Nettie Stevens

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Nettie Stevens
Nettie Stevens.jpg
Born Nettie Maria Stevens
(1861-07-07)July 7, 1861
Cavendish, Vermont, United States
Died May 4, 1912(1912-05-04) (aged 50)
Baltimore, Maryland, United States
Fields Genetics
Education Westford Academy
Alma mater Westfield Normal School
Stanford University
Bryn Mawr College
Doctoral students Alice Middleton Boring
Known for XY sex-determination system
Influences Edmund Beecher Wilson
Thomas Hunt Morgan

Nettie Maria Stevens (July 7, 1861 – May 4, 1912) was an early American geneticist. In 1906, she discovered that male beetles produce two kinds of sperm, one with a large chromosome and one with a small chromosome. When the sperm with the large chromosome fertilized eggs, they produced female offspring, and when the sperm with the small chromosome fertilized eggs, they produced male offspring. This pattern was observed in other animals, including humans, and became known as the XY sex-determination system. Edmund Beecher Wilson independently made the same discovery.[1][2][3]

Early life[edit]

Nettie Maria Stevens was born on July 7, 1861, in Cavendish, Vermont, to Julia (née Adams) and Ephraim Stevens. After the death of her mother, Stevens's father remarried, and the family moved to Westford, Massachusetts. She graduated from Westford Academy in 1880.

Stevens taught high school and was a librarian. Her teaching duties included courses in physiology and zoology, as well as mathematics, Latin, and English. Her interest in zoology may have been influenced by taking a teacher training course she attended on Martha's Vineyard in the 1890s.[4]

Education[edit]

After teaching for three terms, she continued her education at Westfield Normal School (now Westfield State University) completing the four-year course in only two years and graduating with the highest scores in her class.[5]

After she graduated top in her class, she attended Stanford University, where she received her B.A. in 1899 and her M.A. in 1900. She also completed one year of graduate work in physiology under Professor Jenkins and histology/cytology under Professor McFarland.[6] Stevens continued her studies in cytology at Bryn Mawr College, where she obtained her Ph.D. and was influenced by the work of the previous head of the biology department, Edmund Beecher Wilson, and by that of his successor, Thomas Hunt Morgan.[5]

In her first year at Bryn Mawr, Stevens received a graduate scholarship in biology. The following year, she was named a President's European Fellow, and studied at the University of Würzburg, Germany.[1] She also studied marine organisms at Helgoland and Naples Zoological Station.[6][7] After receiving her Ph.D. from Bryn Mawr, Stevens was given an assistantship at the Carnegie Institute of Washington in the year 1904–1905. Several subsequent studies of germ cells in aphids appeared as a result. One paper (1905) won Stevens an award of $1,000 for the best scientific paper written by a woman. Another work, "Studies in Spermatogenesis," highlighted her entry into the increasingly promising focus of sex-determination studies and chromosomal inheritance.[1] It was at this institute that Stevens had her sex determination work published as a report in 1905.[2] At Bryn Mawr, Stevens focused on topics such as the regeneration in primitive multicellular organisms, the structure of single cell organisms, the development of sperm and eggs, germ cells of insects,[1] and cell division in sea urchins and worms. In 1908, Stevens received the Alice Freeman Palmer Fellowship from the Association of Collegiate Alumnae, now the American Association of University Women. During her fellowship year, Stevens studied at the Naples Zoological Station and the University of Wurzburg in addition to visiting laboratories throughout Europe.[8]

Career[edit]

Nettie Stevens's microscope, Bryn Mawr College.

Stevens was one of the first American women to be recognized for her contribution to science. Her research was done at Bryn Mawr College. Her highest rank attained was the associate in experimental morphology (1905–1912). She discovered that, in some species, chromosomes are different among the sexes using observations of insect chromosomes. The discovery was the first time that observable differences of chromosomes could be linked to an observable difference in physical attributes (i.e., whether an individual is male or female). This work was done in 1905. The experiments done to determine this used a range of insects. She identified the Y chromosome in the mealworm Tenebrio. She deduced that the chromosomal basis of sex depended on the presence or absence of the Y chromosome. She did not start her research until her thirties and completed her Ph.D. in 1903. She successfully expanded the fields of genetics, cytology and embryology.[1]

Stevens failed to gain a full regular university position. However, she achieved a research career at leading marine stations and laboratories. Her record of 38 publications includes several major contributions which further the emergence of ideas of chromosomal heredity. As a result of her research, Stevens provided critical evidence for Mendelian and chromosomal theories of inheritance.[1]

Stevens worked to be able to become a full researcher at Bryn Mawr. However, before she could take the research professorship offered to her, she died May 4, 1912, of breast cancer at Johns Hopkins Hospital.[7]

Following her death, Thomas Hunt Morgan wrote an extensive obituary for the journal Science.[9] In an earlier letter of recommendation he wrote, "Of the graduate students that I have had during the last twelve years I have had no one that was as capable and independent in research as Miss Stevens."[10]

Stevens was the first to recognize that females have two large sex chromosomes. Wilson did not see this because he performed tests only on the testes because eggs are too fatty for the old staining procedures. Wilson reissued his original paper and thanked Stevens for this finding.

Stevens at Bryn Mawr was breeding Drosophila melanogaster in the laboratory some years before Morgan adopted it as his model organism.[11]

Death[edit]

At 50 years old, and only 9 years after completing her Ph.D., Stevens died of breast cancer on May 4, 1912 in Baltimore, Maryland. Her career span was short, but she published about 40 papers.[12] Nettie Maria Stevens was buried in the Westford, Massachusetts, cemetery alongside the graves of her father, Ephraim, and her sister, Emma.[6]

Quotes[edit]

Her single-mindedness and devotion, combined with keen powers of observation; her thoughtfulness and patience, united to a well-balanced judgment, account, in part, for her remarkable accomplishment.

— Thomas Hunt Morgan, in an obituary note following Stevens's death in 1912[5]

Modern cytological work involves an intricacy of detail, the significance of which can be appreciated by the specialist alone; but Miss Stevens had a share in a discovery of importance, and her work will be remembered for this, when the minutiae of detailed investigations that she carried out have become incorporated in the general body of the subject.

— Thomas Hunt Morgan, following Stevens's death in 1912 (The Scientific Work of Miss N. M. Stevens. Science, Vol. 36 (No. 928), October, 1912)[5]

References[edit]

  1. ^ a b c d e f Brush, Stephen G. (June 1978). "Nettie M. Stevens and the Discovery of Sex Determination by Chromosomes". Isis 69 (2): 162–172. 
  2. ^ a b "Nettie Maria Stevens – DNA from the Beginning". www.dnaftb.org. Retrieved 2016-07-07. 
  3. ^ John L. Heilbron (ed.), The Oxford Companion to the History of Modern Science, Oxford University Press, 2003, "genetics".
  4. ^ Hagen, Joel. Nettie Stevens and the Problem of Sex Determination. Minneapolis: University of Minnesota Press. pp. 37–47. 
  5. ^ a b c d "Nettie Maria Stevens (1861–1912)". The Marine Biological Laboratory. Archived from the original on March 31, 2013. Retrieved August 18, 2013. 
  6. ^ a b c "Nettie Maria Stevens – Turn-of-the-century Stanford alumna paved path for women in biology" (PDF). Stanford Historical Society. Archived (PDF) from the original on July 5, 2010. Retrieved August 18, 2013. 
  7. ^ a b Gilgenkrantz, Simone (October 15, 2008). "Nettie Maria Stevens (1861–1912)" (in French). Clérey-sur-Brénon, France: Médecine/Sciences. Archived from the original on August 17, 2013. Retrieved August 18, 2013. 
  8. ^ Maltby, Margaret (1929). History of the Fellowships Awarded by the American Association of University Women. American Association of University Women. pp. 41–42. 
  9. ^ Morgan, T.H. (October 12, 1912). "The Scientific Work of Miss N. M. Stevens". Science 36 (298): 468–70. doi:10.1126/science.36.928.468. JSTOR 1636618. 
  10. ^ Wessel, Gary M. (September 13, 2011). "Y does it work this way?" (PDF). Molecular Reproduction and Development (Wiley) 78 (9). doi:10.1002/mrd.21390. Retrieved August 20, 2013. 
  11. ^ Lois N. Magner, A History of the Life Sciences, 3rd ed., Marcel Dekker, 2002, p. 346.
  12. ^ "Nettie Stevens: A Discoverer of Sex Chromosomes". Nature. Archived from the original on March 14, 2016. Retrieved July 6, 2016. 

Further reading[edit]

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