GABRB2

GABRB2
Identifiers
Aliases	GABRB2, gamma-aminobutyric acid type A receptor beta2 subunit, ICEE2, gamma-aminobutyric acid type A receptor subunit beta2, DEE92
External IDs	OMIM: 600232; MGI: 95620; HomoloGene: 7327; GeneCards: GABRB2; OMA:GABRB2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	161,549,044 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	42,519,855 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; endothelial cell; ; lateral nuclear group of thalamus; ; postcentral gyrus; ; middle temporal gyrus; ; entorhinal cortex; ; buccal mucosa cell; ; external globus pallidus; ; superior frontal gyrus; ; primary visual cortex;
	Top expressed in
	lateral geniculate nucleus; ; medial geniculate nucleus; ; medial dorsal nucleus; ; globus pallidus; ; cerebellar vermis; ; lateral septal nucleus; ; lobe of cerebellum; ; lateral hypothalamus; ; anterior amygdaloid area; ; ventromedial nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	inhibitory extracellular ligand-gated ion channel activity; ion channel activity; GABA receptor activity; chloride channel activity; extracellular ligand-gated ion channel activity; GABA-A receptor activity; transmembrane signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; GABA-gated chloride ion channel activity;
Cellular component	integral component of membrane; cytosol; GABA-A receptor complex; postsynaptic membrane; membrane; plasma membrane; integral component of plasma membrane; synapse; chloride channel complex; cell junction; GABA receptor complex; extracellular exosome; cytoplasmic vesicle membrane; cytoplasmic vesicle; neuron projection; GABA-ergic synapse; integral component of postsynaptic specialization membrane;
Biological process	gamma-aminobutyric acid signaling pathway; negative regulation of neuron apoptotic process; chemical synaptic transmission; cochlea development; regulation of neuron apoptotic process; neuron development; chloride transmembrane transport; synaptic transmission, GABAergic; hearing; ion transport; inner ear receptor cell development; chloride transport; innervation; negative regulation of neuron death; cellular response to histamine; transport; signal transduction; ion transmembrane transport; regulation of membrane potential; nervous system process; regulation of postsynaptic membrane potential; inhibitory synapse assembly;
	Sources:Amigo / QuickGO
Orthologs
	2561
	14401
	ENSG00000145864
	ENSMUSG00000007653
	P47870
	P63137
	NM_000813; NM_021911; NM_001371727
	NM_008070; NM_001347314; NM_001362646; NM_001362647; NM_001362649
	NP_000804; NP_068711; NP_001358656
	NP_001334243; NP_032096; NP_001349575; NP_001349576; NP_001349578
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-aminobutyric acid receptor subunit beta-2 is a protein that in humans is encoded by the GABRB2 gene.^[5]^[6]

Template:PBB Summary

Interactions

GABRB2 has been shown to interact with TRAK2.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145864 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000007653 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Russek SJ, Farb DH (Mar 1995). "Mapping of the beta 2 subunit gene (GABRB2) to microdissected human chromosome 5q34-q35 defines a gene cluster for the most abundant GABAA receptor isoform". Genomics. 23 (3): 528–33. doi:10.1006/geno.1994.1539. PMID 7851879.
^ "Entrez Gene: GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2".
^ Beck, Mike; Brickley Kieran; Wilkinson Helen L; Sharma Seema; Smith Miriam; Chazot Paul L; Pollard Simon; Stephenson F Anne (Aug 2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". J. Biol. Chem. 277 (33). United States: 30079–90. doi:10.1074/jbc.M200438200. ISSN 0021-9258. PMID 12034717. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

External links

GABRB2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145864 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000007653 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7851879-5] Russek SJ, Farb DH (Mar 1995). "Mapping of the beta 2 subunit gene (GABRB2) to microdissected human chromosome 5q34-q35 defines a gene cluster for the most abundant GABAA receptor isoform". Genomics. 23 (3): 528–33. doi:10.1006/geno.1994.1539. PMID 7851879.

[entrez-6] "Entrez Gene: GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2".

[pmid12034717-7] Beck, Mike; Brickley Kieran; Wilkinson Helen L; Sharma Seema; Smith Miriam; Chazot Paul L; Pollard Simon; Stephenson F Anne (Aug 2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". J. Biol. Chem. 277 (33). United States: 30079–90. doi:10.1074/jbc.M200438200. ISSN 0021-9258. PMID 12034717. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

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GABRB2

Interactions

See also

References

Further reading

External links