Interleukin 24

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IL24
Identifiers
Aliases IL24, C49A, FISP, IL10B, MDA7, MOB5, ST16, IL-24, interleukin 24
External IDs OMIM: 604136 MGI: 2135548 HomoloGene: 4991 GeneCards: 11009
RNA expression pattern
PBB GE IL24 206569 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001185156
NM_001185157
NM_001185158
NM_006850
NM_181339

NM_053095

RefSeq (protein)

NP_001172085.1
NP_001172086.1
NP_001172087.1
NP_006841.1

NP_444325.2

Location (UCSC) Chr 1: 206.9 – 206.9 Mb Chr 1: 130.88 – 130.89 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin 24 (IL-24) is a protein that in humans is encoded by the IL24 gene.

IL-24 is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control in cell survival and proliferation by inducing rapid activation of particular transcription factors called STAT1 and STAT3. This cytokine is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells[3] and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, psoriasis and cancer.[4] Several studies have shown that cell death occurs in cancer cells/cell lines following exposure to IL-24.[5][6] The gene for IL-24 is located on chromosome 1 in humans.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Poindexter NJ, Walch ET, Chada S, Grimm EA (September 2005). "Cytokine induction of interleukin-24 in human peripheral blood mononuclear cells". J. Leukoc. Biol. 78 (3): 745–52. doi:10.1189/jlb.0205116. PMID 16000394. 
  4. ^ Wang M, Liang P (February 2005). "Interleukin-24 and its receptors". Immunology. 114 (2): 166–70. doi:10.1111/j.1365-2567.2005.02094.x. PMC 1782067free to read. PMID 15667561. 
  5. ^ Fisher PB, Gopalkrishnan RV, Chada S, Ramesh R, Grimm EA, Rosenfeld MR, Curiel DT, Dent P (2003). "mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic". Cancer Biol. Ther. 2 (4 Suppl 1): S23–37. PMID 14508078. 
  6. ^ Sauane M, Lebedeva IV, Su ZZ, Choo HT, Randolph A, Valerie K, Dent P, Gopalkrishnan RV, Fisher PB (May 2004). "Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways". Cancer Res. 64 (9): 2988–93. doi:10.1158/0008-5472.CAN-04-0200. PMID 15126330. 
  7. ^ IL24 GeneCard

External links[edit]