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TRAF6

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TRAF6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTRAF6, MGC:3310, RNF85, TNF receptor associated factor 6
External IDsOMIM: 602355; MGI: 108072; HomoloGene: 3395; GeneCards: TRAF6; OMA:TRAF6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

7189

22034

Ensembl

ENSG00000175104

ENSMUSG00000027164

UniProt

Q9Y4K3

P70196

RefSeq (mRNA)

NM_145803
NM_004620

NM_009424
NM_001303273

RefSeq (protein)

NP_004611
NP_665802

NP_001290202
NP_033450

Location (UCSC)Chr 11: 36.48 – 36.51 MbChr 2: 101.51 – 101.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TRAF6 is a TRAF human protein.

Function

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/TRANCE/RANKL and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported.[5]

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations

Interactions

TRAF6 has been shown to interact with:

Model organisms

Model organisms have been used in the study of TRAF6 function. A conditional knockout mouse line called Traf6tm2a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[44] Male and female animals underwent a standardized phenotypic screen[45] to determine the effects of deletion.[46][47][48][49] Additional screens performed: - In-depth immunological phenotyping[50]

References

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Further reading

  • Wajant H, Henkler F, Scheurich P (2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators". Cell. Signal. 13 (6): 389–400. doi:10.1016/S0898-6568(01)00160-7. PMID 11384837.
  • Bradley JR, Pober JS (2001). "Tumor necrosis factor receptor-associated factors (TRAFs)". Oncogene. 20 (44): 6482–91. doi:10.1038/sj.onc.1204788. PMID 11607847.
  • Tanaka S, Nakamura K, Takahasi N, Suda T (2006). "Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system". Immunol. Rev. 208: 30–49. doi:10.1111/j.0105-2896.2005.00327.x. PMID 16313339.
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