Interleukin 34

From Wikipedia, the free encyclopedia
Jump to: navigation, search
IL34
4dkc.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases IL34, C16orf77, IL-34, Interleukin 34
External IDs MGI: 1923777 HomoloGene: 12648 GeneCards: IL34
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001172771
NM_001172772
NM_152456

NM_001135100
NM_029646

RefSeq (protein)

NP_001166242
NP_001166243
NP_689669

NP_001128572.1
NP_083922.1
NP_001128572
NP_083922

Location (UCSC) Chr 16: 70.58 – 70.66 Mb Chr 8: 110.74 – 110.81 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin 34 (IL-34) is a protein belonging to a group of cytokines called interleukins. It was originally identified in humans, by large scale screening of secreted proteins; chimpanzee, murine, rat and chicken interleukin 34 orthologs have also been found. The protein is composed of 241 amino acids, 39 kilodaltons in mass, and forms homodimers. IL-34 increases growth or survival of immune cells known as monocytes; it elicits its activity by binding the Colony stimulating factor 1 receptor.

Messenger RNA (mRNA) expression of human IL-34 is most abundant in spleen but occurs in several other tissues: thymus, liver, small intestine, colon, prostate gland, lung, heart, brain, kidney, testes, and ovary. The discovery of IL-34 protein in the red pulp of the spleen suggests involvement in growth and development of myeloid cells, consistent with its activity on monocytes. [3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lin H, Lee E, Hestir K, et al. (May 2008). "Discovery of a cytokine and its receptor by functional screening of the extracellular proteome". Science. 320 (5877): 807–11. doi:10.1126/science.1154370. PMID 18467591. 

External links[edit]

Interleukin-34 at the US National Library of Medicine Medical Subject Headings (MeSH)