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|Philippa "Pippa" Marrack|
28 June 1945 |
|Institutions||National Jewish Health|
|Alma mater||Cambridge University
University of California, San Diego
|Doctoral advisor||Alan Munro|
|Known for||T cells, autoimmune disease|
|Notable awards||National Women's Hall of Fame (2015)|
|Spouse||John W. Kappler|
Philippa "Pippa" Marrack FRS (born 28 June 1945) is an English biologist, based in the United States, best known for her research into T cell development, T cell apoptosis and survival, adjuvants, autoimmune disease, and for identifying superantigens, the mechanism behind toxic shock syndrome. She collaborates with her husband, John W. Kappler.
Marrack was born in Ewell, England on 28 June 1945. She completed both undergraduate (1967) and Ph.D. (1970) work at New Hall, Cambridge. During her Ph.D, she worked at the MRC Laboratory of Molecular Biology with Alan Munro, where she began to study the differences between T cells and B cells.
She later did postdoctoral work with Richard Dutton at the University of California, San Diego.
- J.W. Kappler, M. Roehm, P. Marrack, "T cell tolerance by clonal elimination in the thymus," Cell, v.49, n.2, pp. 273–80 (1987)
- P. Marrack and J. Kappler, "The Staphylococcal Enterotoxins and Their Relatives," Science, v.248 (4956), pp. 705–11 (1990).
- J.W. Kappler, U. Staerz, J. White, P.C. Marrack, "Self-Tolerance Eliminates T Cells Specific for MIS-Modified Products of the Major Histocompatibility Complex," Nature, 332 (6159): pp. 35–40 (1988).
- J. White, et al. (P.C. Marrack), "The V(beta)-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletions in neonatal mice," Cell, v.56, n.1, pp. 27–35 (1989).
- 1986 - Appointed Investigator, Howard Hughes Medical Institute
- 1987 - Fellow (elected), Royal Society
- 1989 - Elected member, National Academy of Sciences
- 1990 - Royal Society Wellcome Foundation Prize
- 1993 - Cancer Research Institute William B. Coley Award
- 1993 - Paul Ehrlich and Ludwig Darmstaedter Prize
- 1994 - Louisa Gross Horwitz Prize (Columbia University)
- 2003 - Lifetime Achievement Award, American Association of Immunologists
- 2004 - L'Oreal UNESCO Women in Science Award
- 2005 - Pearl Meister Greengard Prize
- Rabbi Shai Shackner Prize (University of Jerusalem)
- 2015 - Wolf Prize in Medicine
- 2015 - Inducted into the National Women's Hall of Fame
- Rennie, J. (1992) Profile: Philippa Marrack and John Kappler – Keeping It In the Family, Scientific American 267(2), 43-44.
- Yount, Lisa (2007). "Marrack, Philippa". A to Z of Women in Science and Math (Rev. ed.). New York: Infobase Pub. p. 191. ISBN 978-1-4381-0795-0.
- "Philippa Marack To Be Honored for Lifetime Achievement in Immunology", May 4, 2003.
- AAI Award History
- Immunologist "Philippa Marrack to Receive Rockefeller University's Pearl Meister Greengard Prize", Nov. 2, 2005.
- Siegel-Itzkovich, Judy (January 29, 2015). "Wolf Prizes in the sciences and arts presented to nine North Americans". The Jerusalem Post. Retrieved 5 May 2016.
- Marisa Zeppieri-Caruana. "10 women honored at Hall of Fame induction". Democratandchronicle.com. Retrieved 2015-10-04.
- National Women's Hall of Fame. "Marrack, Philippa - National Women's Hall of Fame". womenofthehall.org. Retrieved 2017-02-13.
- HHMI Profile of work
- "Becoming a Scientist", Philippa Marrack, HHMI
- Christine Bahls, "Philippa Marrack", 'The Scientist v.18, n.6, p. 13 (2004).
- "Profile: Philippa Marrack", Nature Medicine, v.10, n.12.