patient near Chakras, believed to be centers of supernatural energies, in a belief that the supernatural energies can transfered from the palms of the practitioner, to heal the patient.

Energy medicines

Bioelectromagnetic-based therapies use verifiable electromagnetic fields, such as pulsed fields, alternating-current, or direct-current fields in an unconventional manner.[9] Magnetic healing does not claim existence of supernatural entergies, but asserts that magnets can be used to defy the laws of physics to influence health and disease.

Holistic health and mind body medicine

Mind-body medicine takes a holistic approach to health that explores the interconnection between the mind, body, and spirit. It works under the premise that the mind can affect "bodily functions and symptoms".[9] Mind body medicines includes healing claims made in yoga, meditation, deep-breathing exercises, guided imagery, hypnotherapy, progressive relaxation, qi gong, and tai chi.[9]

Yoga, a method of traditional stretches, excercises, and meditations in Hinduism, may also be classified as an energy medicine insofar as its healing effects are believed by to be due to a healing "life energy" that is absorbed into the body through the breath, and is thereby believed to treat a wide variety of illnesses and complaints.[50]

Herbal remedies and other substances used

Substance based practices use substances found in nature such as herbs, foods, non-vitamin supplments and megavitmins, and minerals, and includes traditional herbal remedies with herbs specific to regions in which the cultural practices arose.[9] "Herbal" remedies in this case, may include use of nonherbal toxic chemicals from a nonbiological sources, such as use of the poison lead in Traditional Chinese Medicine.[51] Nonvitamin supplements include fish oil, Omega-3 fatty acid, glucosamine, echinacea, flaxseed oil or pills, and ginseng, when used under a claim to have healing effects.[51]

Body manipulation

Manipulative and body-based practices feature manipulation or movement of body parts, such as is done in chiropractic manipulation.

Religion, faith healing, and prayer

Christian priest Faith healer laying hands on sick girl in belief in divine healing.

Religion based healing practices, such as use of prayer and the laying of hands in Christian faith healing, rely on belief in divine intervention for healing.

In the United States, the 1974 Child Abuse Prevention and Treatment Act (CAPTA) required states to grant religious exemptions to child neglect and abuse laws in order to receive federal money.[52] Thirty-one states have child-abuse religious exemptions.[53]

Exploitation of ignorance and flawed reasoning

Some alternative medicine practices may be based on pseudoscience, ignorance, or flawed reasoning.[54] This can lead to fraud.[4] Homeopathy was developed prior to knowledge of the theory of molecules and basic chemistry, which proved that its "remedies" contained nothing more than distilled water.[40][41][42][43] Practitioners of electricity and magnetism based healing methods may deliberately exploit a patient's ignorance of physics in order to defraud them.[3]

Criticism

Scientists and others have criticized complementary and alternative medicine (CAM) on a number of grounds. The name "alternative medicine" has been criticized as being an invention to delibertely mislead sick people into thinking there is an effecgive alternative to science based medicine. The science community criticizes CAM on the grounds that it is ineffective, is based on ignorance of basic science, is based on incorrect reasoning, and refuses to admit to when it is disproved. It has been criticized as being unethical and used for fraud. There is criticism that it takes research funds from testing more scientifically plausible methods. Integrative medicine has been criticized in that its practitioners, trained in science based medicine, deliberately mislead patients by pretending placebos are not. "Quackademic medicine" is a pejorative term used for “integrative medicine”, which is considered to be an infiltration of quackery into academic science-based medicine.[22]

Misleading use of terminology

Proponents of alternative medicine often use terminology which is loose or ambiguous to create the appearance that a choice between "alternative" effective treatments exists when it does not, that there is effectiveness or scientific validity when it does not exist, to suggest that a dichotomy exists when it does not, or to suggest that consistency with science exists when it may not. The term "alternative" is to suggest that a patient has a choice between effective treatments when there is not. The use of the word "conventional" or "mainstream" is to suggest that the difference between alternative medicine and science based medicine is the prevalence of use, rather than lack of a scientific basis of alternative medicine as compared to "conventional" or "mainstream" science based medicine. The use of the term "complementary" is to suggest that purported supernatural entergies of alternative medicine can add to or complement science based medicine. The use of "Western medicine" and "Eastern medicine" is to suggest that the difference is not between evidence based medicine and treatments which don't work, but a cultural difference between the Asiatic east and the European west. The use of the term "integrative" is to suggest that supernatural beliefs can be consistently integrated with science and the result has scientific validity. [55]

"Alternative medicine" refers to any practice that is put forward as having the healing effects of medicine, but is not based on evidence gathered with the scientific method,[3] when used independently or in place of medicine based on science.[10][56][57][58] "Complementary medicine" refers to use of alternative medicine alongside conventional science based medicine, in the belief that it increases the effectiveness.[10][56][57] "CAM" is an abbreviation for "complementary and alternative medicine". "Integrative medicine" ("integrated medicine") is used either to refer to a belief that medicine based on science can be "integrated" with practices that are not, or that a combination of alternative medical treatments with conventional science based treatments that have some scientific proof of efficacy, in which case it is identical with CAM.[19] “Whole medical systems” either refers to a spiritual belief, that “spiritual wholeness” is the root of physiological and physical well-being,[59] Ayurveda, Chinese medicine, Homeopathy and Naturopathy are cited as examples[9] or to differentiate widely comprehensive systems from either specific components of the system or from practices that claim to heal only a limited kind of specific medical conditions.

There is a debate among medical researchers over whether any therapy may be properly classified as 'alternative medicine'. Some claim that there is only medicine that has been adequately tested and that which has not.[60] "There really is no such thing as alternative medicine--only medicine that has been proved to work and medicine that has not." - Arnold Relman, editor in chief emeritus of The New England Journal of Medicine.[61][full citation needed] Speaking of government funding studies of integrating alternative medicine techniques into the mainstream, Steven Novella, a neurologist at Yale School of Medicine wrote that it "is used to lend an appearance of legitimacy to treatments that are not legitimate." Marcia Angell, former executive editor of The New England Journal of Medicine says, "It's a new name for snake oil."[62] They feel that healthcare practices should be classified based solely on scientific evidence. If a treatment has been rigorously tested and found safe and effective, science based medicine will adopt it regardless of whether it was considered "alternative" to begin with.[60] It is thus possible for a method to change categories (proven vs. unproven), based on increased knowledge of its effectiveness or lack thereof. Prominent supporters of this position include George D. Lundberg, former editor of the Journal of the American Medical Association (JAMA).[63]

Criticism on scientific grounds

An editorial in the Economist characterized alternative medicine as mostly "quackery" and described the vast majority as offering nothing more than the placebo effect (the effect of taking a sugar pill and thinking it is medicine). It suggested that, "Virtually all alternative medicine is bunk; but the placebo effect is rather interesting."[64]

Stanford University medical professor Wallace Sampson, former chairperson of the National Council Against Health Fraud, advisor to the California Attorney General and numerous district attorneys on medical fraud, and editor of Scientific Review of Alternative Medicine, writes that CAM is the "propagation of the absurd". He argues that alternative and complementary have been substituted for quackery, dubious and implausible.[65]

Richard Dawkins, an evolutionary biologist, defines alternative medicine as a "set of practices that cannot be tested, refuse to be tested, or consistently fail tests."[66] He also states that "there is no alternative medicine. There is only medicine that works and medicine that doesn't work."[67] He says that if a technique is demonstrated effective in properly performed trials, it ceases to be alternative and simply becomes medicine.[68]

Based on incorrect reasoning

A letter by four Nobel Laureates and other prominent scientists deplored the lack of critical thinking in research on alternative medicine that was supprted by the National Institutes of Health (NIH).[69]

Based on ignorance of basic scientific facts

In 2009 a group of scientists made a proposal to shut down the National Center for Complementary and Alternative Medicine. They argued that the vast majority of studies were based on fundamental misunderstandings of physiology and disease, and have shown little or no effect.[70]

Ineffective and misleading statements on efficacy

The United States' National Science Foundation has defined alternative medicine as "all treatments that have not been proven effective using scientific methods."[3] Proponents of an evidence-base for medicine, such as the Cochrane Collaboration take a position that all treatments, whether "mainstream" or "alternative", ought to be held to the standards of the scientific method.[71] Stephen Barrett, founder and operator of Quackwatch, argues that practices labeled "alternative" should be reclassified as either genuine, experimental, or questionable. Here he defines genuine as being methods that have sound evidence for safety and effectiveness, experimental as being unproven but with a plausible rationale for effectiveness, and questionable as groundless without a scientifically plausible rationale.[72] Edzard Ernst, a professor of complementary medicine, characterizes the evidence for many alternative techniques as weak, nonexistent, or negative.[73] Ernst has concluded that 95% of the alternative treatments he and his team have studied, including acupuncture, herbal medicine, homeopathy, and reflexology, are, according to The Economist, "statistically indistinguishable from placebo treatments."[74]

Unfalsifiable

Wallace Sampson points out that CAM tolerates contradiction without thorough reason and experiment.[65] Steven Barrett points out that there is a policy at the NIH of never saying something doesn't work only that a different version or dose might give different results.[75]

Using plausibility of one practice to support implausible other practices

Steven Barrett also expressed concern that, just because some "alternatives" have merit, there is the impression that the rest deserve equal consideration and respect even though most are worthless, since they are all classified under the one heading of alternative medicine.[72] A group of prominent scientists argued before the federal government that plausibility of interventions such as diet, relaxation, yoga and botanical remedies, should not be used to support research on implausible interventions based on superstition and belief in the supernatural, and that the plausible methods can be studied just as well in other parts of NIH, where they should be made to compete on an equal footing with other research projects.[70]

Taking resources from real medical research, abuse of medical authority

The NCCAM budget has been criticized[62] because, despite the duration and intensity of studies to measure the efficacy of alternative medicine, there had been no effective CAM treatments supported by scientific evidence as of 2002 according to the QuackWatch website.[76] Despite this, the National Center for Complementary and Alternative Medicine budget has been on a sharp sustained rise to support complementary medicine. In fact, the whole CAM field has been called by critics the SCAM.[76]

There have been negative results in almost all studies conducted over ten years at a cost of $2.5 billion by the NCCAM.[77] R. Barker Bausell, a research methods expert and author of "Snake Oil Science" states that "it's become politically correct to investigate nonsense."[75] There are concerns that just having NIH support is being used to give unfounded "legitimacy to treatments that are not legitimate."[70]

Use of placebos in order to achieve a placebo effect in integrative medicine has been criticized as “diverting research time, money, and other resources from more fruitful lines of investigation in order to pursue a theory that has no basis in biology”.[22][78]

Ethics, dangerous misinformation, fraud

Speaking of ethics, in November 2011 Edzard Ernst stated that the "level of misinformation about alternative medicine has now reached the point where it has become dangerous and unethical. So far, alternative medicine has remained an ethics-free zone. It is time to change this."[79] Ernst requested that Prince Charles recall two guides to alternative medicine published by the Foundation for Integrated Health, on the grounds that "[t]hey both contain numerous misleading and inaccurate claims concerning the supposed benefits of alternative medicine" and that "[t]he nation cannot be served by promoting ineffective and sometimes dangerous alternative treatments."[80] In general, he believes that CAM can and should be subjected to scientific testing.[71][73][81] Ernst requested that Prince Charles recall two guides to alternative medicine published by the Foundation for Integrated Health, on the grounds that "[t]hey both contain numerous misleading and inaccurate claims concerning the supposed benefits of alternative medicine" and that "[t]he nation cannot be served by promoting ineffective and sometimes dangerous alternative treatments".[80] [71][73][81]

Marketing is part of the medical training required in chiropractic educaion, and propoganda methods in alternative medicine have been traced back to those used by Hitler and Goebels in thier promotion of pseudoscience in medicine.[4][82]

Integrative medicine practitioners intentionally mislead patients

Academic proponents of integrative medicine sometimes recommend misleading patients by using known placebo treatments in order to achieve a placebo effect.[83] However, a 2010 survey of family physicians found that 56% of respondents said they had used a placebo in clinical practice as well. Eighty-five percent of respondents believed placebos can have both psychological and physical benefits.[84][85]

Use and regulation

Prevalence of use

Studies show that prayer is a common "complementary" practice, in the belief it might increase the efficacy of science based medicine.

About 50% of people in developed countries use some kind of complementry and alternative medicine other than prayer for health.[86][87][88][89] About 40% of cancer patients use some form of CAM.[90] The use of alternative medicine in developed countries is increasing,[3][91][92] with a 50 percent increase in expenditures and a 25 percent increase in the use of alternative therapies between 1990 and 1997 in America.[93] Americans spend many billions on the therapies annually.[93] Most Americans used CAM to treat and/or prevent musculoskeletal conditions or other conditions associated with chronic or recurring pain.[87] In America, women were more likely than men to use CAM., with the biggest difference in use of mind-body therapies including prayer specifically for health reasons".[87] In 2008, more than 37% of American hospitals offered alternative therapies, up from 26.5 percent in 2005, and 25% in 2004.[94][95] More than 70% of the hospitals offering CAM were in urban areas.[95]

The phenomena of how alternative medicine can be on the rise “in countries where Western science and scientific method generally are accepted as the major foundations for healthcare, and ‘evidence-based’ practice is the dominant paradigm" has been described as an "enigma" in the Medical Journal of Australia.[29] Use of alternative therapies was found to be higher among those who had attended college and had higher incomes.[93] A survey of Americans found that 88 percent agreed that "there are some good ways of treating sickness that medical science does not recognize".[3] Use of magnets was the most common tool in energy medicine in America, and among users of it, 58 percent described it as at least “sort of scientific”, when it is not at all scientific.[3] In 2002, at least 60 percent of US medical schools have at least some class time spent teaching alternative therapies.[3] "Therapeutic touch," was taught at more than 100 colleges and universities in 75 countries before the practice was debunked by a nine-year-old child for a school science project. [3][96][3] In Austria and Germany complementary and alternative medicine is mainly in the hands of doctors with MDs,[17] and half or more of the American alternative practitioners are licensed MDs.[97] In Germany herbs are tightly regulated: half are prescribed by doctors and covered by health insurance.[98]

In developing nations, access to essential medicines is severely restricted by lack of resources and poverty. Traditional remedies, often closely resembling or forming the basis for alternative remedies, may comprise primary healthcare or be integrated into the healthcare system. In Africa, traditional medicine is used for 80% of primary healthcare, and in developing nations as a whole over one-third of the population lack access to essential medicines.[99]

A 1997 survey found that 13.7% of respondents in the United States had sought the services of both a medical doctor and an alternative medicine practitioner. The same survey found that 96% of respondents who sought the services of an alternative medicine practitioner also sought the services of a medical doctor in the past 12 months. Medical doctors are often unaware of their patient's use of alternative medical treatments as only 38.5% of the patients alternative therapies were discussed with their medical doctor.[91] A British telephone survey by the BBC of 1209 adults in 1998 shows that around 20% of adults in Britain had used alternative medicine in the past 12 months.[100]

Prevalence of use of specific therapies

The most common CAM therapies used in the US in 2002 were prayer (45.2%), herbalism (18.9%), breathing meditation (11.6%), meditation (7.6%), chiropractic medicine (7.5%), yoga (5.1%-6.1%), body work (5.0%), diet-based therapy (3.5%), progressive relaxation (3.0%), mega-vitamin therapy (2.8%) and Visualization (2.1%)[87][101]

In Brittain, the most often used altrnative therapies were Alexander technique, Aromatherapy, Bach and other flower remedies, Body work therapies including massage, Counselling stress therapies, hypnotherapy, Meditation, Reflexology, Shiatsu, Ayurvedic medicine, Nutritional medicine, and Yoga.[102]

"Complementary medicine treatments used for pain include: acupuncture, low-level laser therapy, meditation, aroma therapy, Chinese medicine, dance therapy, music therapy, massage, herbalism, therapeutic touch, yoga, osteopathy, chiropractic, naturopathy, and homeopathy."[103]

Palliative care

Complementary therapies are often used in palliative care or by practitioners attempting to manage chronic pain in patients. Complementary medicine is considered more acceptable in the interdisciplinary approach used in palliative care than in other areas of medicine. "From its early experiences of care for the dying, palliative care took for granted the necessity of placing patient values and lifestyle habits at the core of any design and delivery of quality care at the end of life. If the patient desired complementary therapies, and as long as such treatments provided additional support and did not endanger the patient, they were considered acceptable."[104] The non-pharmacologic interventions of complementary medicine can employ mind-body interventions designed to "reduce pain and concomitant mood disturbance and increase quality of life."[105]

Regulation

Further information: Regulation of alternative medicine

Some fields of alternative practice are regulated in a manner similar to that governing science-based medicine, and some have no regulation at all. Regulation and licensing of alternative medicine ranges widely from country to country, and state to state.

Efficacy

Alternative therapies lack scientific validation, and their effectiveness is either unproved or disproved.[3][4][7][8] Many of the claims regarding the efficacy of alternative medicines are controversial, since research on them is frequently of low quality and methodologically flawed.[25] Selective publication of results (misleading results from only publishing postive results, and not all results), marked differences in product quality and standardisation, and some companies making unsubstantiated claims, call into question the claims of efficacy of isolated examples where herbs may have some evidence of containing chemicals that may affect health.[106] The Scientific Review of Alternative Medicine points to confusions in the general population - a person may attribute symptomatic relief to an otherwise-ineffective therapy just because they are taking something (the placebo effec); the natural recovery from or the cyclical nature of an illness (the regression fallacy) gets misattributed to an alternative medicine being taken; a person not diagnosed with science based medicine may never originally have had a true illness diagnosed as an alternative disease category.[107]

Testing

In 2003, a project funded by the CDC identified 208 condition-treatment pairs, of which 58% had been studied by at least one randomized controlled trial (RCT), and 23% had been assessed with a meta-analysis.[108] According to a 2005 book by a US Institute of Medicine panel, the number of RCTs focused on CAM has risen dramatically. The book cites Vickers (1998), who found that many of the CAM-related RCTs are in the Cochrane register, but 19% of these trials were not in MEDLINE, and 84% were in conventional medical journals.[25]: 133 

As of 2005, the Cochrane Library had 145 CAM-related Cochrane systematic reviews and 340 non-Cochrane systematic reviews. An analysis of the conclusions of only the 145 Cochrane reviews was done by two readers. In 83% of the cases, the readers agreed. In the 17% in which they disagreed, a third reader agreed with one of the initial readers to set a rating. These studies found that, for CAM, 38.4% concluded positive effect or possibly positive (12.4%) effect, 4.8% concluded no effect, 0.69% concluded harmful effect, and 56.6% concluded insufficient evidence. An assessment of conventional treatments found that 41.3% concluded positive or possibly positive effect, 20% concluded no effect, 8.1% concluded net harmful effects, and 21.3% concluded insufficient evidence. However, the CAM review used the 2004 Cochrane database, while the conventional review used the 1998 Cochrane database.[25]: 135–136 

Lists of the Cochrane Reviews on alternative medicine including summaries of the results sorted by type of therapy (updated monthly) are made available at ViFABs (Knowledge and Research Center for Alternative Medicines) home page, see the lists here: http://www.vifab.dk/uk/cochrane+and+alternative+medicine

Most alternative medical treatments are not patentable, which may lead to less research funding from the private sector. In addition, in most countries, alternative treatments (in contrast to pharmaceuticals) can be marketed without any proof of efficacy—also a disincentive for manufacturers to fund scientific research.[109] Some have proposed adopting a prize system to reward medical research.[110] However, public funding for research exists. Increasing the funding for research on alternative medicine techniques is the purpose of the US National Center for Complementary and Alternative Medicine. NCCAM and its predecessor, the Office of Alternative Medicine, have spent more than $2.5 billion on such research since 1992; this research has largely not demonstrated the efficacy of alternative treatments.[75][111][112]

In the same way as for conventional therapies, drugs, and interventions, it can be difficult to test the efficacy of alternative medicine in clinical trials. In instances where an established, effective, treatment for a condition is already available, the Helsinki Declaration states that withholding such treatment is unethical in most circumstances. Use of standard-of-care treatment in addition to an alternative technique being tested may produce confounded or difficult-to-interpret results.[113]

Cancer researcher Andrew J. Vickers has stated:

Contrary to much popular and scientific writing, many alternative cancer treatments have been investigated in good-quality clinical trials, and they have been shown to be ineffective. In this article, clinical trial data on a number of alternative cancer cures including Livingston-Wheeler, Di Bella Multitherapy, antineoplastons, vitamin C, hydrazine sulfate, Laetrile, and psychotherapy are reviewed. The label "unproven" is inappropriate for such therapies; it is time to assert that many alternative cancer therapies have been "disproven."[114]

Safety

See also: List of herbs with known adverse effects

Adequacy of Regulation and CAM Safety

One of the commonly voiced concerns about complementary alternative medicine (CAM) is the manner in which is regulated. There have been significant developments in how CAMs should be assessed prior to re-sale in the United Kingdom and the European Union (EU) in the last 2 years. Despite this, it has been suggested that current regulatory bodies have been ineffective in preventing deception of patients as many companies have re-labelled their drugs to avoid the new laws.[115] There is no general consensus about how to balance consumer protection (from false claims, toxicity, and advertising) with freedom to choose remedies.

Advocates of CAM suggest that regulation of the industry will adversely affect patients looking for alternative ways to manage their symptoms, even if many of the benefits may represent the placebo affect.[116] Some contend that alternative medicines should not require any more regulation than over-the-counter medicines that can also be toxic in overdose (such as paracetamol).[117]

Interactions with conventional pharmaceuticals

Forms of alternative medicine that are biologically active can be dangerous even when used in conjunction with conventional medicine. Examples include immuno-augmentation therapy, shark cartilage, bioresonance therapy, oxygen and ozone therapies, insulin potentiation therapy. Some herbal remedies can cause dangerous interactions with chemotherapy drugs, radiation therapy, or anesthetics during surgery, among other problems.[118] An anecdotal example of these dangers was reported by Associate Professor Alastair MacLennan of Adelaide University, Australia regarding a patient who almost bled to death on the operating table after neglecting to mention that she had been taking "natural" potions to "build up her strength" before the operation, including a powerful anticoagulant that nearly caused her death.[119]

To ABC Online, MacLennan also gives another possible mechanism:

And lastly [sic] there's the cynicism and disappointment and depression that some patients get from going on from one alternative medicine to the next, and they find after three months the placebo effect wears off, and they're disappointed and they move on to the next one, and they're disappointed and disillusioned, and that can create depression and make the eventual treatment of the patient with anything effective difficult, because you may not get compliance, because they've seen the failure so often in the past.|[120]

Potential side-effects

Conventional treatments are subjected to testing for undesired side-effects, whereas alternative treatments, in general, are not subjected to such testing at all. Any treatment – whether conventional or alternative – that has a biological or psychological effect on a patient may also have potential to possess dangerous biological or psychological side-effects. Attempts to refute this fact with regard to alternative treatments sometimes use the appeal to nature fallacy, i.e., "that which is natural cannot be harmful".

An exception to the normal thinking regarding side-effects is Homeopathy. Since 1938, the U.S. Food and Drug Administration (FDA) has regulated homeopathic products in "several significantly different ways from other drugs."[121] Homeopathic preparations, termed "remedies," are extremely dilute, often far beyond the point where a single molecule of the original active (and possibly toxic) ingredient is likely to remain. They are, thus, considered safe on that count, but "their products are exempt from good manufacturing practice requirements related to expiration dating and from finished product testing for identity and strength," and their alcohol concentration may be much higher than allowed in conventional drugs.[121]

Treatment delay

Those having experienced or perceived success with one alternative therapy for a minor ailment may be convinced of its efficacy and persuaded to extrapolate that success to some other alternative therapy for a more serious, possibly life-threatening illness.[122] For this reason, critics argue that therapies that rely on the placebo effect to define success are very dangerous. According to mental health journalist Scott Lilienfeld in 2002, "unvalidated or scientifically unsupported mental health practices can lead individuals to forgo effective treatments" and refers to this as "opportunity cost". Individuals who spend large amounts of time and money on ineffective treatments may be left with precious little of either, and may forfeit the opportunity to obtain treatments that could be more helpful. In short, even innocuous treatments can indirectly produce negative outcomes.[26]

Between 2001 and 2003, four children died in Australia because their parents chose ineffective naturopathic, homeopathic, or other alternative medicines and diets rather than conventional therapies.[27] In all, they found 17 instances in which children were significantly harmed by a failure to use conventional medicine.

Unconventional cancer "cures"

Perhaps because many forms of cancer are difficult or impossible to cure, there have always been many therapies offered outside of conventional cancer treatment centers and based on theories not found in biomedicine. These alternative cancer cures have often been described as "unproven," suggesting that appropriate clinical trials have not been conducted and that the therapeutic value of the treatment is unknown. However, many alternative cancer treatments have been investigated in good-quality clinical trials, and they have been shown to be ineffective. [123]

Research funding

Although the Dutch government funded CAM research between 1986 and 2003, it formally ended funding in 2006.[124]

History

Fueled by a nationwide survey published in 1993 by David Eisenberg, which revealed that in 1990 approximately 60 million Americans had used one or more complementary or alternative therapies to address health issues.[125] A study published in the November 11, 1998 issue of the Journal of the American Medical Association reported that 42% of Americans had used complementary and alternative therapies, up from 34% in 1990.[126] However, despite the growth in patient demand for complementary medicine, most of the early alternative/complementary medical centers failed.[127]

Appeal

A study published in 1998[89] indicates that a majority of alternative medicine use was in conjunction with standard medical treatments. Approximately 4.4 percent of those studied used alternative medicine as a replacement for conventional medicine. The research found that those having used alternative medicine tended to have higher education or report poorer health status. Dissatisfaction with conventional medicine was not a meaningful factor in the choice, but rather the majority of alternative medicine users appear to be doing so largely because "they find these healthcare alternatives to be more congruent with their own values, beliefs, and philosophical orientations toward health and life." In particular, subjects reported a holistic orientation to health, a transformational experience that changed their worldview, identification with a number of groups committed to environmentalism, feminism, psychology, and/or spirituality and personal growth, or that they were suffering from a variety of common and minor ailments – notable ones being anxiety, back problems, and chronic pain.

Authors have speculated on the socio-cultural and psychological reasons for the appeal of alternative medicines among that minority using them in lieu of conventional medicine. There are several socio-cultural reasons for the interest in these treatments centered on the low level of scientific literacy among the public at large and a concomitant increase in antiscientific attitudes and new age mysticism.[128] Related to this are vigorous marketing[129] of extravagant claims by the alternative medical community combined with inadequate media scrutiny and attacks on critics.[128][54]

There is also an increase in conspiracy theories toward conventional medicine and pharmaceutical companies, mistrust of traditional authority figures, such as the physician, and a dislike of the current delivery methods of scientific biomedicine, all of which have led patients to seek out alternative medicine to treat a variety of ailments.[54] Many patients lack access to contemporary medicine, due to a lack of private or public health insurance, which leads them to seek out lower-cost alternative medicine.[87] Medical doctors are also aggressively marketing alternative medicine to profit from this market.[129]

In addition to the social-cultural underpinnings of the popularity of alternative medicine, there are several psychological issues that are critical to its growth. One of the most critical is the placebo effect, which is a well-established observation in medicine.[130] Related to it are similar psychological effects such as the will to believe,[128] cognitive biases that help maintain self-esteem and promote harmonious social functioning,[128] and the post hoc, ergo propter hoc fallacy.[128]

Patients can also be averse to the painful, unpleasant, and sometimes-dangerous side effects of biomedical treatments. Treatments for severe diseases such as cancer and HIV infection have well-known, significant side-effects. Even low-risk medications such as antibiotics can have potential to cause life-threatening anaphylactic reactions in a very few individuals. Also, many medications may cause minor but bothersome symptoms such as cough or upset stomach. In all of these cases, patients may be seeking out alternative treatments to avoid the adverse effects of conventional treatments.[128][54]

Schofield et al., in a systematic review published in 2011, make ten recommendations which they think may increase the effectiveness of consultations in a conventional (here: oncology) setting, such as "Ask questions about CAM use at critical points in the illness trajectory"; "Respond to the person's emotional state"; and "Provide balanced, evidence-based advice". They suggest that this approach may address "... concerns surrounding CAM use [and] encourage informed decision-making about CAM and ultimately, improve outcomes for patients".[131]

CAM's popularity may be related to other factors which Edzard Ernst mentions in an interview in The Independent:

Why is it so popular, then? Ernst blames the providers, customers and the doctors whose neglect, he says, has created the opening into which alternative therapists have stepped. "People are told lies. There are 40 million websites and 39.9 million tell lies, sometimes outrageous lies. They mislead cancer patients, who are encouraged not only to pay their last penny but to be treated with something that shortens their lives. "At the same time, people are gullible. It needs gullibility for the industry to succeed. It doesn't make me popular with the public, but it's the truth.[132]

In a paper published in October 2010 entitled The public's enthusiasm for complementary and alternative medicine amounts to a critique of mainstream medicine, Ernst describes these views in greater detail and concludes:

[CAM] is popular. An analysis of the reasons why this is so points towards the therapeutic relationship as a key factor. Providers of CAM tend to build better therapeutic relationships than mainstream healthcare professionals. In turn, this implies that much of the popularity of CAM is a poignant criticism of the failure of mainstream healthcare. We should consider it seriously with a view of improving our service to patients.[133]

Physicians who practice complementary medicine usually discuss and advise patients as to available complementary therapies. Patients often express interest in mind-body complementary therapies because they offer a non-drug approach to treating some health conditions.[134] Some mind-body techniques, such as cognitive-behavioral therapy, were once considered complementary medicine, but are now a part of conventional medicine in the United States.[135]

Efforts at abstract characterizations

There is no clear and consistent definition for either alternative or complementary medicine.[25]: 17 

Self-characterization

The US National Center for Complementary and Alternative Medicine (NCCAM) defines CAM as "a group of diverse medical and healthcare systems, practices, and products, that are not currently part of conventional medicine”, in a context where conventional medicine is that which is scientifically proven.[10] This definition of CAM is widely known and used and is inclusive of many different types of therapies and products.[136][137]

The Danish Knowledge and Research Center for Alternative Medicine an independent institution under the Danish Ministry of the Interior and Health (Danish abbreviation: ViFAB) uses the term “alternative medicine” for:

  • Treatments performed by therapists that are not authorized healthcare professionals, where authorized healthcare professionals are those practicing what is proven by science.
  • Treatments performed by authorized healthcare professionals, but those based on methods otherwise used mainly outside the healthcare system, which is based on science in Denmark. People without a healthcare authorisation must be able to perform the treatments.

Institutions

The World Health Organization defines complementary and alternative medicine as a broad set of health care practices that are not part of that country's own tradition and are not integrated into the dominant health care system.[13]

In a consensus report released in 2005, entitled Complementary and Alternative Medicine in the United States, the Institute of Medicine (IOM) defined complementary and alternative medicine (CAM) as the non-dominant approach to medicine in a given culture and historical period.[12] A similar definition has been adopted by the Cochrane Collaboration,[11][138] and official government bodies such as the UK Department of Health.[139] The Cochrane Collaboration Complementary Medicine Field definition is "complementary medicine includes all such practices and ideas that are outside the domain of conventional medicine in several countries and defined by its users as preventing or treating illness, or promoting health and well-being."[138] While some herbal therapies are mainstream in Europe, but are alternative in the United States.[140]

Special terminology used by selected individuals

According to Roberta Bivens, alternative medical systems can only exist when there is a identifiable, regularized and authoritative medical orthodoxy, such as arose in the west during the nineteenth-century, to which they can function or act as an alternative.[141] Two advocates of integrative medicine claim that it also addresses alleged problems with medicine based on science, which are not addressed by CAM; Ralph Snyderman and Andrew Weil state that "integrative medicine is not synonymous with complementary and alternative medicine. It has a far larger meaning and mission in that it calls for restoration of the focus of medicine on health and healing and emphasizes the centrality of the patient-physician relationship."[142]

Academic resources

See also

References

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Further reading

World Health Organization publication

Journals dedicated to alternative medicine research

Criticism

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