Interleukin 12 receptor, beta 2 subunit

IL12RB2
Identifiers
Aliases	IL12RB2, Interleukin 12 receptor, beta 2 subunit, interleukin 12 receptor subunit beta 2
External IDs	OMIM: 601642; MGI: 1270861; HomoloGene: 1197; GeneCards: IL12RB2; OMA:IL12RB2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	67,398,724 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	67,353,172 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; testicle; ; body of pancreas; ; Achilles tendon; ; prefrontal cortex; ; gonad; ; granulocyte; ; lymph node; ; cingulate gyrus;
	Top expressed in
	zygote; ; secondary oocyte; ; gray matter layer of cerebellum; ; morula; ; blastocyst; ; thymus; ; neural layer of retina; ; primary oocyte; ; muscle of thigh; ; striated muscle tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine receptor activity; protein kinase binding; cytokine binding;
Cellular component	integral component of membrane; external side of plasma membrane; integral component of plasma membrane; plasma membrane; membrane; receptor complex;
Biological process	response to lipopolysaccharide; cell surface receptor signaling pathway; positive regulation of cell population proliferation; positive regulation of interferon-gamma production; peptidyl-tyrosine phosphorylation; response to cytokine; interleukin-12-mediated signaling pathway; interleukin-35-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3595
	16162
	ENSG00000081985
	ENSMUSG00000018341
	Q99665
	P97378
NM_001258214; NM_001258215; NM_001258216; NM_001559; NM_001319233;
	NM_001374259
	NM_008354; NM_001311141
NP_001245143; NP_001245144; NP_001245145; NP_001306162; NP_001550;
	NP_001361188
	NP_001298070; NP_032380
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene.^[5] IL12RB2 orthologs^[6] have been identified in all mammals for which complete genome data are available.

Template:PBB Summary

Interactions

Interleukin 12 receptor, beta 2 subunit has been shown to interact with Janus kinase 2.^[7]

RNA editing

The mRNA of this protein is subject to RNA editing.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000081985 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018341 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: IL12RB2 interleukin 12 receptor, beta 2".
^ "OrthoMaM phylogenetic marker: IL12RB2 coding sequence".
^ Yamamoto, K; Shibata F; Miura O; Kamiyama R; Hirosawa S; Miyasaka N (April 1999). "Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus". Biochem. Biophys. Res. Commun. 257 (2). UNITED STATES: 400–4. doi:10.1006/bbrc.1999.0479. ISSN 0006-291X. PMID 10198225. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

RNA editing

References

Further reading