HTR3A

HTR3A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4PIR
Identifiers
Aliases	HTR3A, 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3, 5-hydroxytryptamine receptor 3A
External IDs	OMIM: 182139; MGI: 96282; HomoloGene: 671; GeneCards: HTR3A; OMA:HTR3A - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	113,990,313 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	48,822,399 bp
RNA expression pattern
	Top expressed in
	spinal ganglia; ; testicle; ; trigeminal ganglion; ; lymph node; ; islet of Langerhans; ; appendix; ; gingival epithelium; ; muscle layer of sigmoid colon; ; caudate nucleus; ; minor salivary glands;
	Top expressed in
	lumbar spinal ganglion; ; Rostral migratory stream; ; facial motor nucleus; ; medial ganglionic eminence; ; right ventricle; ; embryo; ; carotid body; ; embryo; ; dentate gyrus of hippocampal formation granule cell; ; retinal pigment epithelium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; ligand-gated ion channel activity; serotonin binding; extracellular ligand-gated ion channel activity; serotonin-gated cation-selective channel activity; ion channel activity; transmembrane signaling receptor activity;
Cellular component	cytoplasm; integral component of membrane; postsynaptic membrane; membrane; plasma membrane; synapse; axon; cell junction; soma; serotonin-activated cation-selective channel complex; cleavage furrow; glutamatergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane; integral component of plasma membrane; neuron projection;
Biological process	response to cocaine; cellular response to growth factor stimulus; ion transport; response to ethanol; positive regulation of ion transmembrane transporter activity; signal transduction; ion transmembrane transport; serotonin receptor signaling pathway; chemical synaptic transmission; regulation of membrane potential; nervous system process;
	Sources:Amigo / QuickGO
Orthologs
	3359
	15561
	ENSG00000166736
	ENSMUSG00000032269
	P46098
	P23979
	NM_000869; NM_001161772; NM_213621
	NM_001099644; NM_013561
	NP_000860; NP_001155244; NP_998786
	NP_001093114; NP_038589
	Wikidata
View/Edit Human	View/Edit Mouse

5-hydroxytryptamine receptor 3A is a protein that in humans is encoded by the HTR3A gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166736 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032269 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Weiss B, Mertz A, Schrock E, Koenen M, Rappold G (Feb 1996). "Assignment of a human homolog of the mouse Htr3 receptor gene to chromosome 11q23.1-q23.2". Genomics. 29 (1): 304–5. doi:10.1006/geno.1995.1254. PMID 8530095.
^ Kelley SP, Dunlop JI, Kirkness EF, Lambert JJ, Peters JA (Jul 2003). "A cytoplasmic region determines single-channel conductance in 5-HT3 receptors". Nature. 424 (6946): 321–4. doi:10.1038/nature01788. PMID 12867984.

External links

HTR3A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166736 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032269 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8530095-5] Weiss B, Mertz A, Schrock E, Koenen M, Rappold G (Feb 1996). "Assignment of a human homolog of the mouse Htr3 receptor gene to chromosome 11q23.1-q23.2". Genomics. 29 (1): 304–5. doi:10.1006/geno.1995.1254. PMID 8530095.

[pmid12867984-6] Kelley SP, Dunlop JI, Kirkness EF, Lambert JJ, Peters JA (Jul 2003). "A cytoplasmic region determines single-channel conductance in 5-HT3 receptors". Nature. 424 (6946): 321–4. doi:10.1038/nature01788. PMID 12867984.

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HTR3A

See also

References

Further reading

External links