Interleukin 34

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IL34
4dkc.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL34, C16orf77, IL-34, Interleukin 34
External IDsMGI: 1923777 HomoloGene: 12648 GeneCards: IL34
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for IL34
Genomic location for IL34
Band16q22.1Start70,579,895 bp[1]
End70,660,682 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001172771
NM_001172772
NM_152456

NM_001135100
NM_029646

RefSeq (protein)

NP_001166242
NP_001166243
NP_689669

NP_001128572
NP_083922

Location (UCSC)Chr 16: 70.58 – 70.66 MbChr 8: 110.74 – 110.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin 34 (IL-34) is a protein belonging to a group of cytokines called interleukins. It was originally identified in humans, by large scale screening of secreted proteins; chimpanzee, murine, rat and chicken interleukin 34 orthologs have also been found. The protein is composed of 241 amino acids, 39 kilodaltons in mass, and forms homodimers. IL-34 increases growth or survival of immune cells known as monocytes; it elicits its activity by binding the Colony stimulating factor 1 receptor.

Messenger RNA (mRNA) expression of human IL-34 is most abundant in spleen but occurs in several other tissues: thymus, liver, small intestine, colon, prostate gland, lung, heart, brain, kidney, testes, and ovary. The discovery of IL-34 protein in the red pulp of the spleen suggests involvement in growth and development of myeloid cells, consistent with its activity on monocytes. [5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157368 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031750 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Lin H, Lee E, Hestir K, et al. (May 2008). "Discovery of a cytokine and its receptor by functional screening of the extracellular proteome". Science. 320 (5877): 807–11. doi:10.1126/science.1154370. PMID 18467591. 

External links[edit]

Interleukin-34 at the US National Library of Medicine Medical Subject Headings (MeSH)