Interleukin 12 receptor, beta 2 subunit

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IL12RB2
Identifiers
Aliases IL12RB2, Interleukin 12 receptor, beta 2 subunit, interleukin 12 receptor subunit beta 2
External IDs MGI: 1270861 HomoloGene: 1197 GeneCards: IL12RB2
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for IL12RB2
Genomic location for IL12RB2
Band 1p31.3 Start 67,307,364 bp[1]
End 67,396,900 bp[1]
RNA expression pattern
PBB GE IL12RB2 206999 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001258214
NM_001258215
NM_001258216
NM_001559
NM_001319233

NM_008354
NM_001311141

RefSeq (protein)

NP_001245143
NP_001245144
NP_001245145
NP_001306162
NP_001550

NP_001298070
NP_032380

Location (UCSC) Chr 1: 67.31 – 67.4 Mb Chr 6: 67.29 – 67.38 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene.[5] IL12RB2 orthologs[6] have been identified in all mammals for which complete genome data are available.

The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The co-expression of this and IL12Rβ1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. While the IL12Rβ1 subunit is constitutively expressed, the expression of the IL12RB2 gene is up-regulated by interferon gamma. In Th1 cells, IL-12 signaling through the IL12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation. The IL12Rβ2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules.[7] The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.[5]

Interactions[edit]

Interleukin 12 receptor, beta 2 subunit has been shown to interact with Janus kinase 2.[8]

RNA editing[edit]

The mRNA of this protein is subject to RNA editing.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000081985 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018341 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: IL12RB2 interleukin 12 receptor, beta 2". 
  6. ^ "OrthoMaM phylogenetic marker: IL12RB2 coding sequence". 
  7. ^ Koch MA, Thomas KR, Perdue NR, Smigiel KS, Srivastava S, Campbell DJ (September 2012). "T-bet(+) Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2". Immunity. 37 (3): 501–10. doi:10.1016/j.immuni.2012.05.031. PMID 22960221. 
  8. ^ Yamamoto, K; Shibata F; Miura O; Kamiyama R; Hirosawa S; Miyasaka N (Apr 1999). "Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus". Biochem. Biophys. Res. Commun. UNITED STATES. 257 (2): 400–4. doi:10.1006/bbrc.1999.0479. ISSN 0006-291X. PMID 10198225. 

Further reading[edit]