Philippa Marrack

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Philippa "Pippa" Marrack
Born (1945-06-28) 28 June 1945 (age 73)
Ewell, England
Alma materNew Hall, Cambridge
Cambridge University
University of California, San Diego
Known forT cells, autoimmune disease
Spouse(s)John W. Kappler
AwardsMember, National Academy of Sciences (1989)

Louisa Gross Horwitz Prize (1995)
Dickson Prize (1996)
Fellow, Royal Society (1997)
L'Oréal-UNESCO Award for Women in Science (2004)

National Women's Hall of Fame (2015)
Scientific career
InstitutionsNational Jewish Health
Doctoral advisorAlan Munro

Philippa "Pippa" Marrack FRS (born 28 June 1945) is an English biologist, based in the United States, best known for her research into T cell development, T cell apoptosis and survival, adjuvants, autoimmune disease, and for identifying superantigens, the mechanism behind toxic shock syndrome.[1] She collaborates with her husband, John W. Kappler.


Marrack was born in Ewell, England on 28 June 1945.[2] She completed both undergraduate (1967) and PhD (1970) work at New Hall, Cambridge. During her PhD, she worked at the MRC Laboratory of Molecular Biology with Alan Munro, where she began to study the differences between T cells and B cells.

She later did postdoctoral work with Richard Dutton at the University of California, San Diego.

Her first faculty position was with the University of Rochester, followed by National Jewish Health, Denver, Colorado and the University of Colorado.

Significant papers[edit]

  • J.W. Kappler, M. Roehm, P. Marrack, "T cell tolerance by clonal elimination in the thymus," Cell, v.49, n.2, pp. 273–80 (1987)
  • P. Marrack and J. Kappler, "The Staphylococcal Enterotoxins and Their Relatives," Science, v.248 (4956), pp. 705–11 (1990).
  • J.W. Kappler, U. Staerz, J. White, P.C. Marrack, "Self-Tolerance Eliminates T Cells Specific for MIS-Modified Products of the Major Histocompatibility Complex," Nature, 332 (6159): pp. 35–40 (1988).
  • J. White, et al. (P.C. Marrack), "The V(beta)-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletions in neonatal mice," Cell, v.56, n.1, pp. 27–35 (1989).



  1. ^ Rennie, J. (1992) "Profile: Philippa Marrack and John Kappler – Keeping It In the Family", Scientific American 267(2), 43–44.
  2. ^ Yount, Lisa (2007). "Marrack, Philippa". A to Z of Women in Science and Math (Rev. ed.). New York: Infobase Pub. p. 191. ISBN 978-1-4381-0795-0.[unreliable source?]
  3. ^ "Philippa Marack To Be Honored for Lifetime Achievement in Immunology", 4 May 2003.
  4. ^ "AAI Award History".
  5. ^ Immunologist "Philippa Marrack to Receive Rockefeller University's Pearl Meister Greengard Prize", 2 November 2005.
  6. ^ Siegel-Itzkovich, Judy (29 January 2015). "Wolf Prizes in the sciences and arts presented to nine North Americans". The Jerusalem Post. Retrieved 5 May 2016.
  7. ^ Marisa Zeppieri-Caruana. "10 women honored at Hall of Fame induction". Retrieved 4 October 2015.
  8. ^ National Women's Hall of Fame. "Marrack, Philippa – National Women's Hall of Fame". Retrieved 13 February 2017.

Further reading[edit]

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