Philippa Marrack

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Philippa Marrack
Philippa Marrack 1992 - National Jewish Health.jpg
Born (1945-06-28) 28 June 1945 (age 75)
Ewell, England
Other namesPippa Marrack
Alma materNew Hall, Cambridge (University of Cambridge) (M.A., Ph.D)
Known fordiscovery of T cell receptor, discovery of superantigens, T cells, autoimmune disease
Spouse(s)John W. Kappler
AwardsMember, National Academy of Sciences (1989)

Louisa Gross Horwitz Prize (1995)
Dickson Prize (1996)
Fellow, Royal Society (1997)
L'Oréal-UNESCO Award for Women in Science (2004)

National Women's Hall of Fame (2015)
Scientific career
InstitutionsUniversity of California, San Diego
University of Rochester
National Jewish Health
University of Colorado Denver
Doctoral advisorAlan Munro
WebsiteKM lab website

Philippa "Pippa" Marrack FRS (born 28 June 1945) is an English immunologist and academic, based in the United States, best known for her research into T cell development, T cell apoptosis and survival, adjuvants, autoimmune disease, and for identifying superantigens, the mechanism behind toxic shock syndrome.[1] She collaborates with her husband, John W. Kappler.[2]


Dr. Marrack was born in Ewell, England on 28 June 1945.[3][4] She completed both undergraduate (1967) and PhD (1970) work at New Hall, Cambridge. During her PhD, she worked at the MRC Laboratory of Molecular Biology with Alan Munro, where she began to study the differences between T cells and B cells.

She later did postdoctoral work with Richard Dutton at the University of California, San Diego.

Her first faculty position was with the University of Rochester, followed by the National Jewish Health, Denver, Colorado and the University of Colorado. She is a Howard Hughes Medical Institute investigator.[5]

She collaborates with her husband John W. Kappler. They met in 1971 as postdoctoral fellows at the University of California, San Diego.[6] The pair launched a joint lab at the University of Rochester. [7] In 1983 they discovered the T cell receptor, together with Ellis Reinherz and James Allison.

Marrack attributes her interest in immunology to having a genetic connection to her great uncle, the British pathologist John Marrack.[6][8]

Marrack plays the piano and is a blues guitarist.[6]

Professional activities[edit]

Dr. Marrack served as president of the American Association of Immunologists (AAI) from 2000 to 2001 and was a member of the AAI Council from 1995 to 2002.[5]

Significant papers[edit]

  • J.W. Kappler, M. Roehm, P. Marrack, "T cell tolerance by clonal elimination in the thymus," Cell, v.49, n.2, pp. 273–80 (1987).
  • P. Marrack and J. Kappler, "The Staphylococcal Enterotoxins and Their Relatives," Science, v.248 (4956), pp. 705–11 (1990).
  • J.W. Kappler, U. Staerz, J. White, P.C. Marrack, "Self-Tolerance Eliminates T Cells Specific for MIS-Modified Products of the Major Histocompatibility Complex," Nature, 332 (6159): pp. 35–40 (1988).
  • J. White, et al. (P.C. Marrack), "The V(beta)-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletions in neonatal mice," Cell, v.56, n.1, pp. 27–35 (1989).
  • J.W. Kappler, et al. "Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition." Journal of Experimental Medicine 153.5 (1981): 1198–1214.



  1. ^ Rennie, J. (1992) "Profile: Philippa Marrack and John Kappler – Keeping It In the Family", Scientific American 267(2), 43–44.
  2. ^ International who's who of women 2014. London: Europa Publications Limited. ISBN 9781857436945. OCLC 855705836.
  3. ^ Yount, Lisa (2007). "Marrack, Philippa". A to Z of Women in Science and Math (Rev. ed.). New York: Infobase Pub. p. 191. ISBN 978-1-4381-0795-0.
  4. ^ a b Marquis Who's Who, ed. (2016). "Marrack, Philippa Charlotte". Marquis Who's Who (33rd ed.). Marquis Who's Who LLC.
  5. ^ a b c d "Philippa Marrack, Ph.D." American Association of Immunologists. Retrieved 29 January 2020.
  6. ^ a b c Powell, Kendall (December 2004). "Profile: Philippa Marrack". Nature Medicine. 10 (12): 1270. doi:10.1038/nm1204-1270. PMID 15580239.
  7. ^ Powell, Kendall (1 December 2004). "Profile: Philippa Marrack". Nature Medicine. 10 (12): 1270–1270. doi:10.1038/nm1204-1270. ISSN 1546-170X.
  8. ^ Immunologists, The Amer Assn of (26 April 2013), Philippa Marrack, Ph.D. (AAI '74, president 2000–2001), retrieved 30 January 2020
  9. ^ Ward, Lauren (31 March 1992). "Immunologist Marrack to give Dyer Lecture". The NIH Record (XLIV(7)). National Institutes of Health. pp. 1–2. Retrieved 27 March 2020.
  10. ^ a b Allstetter, William (4 May 2003). "Philippa Marrack to Be Honored for Lifetime Achievement in Immunology". National Jewish Medical & Research Center. Retrieved 27 March 2020.
  11. ^ "Philippa Marrack". American Academy of Arts and Sciences. Retrieved 3 May 2019.
  12. ^ "M. D. Anderson Cancer Center - Current Research/Awards". Retrieved 24 November 2019.
  13. ^ "William B. Coley Award". Cancer Research Institute. Retrieved 27 March 2020.
  14. ^ "Announcement". Immunology. 78:3: 511. March 1993 – via EBSCO Academic Search Complete.
  15. ^ "Horwitz Prize Awardees". Columbia University Irving Medical Center. 20 June 2018. Retrieved 24 November 2019.
  16. ^ "Bonnie Bassler, PhD". Retrieved 24 November 2019.
  17. ^ "The Rabbi Shai Shaknai Award - מרכז לאוטנברג לאימונולוגיה וחקר הסרטן | Lautenberg Center for Immunology and Cancer research". מרכז לאוטנברג לאימונולוגיה וחקר הסרטן | Lautenberg Center for Immunology and Cancer research. Retrieved 24 November 2019.
  18. ^ "Dr Philippa Marrack | The Academy of Medical Sciences". Retrieved 24 November 2019.
  19. ^ "Philippa Marack To Be Honored for Lifetime Achievement in Immunology" Archived 7 February 2008 at the Wayback Machine, 4 May 2003.
  20. ^ "AAI Award History". Archived from the original on 15 November 2007. Retrieved 24 November 2007.
  21. ^ sean. "Past Honorees". Bonfils-Stanton Foundation. Retrieved 24 November 2019.
  22. ^ Immunologist "Philippa Marrack to Receive Rockefeller University's Pearl Meister Greengard Prize", 2 November 2005.
  23. ^ "Deutscher Immunologiepreis" (in German). Retrieved 24 November 2019.
  24. ^ "Member Directory - Philippa Marrack, Ph.D." National Academy of Medicine.
  25. ^ Colorado Women's Hall of Fame, Philippa Marrack, PhD
  26. ^ Siegel-Itzkovich, Judy (29 January 2015). "Wolf Prizes in the sciences and arts presented to nine North Americans". The Jerusalem Post. Retrieved 5 May 2016.
  27. ^ Marisa Zeppieri-Caruana. "10 women honored at Hall of Fame induction". Retrieved 4 October 2015.
  28. ^ National Women's Hall of Fame. "Marrack, Philippa – National Women's Hall of Fame". Retrieved 13 February 2017.
  29. ^ "Marrack, Philippa". National Women’s Hall of Fame. Retrieved 30 January 2020.
  30. ^ "Six leading scientists to receive prestigious Novartis Prizes for Immunology at 16th International Congress of Immunology". Novartis. Retrieved 24 November 2019.
  31. ^ "Researchers of Nobel class: Citation Laureates 2019". Web of Science Group. Retrieved 24 November 2019.

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