Interleukin 34

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Interleukin 34
Crystal Structure of Human Interleukin-34 dimer. PDB 4dkc
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols IL34 ; C16orf77; IL-34
External IDs OMIM612081 MGI1923777 HomoloGene12648 GeneCards: IL34 Gene
Species Human Mouse
Entrez 146433 76527
Ensembl ENSG00000157368 ENSMUSG00000031750
UniProt Q6ZMJ4 Q8R1R4
RefSeq (mRNA) NM_001172771 NM_001135100
RefSeq (protein) NP_001166242 NP_001128572
Location (UCSC) Chr 16:
70.58 – 70.66 Mb
Chr 8:
110.74 – 110.81 Mb
PubMed search [1] [2]

Interleukin-34, or IL-34 is a protein belonging to a group of cytokines called interleukins. It was originally identified in humans, by large scale screening of secreted proteins; chimpanzee, murine, rat and chicken IL-34 orthologs have also been found. The protein is composed of 241 amino acids, 39 kilodaltons in mass, and forms homodimers. IL-34 increases growth or survival of immune cells known as monocytes; it elicits its activity by binding the Colony stimulating factor 1 receptor.

Messenger RNA (mRNA) expression of human IL-34 is most abundant in spleen but occurs in several other tissues: thymus, liver, small intestine, colon, prostate gland, lung, heart, brain, kidney, testes, and ovary. The discovery of IL-34 protein in the red pulp of the spleen suggests involvement in growth and development of myeloid cells, consistent with its activity on monocytes. [1]


  1. ^ Lin H, Lee E, Hestir K, et al. (May 2008). "Discovery of a cytokine and its receptor by functional screening of the extracellular proteome". Science 320 (5877): 807–11. doi:10.1126/science.1154370. PMID 18467591. 

External links[edit]

Interleukin-34 at the US National Library of Medicine Medical Subject Headings (MeSH)