CHRNA10

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CHRNA10
Identifiers
AliasesCHRNA10, cholinergic receptor nicotinic alpha 10 subunit
External IDsMGI: 3609260 HomoloGene: 56886 GeneCards: CHRNA10
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for CHRNA10
Genomic location for CHRNA10
Band11p15.4Start3,665,587 bp[1]
End3,671,384 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001303034
NM_001303035
NM_020402

NM_001081424

RefSeq (protein)

NP_001289963
NP_001289964
NP_065135

n/a

Location (UCSC)Chr 11: 3.67 – 3.67 MbChr 7: 102.11 – 102.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-10, also known as nAChRα10 and cholinergic receptor nicotinic alpha 10, is a protein that in humans is encoded by the CHRNA10 gene.[5] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

This nAchR subunit is required for the normal function of the olivocochlear system which is part of the auditory system.[6] Furthermore, selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000129749 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066279 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Lustig LR, Peng H, Hiel H, Yamamoto T, Fuchs PA (May 2001). "Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10)". Genomics. 73 (3): 272–83. doi:10.1006/geno.2000.6503. PMID 11350119.
  6. ^ Vetter DE, Katz E, Maison SF, Taranda J, Turcan S, Ballestero J, Liberman MC, Elgoyhen AB, Boulter J (December 2007). "The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system". Proc. Natl. Acad. Sci. U.S.A. 104 (51): 20594–9. doi:10.1073/pnas.0708545105. PMC 2154476. PMID 18077337.
  7. ^ Vincler M, Wittenauer S, Parker R, Ellison M, Olivera BM, McIntosh JM (November 2006). "Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors". Proc. Natl. Acad. Sci. U.S.A. 103 (47): 17880–4. doi:10.1073/pnas.0608715103. PMC 1635975. PMID 17101979.

External links[edit]