Interleukin 19

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IL19
IL19 Crystal Structure.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL19, IL-10C, MDA1, NG.1, ZMDA1, Interleukin 19, IL-19
External IDsMGI: 1890472 HomoloGene: 17813 GeneCards: IL19
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for IL19
Genomic location for IL19
Band1q32.1Start206,798,870 bp[1]
End206,842,981 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013371
NM_153758

NM_001009940
NM_001355135

RefSeq (protein)

NP_037503
NP_715639

NP_001009940
NP_001342064

Location (UCSC)Chr 1: 206.8 – 206.84 MbChr 1: 130.93 – 130.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin 19 (IL19) is a protein that in humans is encoded by the IL19 gene.[5]

Function[edit]

The protein encoded by this gene is a cytokine that belongs to the IL-10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the interleukin-20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.[5]

Interleukin-19 is a cytokine that belongs to the IL-10 family of cytokines along with several other interleukins including IL-10, IL-20, IL-22, IL-24, IL-26, and several virus-encoded cytokines. It signals through the same cell surface receptor (IL-20R) that is used by IL-20 and IL-24. The IL-19 gene is expressed in resting monocytes and B cells. It is up-regulated in monocytes following stimulation with granulocyte-macrophage colony-stimulating factor (GM-CSF), lipopolysaccharide, or Pam3CSK4.[6] and [7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142224 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000016524 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: Interleukin 19". 
  6. ^ Chang C, Magracheva E, Kozlov S, Fong S, Tobin G, Kotenko S, Wlodawer A, Zdanov A (Jan 2003). "Crystal structure of interleukin-19 defines a new subfamily of helical cytokines". The Journal of Biological Chemistry. 278 (5): 3308–13. doi:10.1074/jbc.M208602200. PMID 12403790. 
  7. ^ Kragstrup TW, Andersen T, Holm C, Schiøttz-Christensen B, Jurik AG, Hvid M, Deleuran B (May 2015). "Toll-like receptor 2 and 4 induced interleukin-19 dampens immune reactions and associates inversely with spondyloarthritis disease activity". Clinical and Experimental Immunology. 180 (2): 233–42. doi:10.1111/cei.12577. PMC 4408158Freely accessible. PMID 25639337. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.