CHRNA5

CHRNA5
Identifiers
Aliases	CHRNA5, LNCR2, cholinergic receptor nicotinic alpha 5 subunit
External IDs	OMIM: 118505; MGI: 87889; HomoloGene: 55485; GeneCards: CHRNA5; OMA:CHRNA5 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q25.1 Start 78,565,520 bp End 78,595,269 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 B|9 29.84 cM Start 54,888,164 bp End 54,915,063 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence gonad testicle islet of Langerhans secondary oocyte gallbladder rectum mucosa of transverse colon stromal cell of endometrium Top expressed in spermatid substantia nigra seminiferous tubule morula spermatocyte Hindgut pharynx superior cervical ganglion trigeminal nerve ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function acetylcholine receptor activity ion channel activity protein binding ligand-gated ion channel activity extracellular ligand-gated ion channel activity acetylcholine binding acetylcholine-gated cation-selective channel activity transmembrane signaling receptor activity Cellular component integral component of membrane acetylcholine-gated channel complex postsynaptic membrane membrane plasma membrane synapse cell junction dopaminergic synapse integral component of plasma membrane neuron projection Biological process response to nicotine synaptic transmission, cholinergic ion transport behavioral response to nicotine neuromuscular synaptic transmission signal transduction chemical synaptic transmission regulation of postsynaptic membrane potential excitatory postsynaptic potential ion transmembrane transport regulation of synaptic vesicle exocytosis regulation of membrane potential nervous system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1138 110835 Ensembl ENSG00000169684 ENSMUSG00000035594 UniProt P30532 Q2MKA5 RefSeq (mRNA) NM_000745 NM_001307945 NM_176844 NM_001373901 NM_001373902 RefSeq (protein) NP_000736 NP_001294874 NP_789814 NP_001360830 NP_001360831 Location (UCSC) Chr 15: 78.57 – 78.6 Mb Chr 9: 54.89 – 54.92 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-5, also known as nAChRα5, is a protein that in humans is encoded by the CHRNA5 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

Function

Nicotinic acetylcholine receptors (nAChRs), such as CHRNA5, are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits. CHRNA5 is a candidate gene for predisposition to nicotine dependence and to lung cancer risk. Polymorphisms in the CHRNA5 promoter are functionally associated with CHRNA5 transcript levels in lung tissue.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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|alt=Nicotine Activity on Dopaminergic Neurons edit]]

Nicotine Activity on Dopaminergic Neurons edit

See also

• Nicotinic acetylcholine receptor

Further reading

• Hogg RC, Raggenbass M, Bertrand D (2003). "Nicotinic acetylcholine receptors: from structure to brain function". Rev. Physiol. Biochem. Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 147: 1–46. doi:10.1007/s10254-003-0005-1. ISBN 978-3-540-01365-5. PMID 12783266.
• Anand R, Lindstrom J (1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988.
• Chini B, Clementi F, Hukovic N, Sher E (1992). "Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines". Proc. Natl. Acad. Sci. U.S.A. 89 (5): 1572–6. doi:10.1073/pnas.89.5.1572. PMC 48494. PMID 1542648.
• Raimondi E; Rubboli F; Moralli D; et al. (1992). "Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits". Genomics. 12 (4): 849–50. doi:10.1016/0888-7543(92)90324-L. PMID 1572664. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
• Elliott KJ; Ellis SB; Berckhan KJ; et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–28. doi:10.1007/BF02736842. PMID 8906617. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
• Groot Kormelink PJ, Luyten WH (1997). "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32". FEBS Lett. 400 (3): 309–14. doi:10.1016/S0014-5793(96)01383-X. PMID 9009220.
• Navaneetham D, Penn A, Howard J, Conti-Fine BM (1997). "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses". Cell. Mol. Biol. (Noisy-le-grand). 43 (3): 433–42. PMID 9193799.
• Gerzanich V, Wang F, Kuryatov A, Lindstrom J (1998). "alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors". J. Pharmacol. Exp. Ther. 286 (1): 311–20. PMID 9655874.
• Lentz TL (2000). "Nicotine binding to native and substituted peptides comprising residues 188-207 of nicotinic acetylcholine receptor alpha1, alpha2, alpha3, alpha4, alpha5, and alpha7 subunits". Biochem. Biophys. Res. Commun. 268 (2): 480–4. doi:10.1006/bbrc.2000.2155. PMID 10679230.
• Groot-Kormelink PJ, Boorman JP, Sivilotti LG (2001). "Formation of functional α3β4α5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach". Br. J. Pharmacol. 134 (4): 789–96. doi:10.1038/sj.bjp.0704313. PMC 1573006. PMID 11606319.
• Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
• Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
• Soldà G; Boi S; Duga S; et al. (2005). "In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs". Gene. 345 (2): 155–64. doi:10.1016/j.gene.2004.12.005. PMID 15716100. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

External links

• CHRNA5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CHRNA5 genome location and CHRNA5 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.