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Epstein-Barr virus induced 3
Symbols EBI3 ; IL-27B; IL27B
External IDs OMIM605816 MGI1354171 HomoloGene4207 GeneCards: EBI3 Gene
RNA expression pattern
PBB GE EBI3 219424 at tn.png
More reference expression data
Species Human Mouse
Entrez 10148 50498
Ensembl ENSG00000105246 ENSMUSG00000003206
UniProt Q14213 O35228
RefSeq (mRNA) NM_005755 NM_015766
RefSeq (protein) NP_005746 NP_056581
Location (UCSC) Chr 19:
4.23 – 4.24 Mb
Chr 17:
55.95 – 55.96 Mb
PubMed search [1] [2]

Epstein-Barr virus induced gene 3, also known as interleukin-27 subunit beta or IL-27B, is a protein which in humans is encoded by the EBI3 gene.[1][2]


This gene was identified by the induction of its expression in B lymphocytes by Epstein-Barr virus infection. The protein encoded by this gene is a secreted glycoprotein, which is a member of the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). It plays a role in regulating cell-mediated immune responses.[3]

EBI3 is a subunit in 2 distinct heterodimeric cytokines: interleukin-27 (IL27) and IL35. IL27 is composed of p28 (IL27) and EBI3. IL27 can trigger signaling in T cells, B cells, and myeloid cells.[4] IL35, an inhibitory cytokine involved in regulatory T-cell function, is composed of EBI3 and the p35 subunit of IL12.[5][3]


  1. ^ "Entrez Gene: EBI3 Epstein-Barr virus induced gene 3". 
  2. ^ Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M (February 1996). "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes". J. Virol. 70 (2): 1143–53. PMC 189923. PMID 8551575. 
  3. ^ a b Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA (November 2007). "The inhibitory cytokine IL-35 contributes to regulatory T-cell function". Nature 450 (7169): 566–9. doi:10.1038/nature06306. PMID 18033300. 
  4. ^ Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, Lee J, de Sauvage FJ, Ghilardi N (September 2006). "Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells". Nat. Immunol. 7 (9): 929–36. doi:10.1038/ni1375. PMID 16906167. 
  5. ^ Niedbala W, Wei XQ, Cai B, Hueber AJ, Leung BP, McInnes IB, Liew FY (November 2007). "IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells". Eur. J. Immunol. 37 (11): 3021–9. doi:10.1002/eji.200737810. PMID 17874423. 

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