Bone morphogenetic protein 7: Difference between revisions

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{{PBB|geneid=655}}
{{protein

|Name=bone morphogenetic protein 7
⚫
'''Bone morphogenetic protein 7''' or '''BMP7''' (also known as '''osteogenic protein-1''' or '''OP-1''') is a [[protein]] that in humans is encoded by the ''BMP7'' [[gene]].<ref name="pmid1427904">{{cite journal | author = Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS | title = A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7 | journal = Genomics | volume = 14 | issue = 3 | pages = 759–62 | year = 1992 | month = November | pmid = 1427904 | doi = 10.1016/S0888-7543(05)80181-8 | url = }}</ref>
|caption=
|image=Noggin.png
|width=
|HGNCid=1074
|Symbol=BMP7
|AltSymbols=OP-1
|EntrezGene=655
|OMIM=112267
|RefSeq= NM_001719
|UniProt= P18075
|PDB=
|ECnumber=
|Chromosome=20
|Arm=q
|Band=13
|LocusSupplementaryData=
}}
⚫
'''Bone morphogenetic protein 7''' or '''BMP7''' (also known as '''Osteogenic Protein-1''' or '''OP-1''') is a human [[gene]].<ref name="pmid1427904">{{cite journal | author = Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS | title = A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7 | journal = Genomics | volume = 14 | issue = 3 | pages = 759–62 | year = 1992 | month = November | pmid = 1427904 | doi = 10.1016/S0888-7543(05)80181-8 | url = }}</ref>


==Function==
==Function==
Line 42: Line 25:


== References ==
== References ==
{{Reflist|2}}
{{Reflist|colwidth=30em}}

==Further reading==
{{refbegin|colwidth=30em}}
*{{cite journal |author=Xiao HQ, Shi W, Zhang Y, Liang YZ |title=[Effect of bone morphogenic protein 7 on nephrin expression and distribution in diabetic rat kidneys] |journal=Nan Fang Yi Ke Da Xue Xue Bao |volume=29 |issue= 4 |pages= 671-5 |year= 2009 |pmid= 19403392 |doi= }}
*{{cite journal |author=Murray LA, Hackett TL, Warner SM, ''et al.'' |title=BMP-7 does not protect against bleomycin-induced lung or skin fibrosis. |journal=PLoS ONE |volume=3 |issue= 12 |pages= e4039 |year= 2008 |pmid= 19112509 |doi= 10.1371/journal.pone.0004039 }}
*{{cite journal |author=Freedman BI, Bowden DW, Ziegler JT, ''et al.'' |title=Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study. |journal=J. Bone Miner. Res. |volume=24 |issue= 10 |pages= 1719-27 |year= 2009 |pmid= 19453255 |doi= 10.1359/jbmr.090501 }}
*{{cite journal |author=Garriock HA, Kraft JB, Shyn SI, ''et al.'' |title=A genomewide association study of citalopram response in major depressive disorder. |journal=Biol. Psychiatry |volume=67 |issue= 2 |pages= 133-8 |year= 2010 |pmid= 19846067 |doi= 10.1016/j.biopsych.2009.08.029 }}
*{{cite journal |author=Reddi AH |title=Bone morphogenetic proteins and skeletal development: the kidney-bone connection. |journal=Pediatr. Nephrol. |volume=14 |issue= 7 |pages= 598-601 |year= 2000 |pmid= 10912525 |doi= }}
*{{cite journal |author=Gautschi OP, Cadosch D, Zellweger R, ''et al.'' |title=Apoptosis induction and reduced proliferation in human osteoblasts by rhBMP-2, -4 and -7. |journal=J Musculoskelet Neuronal Interact |volume=9 |issue= 1 |pages= 53-60 |year= |pmid= 19240369 |doi= }}
*{{cite journal |author=Alarmo EL, Pärssinen J, Ketolainen JM, ''et al.'' |title=BMP7 influences proliferation, migration, and invasion of breast cancer cells. |journal=Cancer Lett. |volume=275 |issue= 1 |pages= 35-43 |year= 2009 |pmid= 18980801 |doi= 10.1016/j.canlet.2008.09.028 }}
*{{cite journal |author=Elshaier AM, Hakimiyan AA, Rappoport L, ''et al.'' |title=Effect of interleukin-1beta on osteogenic protein 1-induced signaling in adult human articular chondrocytes. |journal=Arthritis Rheum. |volume=60 |issue= 1 |pages= 143-54 |year= 2009 |pmid= 19116903 |doi= 10.1002/art.24151 }}
*{{cite journal |author=Yerges LM, Klei L, Cauley JA, ''et al.'' |title=High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. |journal=J. Bone Miner. Res. |volume=24 |issue= 12 |pages= 2039-49 |year= 2009 |pmid= 19453261 |doi= 10.1359/jbmr.090524 }}
*{{cite journal |author=Dudas PL, Argentieri RL, Farrell FX |title=BMP-7 fails to attenuate TGF-beta1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells. |journal=Nephrol. Dial. Transplant. |volume=24 |issue= 5 |pages= 1406-16 |year= 2009 |pmid= 19056781 |doi= 10.1093/ndt/gfn662 }}
*{{cite journal |author=Honsawek S, Chayanupatkul M, Tanavalee A, ''et al.'' |title=Relationship of plasma and synovial fluid BMP-7 with disease severity in knee osteoarthritis patients: a pilot study. |journal=Int Orthop |volume=33 |issue= 4 |pages= 1171-5 |year= 2009 |pmid= 19301001 |doi= 10.1007/s00264-009-0751-z }}
*{{cite journal |author=Sengle G, Ono RN, Lyons KM, ''et al.'' |title=A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. |journal=J. Mol. Biol. |volume=381 |issue= 4 |pages= 1025-39 |year= 2008 |pmid= 18621057 |doi= 10.1016/j.jmb.2008.06.074 }}
*{{cite journal |author=Mitu G, Hirschberg R |title=Bone morphogenetic protein-7 (BMP7) in chronic kidney disease. |journal=Front. Biosci. |volume=13 |issue= |pages= 4726-39 |year= 2008 |pmid= 18508541 |doi= }}
*{{cite journal |author=Brown A, Stock G, Patel AA, ''et al.'' |title=Osteogenic protein-1 : a review of its utility in spinal applications. |journal=BioDrugs |volume=20 |issue= 4 |pages= 243-51 |year= 2006 |pmid= 16831023 |doi= }}
*{{cite journal |author=Fajardo M, Liu CJ, Egol K |title=Levels of expression for BMP-7 and several BMP antagonists may play an integral role in a fracture nonunion: a pilot study. |journal=Clin. Orthop. Relat. Res. |volume=467 |issue= 12 |pages= 3071-8 |year= 2009 |pmid= 19597895 |doi= 10.1007/s11999-009-0981-9 }}
*{{cite journal |author=Giannoudis PV, Kanakaris NK, Dimitriou R, ''et al.'' |title=The synergistic effect of autograft and BMP-7 in the treatment of atrophic nonunions. |journal=Clin. Orthop. Relat. Res. |volume=467 |issue= 12 |pages= 3239-48 |year= 2009 |pmid= 19396502 |doi= 10.1007/s11999-009-0846-2 }}
*{{cite journal |author=Kalluri R, Neilson EG |title=Epithelial-mesenchymal transition and its implications for fibrosis. |journal=J. Clin. Invest. |volume=112 |issue= 12 |pages= 1776-84 |year= 2003 |pmid= 14679171 |doi= 10.1172/JCI20530 }}
*{{cite journal |author=Zhu L, Chuanchang D, Wei L, ''et al.'' |title=Enhanced healing of goat femur-defect using BMP7 gene-modified BMSCs and load-bearing tissue-engineered bone. |journal=J. Orthop. Res. |volume=28 |issue= 3 |pages= 412-8 |year= 2010 |pmid= 19725097 |doi= 10.1002/jor.20973 }}
*{{cite journal |author=Vieira AR, McHenry TG, Daack-Hirsch S, ''et al.'' |title=Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. |journal=Genet. Med. |volume=10 |issue= 9 |pages= 668-74 |year= 2008 |pmid= 18978678 |doi= 10.1097/GIM.0b013e3181833793 }}
*{{cite journal |author=Kron K, Pethe V, Briollais L, ''et al.'' |title=Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays. |journal=PLoS ONE |volume=4 |issue= 3 |pages= e4830 |year= 2009 |pmid= 19283074 |doi= 10.1371/journal.pone.0004830 }}
{{refend}}


==External links==
==External links==
Line 48: Line 55:




{{PDB Gallery|geneid=655}}
{{TGF beta signaling}}
{{TGF beta signaling}}
{{gene-20-stub}}
{{gene-20-stub}}

Revision as of 05:26, 16 March 2010

Template:PBB

Bone morphogenetic protein 7 or BMP7 (also known as osteogenic protein-1 or OP-1) is a protein that in humans is encoded by the BMP7 gene.[1]

Function

The protein encoded by this gene is a member of the TGF-β superfamily. Like other members of the bone morphogenetic protein family of proteins, it plays a key role in the transformation of mesenchymal cells into bone and cartilage. It is inhibited by noggin and a similar protein, chordin, which are expressed in the Spemann-Mangold Organizer. BMP7 may be involved in bone homeostasis. It is expressed in the brain, kidneys and bladder.[2]

BMP7 induces the phosphorylation of SMAD1 and SMAD5, which in turn induce transcription of numerous osteogenic genes.[3] It has been demonstrated that BMP7 treatment is sufficient to induce all of the genetic markers of osteoblast differentiation in many cell types.[2]

Role in vertebrate development

BMP7 has been discovered to be crucial in the determination of ventral-dorsal organization in zebrafish. BMP7 causes the expression of ventral phenotypes while its complete inhibition creates a dorsal phenotype. Moreover, BMP7 is eventually partially "turned off" in embryonic development in order to create the dorsal parts of the organism.[4]

In many early developmental experiments using zebrafish, scientists used caBMPR (constitutively active) and tBMP (truncated receptor) to determine the effect of BMP7 in embryogensis. They found that the constitutively active, which causes BMP to be expressed everywhere creates a ventralized phenotype, whereas truncated, dorsalized.

Therapeutic application

Human recombinant BMP7 has surgical uses and is marketed under the brand name OP1 (sold by Stryker). It can be used to aid in the fusion of vertebral bodies to prevent neurologic trauma.[5] Also in the treatment of tibial non-union, frequently in cases where a bone graft has failed.[6]

BMP7 also has the potential for treatment of chronic kidney disease.[7][8]

BMP7 administration has been proposed as a possible treatment for human infertility due to poor response to FSH treatment.[9]

Promotion of brown fat

It was discovered that mice injected with BMP7 increased their production of "good" brown fat cells, while keeping their levels of the normal white fat cells constant. A BMP7 therapy for obesity in humans may be developed as a result.[10][11]

References

  1. ^ Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics. 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  2. ^ a b Chen D, Zhao M, Mundy GR (2004). "Bone morphogenetic proteins". Growth Factors. 22 (4): 233–41. doi:10.1080/08977190412331279890. PMID 15621726. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  3. ^ Itoh F, Asao H, Sugamura K, Heldin CH, ten Dijke P, Itoh S (2001). "Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads". Embo J. 20 (15): 4132–42. doi:10.1093/emboj/20.15.4132. PMC 149146. PMID 11483516. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  4. ^ Myers DC, Sepich DS, Solnica-Krezel L (2002). "Bmp activity gradient regulates convergent extension during zebrafish gastrulation". Dev. Biol. 243 (1): 81–98. doi:10.1006/dbio.2001.0523. PMID 11846479. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  5. ^ Vaccaro AR, Whang PG, Patel T, Phillips FM, Anderson DG, Albert TJ, Hilibrand AS, Brower RS, Kurd MF, Appannagari A, Patel M, Fischgrund JS (2008). "The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft for posterolateral lumbar arthrodesis: minimum 4-year follow-up of a pilot study". Spine J. 8 (3): 457–65. doi:10.1016/j.spinee.2007.03.012. PMID 17588821.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  6. ^ Zimmermann G, Müller U, Löffler C, Wentzensen A, Moghaddam A (2007). "[Therapeutic outcome in tibial pseudarthrosis: bone morphogenetic protein 7 (BMP-7) versus autologous bone grafting for tibial fractures]". Unfallchirurg (in German). 110 (11): 931–8. doi:10.1007/s00113-007-1347-y. PMID 17989951. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  7. ^ Gould SE, Day M, Jones SS, Dorai H (2002). "BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells". Kidney Int. 61 (1): 51–60. doi:10.1046/j.1523-1755.2002.00103.x. PMID 11786084. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  8. ^ González EA, Lund RJ, Martin KJ, McCartney JE, Tondravi MM, Sampath TK, Hruska KA (2002). "Treatment of a murine model of high-turnover renal osteodystrophy by exogenous BMP-7". Kidney Int. 61 (4): 1322–31. doi:10.1046/j.1523-1755.2002.00258.x. PMID 11918739. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  9. ^ Shi J, Yoshino O, Osuga Y, Nishii O, Yano T, Taketani Y (2010). "Bone morphogenetic protein 7 (BMP-7) increases the expression of follicle-stimulating hormone (FSH) receptor in human granulosa cells". Fertil. Steril. 93 (4): 1273–9. doi:10.1016/j.fertnstert.2008.11.014. PMID 19108831. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  10. ^ Jha A (2008-08-21). "Obesity: Scientists identify protein that promotes fat-burning". Science. guardian.co.uk. Retrieved 2008-09-03. {{cite web}}: Cite has empty unknown parameter: |coauthors= (help)
  11. ^ Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR (2008). "New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure". Nature. 454 (7207): 1000–4. doi:10.1038/nature07221. PMID 18719589. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

Further reading

  • Xiao HQ, Shi W, Zhang Y, Liang YZ (2009). "[Effect of bone morphogenic protein 7 on nephrin expression and distribution in diabetic rat kidneys]". Nan Fang Yi Ke Da Xue Xue Bao. 29 (4): 671–5. PMID 19403392.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Murray LA, Hackett TL, Warner SM; et al. (2008). "BMP-7 does not protect against bleomycin-induced lung or skin fibrosis". PLoS ONE. 3 (12): e4039. doi:10.1371/journal.pone.0004039. PMID 19112509. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  • Freedman BI, Bowden DW, Ziegler JT; et al. (2009). "Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study". J. Bone Miner. Res. 24 (10): 1719–27. doi:10.1359/jbmr.090501. PMID 19453255. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Garriock HA, Kraft JB, Shyn SI; et al. (2010). "A genomewide association study of citalopram response in major depressive disorder". Biol. Psychiatry. 67 (2): 133–8. doi:10.1016/j.biopsych.2009.08.029. PMID 19846067. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Reddi AH (2000). "Bone morphogenetic proteins and skeletal development: the kidney-bone connection". Pediatr. Nephrol. 14 (7): 598–601. PMID 10912525.
  • Gautschi OP, Cadosch D, Zellweger R; et al. "Apoptosis induction and reduced proliferation in human osteoblasts by rhBMP-2, -4 and -7". J Musculoskelet Neuronal Interact. 9 (1): 53–60. PMID 19240369. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Alarmo EL, Pärssinen J, Ketolainen JM; et al. (2009). "BMP7 influences proliferation, migration, and invasion of breast cancer cells". Cancer Lett. 275 (1): 35–43. doi:10.1016/j.canlet.2008.09.028. PMID 18980801. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Elshaier AM, Hakimiyan AA, Rappoport L; et al. (2009). "Effect of interleukin-1beta on osteogenic protein 1-induced signaling in adult human articular chondrocytes". Arthritis Rheum. 60 (1): 143–54. doi:10.1002/art.24151. PMID 19116903. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Yerges LM, Klei L, Cauley JA; et al. (2009). "High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men". J. Bone Miner. Res. 24 (12): 2039–49. doi:10.1359/jbmr.090524. PMID 19453261. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Dudas PL, Argentieri RL, Farrell FX (2009). "BMP-7 fails to attenuate TGF-beta1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells". Nephrol. Dial. Transplant. 24 (5): 1406–16. doi:10.1093/ndt/gfn662. PMID 19056781.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Honsawek S, Chayanupatkul M, Tanavalee A; et al. (2009). "Relationship of plasma and synovial fluid BMP-7 with disease severity in knee osteoarthritis patients: a pilot study". Int Orthop. 33 (4): 1171–5. doi:10.1007/s00264-009-0751-z. PMID 19301001. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Sengle G, Ono RN, Lyons KM; et al. (2008). "A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7". J. Mol. Biol. 381 (4): 1025–39. doi:10.1016/j.jmb.2008.06.074. PMID 18621057. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Mitu G, Hirschberg R (2008). "Bone morphogenetic protein-7 (BMP7) in chronic kidney disease". Front. Biosci. 13: 4726–39. PMID 18508541.
  • Brown A, Stock G, Patel AA; et al. (2006). "Osteogenic protein-1 : a review of its utility in spinal applications". BioDrugs. 20 (4): 243–51. PMID 16831023. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Fajardo M, Liu CJ, Egol K (2009). "Levels of expression for BMP-7 and several BMP antagonists may play an integral role in a fracture nonunion: a pilot study". Clin. Orthop. Relat. Res. 467 (12): 3071–8. doi:10.1007/s11999-009-0981-9. PMID 19597895.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Giannoudis PV, Kanakaris NK, Dimitriou R; et al. (2009). "The synergistic effect of autograft and BMP-7 in the treatment of atrophic nonunions". Clin. Orthop. Relat. Res. 467 (12): 3239–48. doi:10.1007/s11999-009-0846-2. PMID 19396502. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Kalluri R, Neilson EG (2003). "Epithelial-mesenchymal transition and its implications for fibrosis". J. Clin. Invest. 112 (12): 1776–84. doi:10.1172/JCI20530. PMID 14679171.
  • Zhu L, Chuanchang D, Wei L; et al. (2010). "Enhanced healing of goat femur-defect using BMP7 gene-modified BMSCs and load-bearing tissue-engineered bone". J. Orthop. Res. 28 (3): 412–8. doi:10.1002/jor.20973. PMID 19725097. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Vieira AR, McHenry TG, Daack-Hirsch S; et al. (2008). "Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts". Genet. Med. 10 (9): 668–74. doi:10.1097/GIM.0b013e3181833793. PMID 18978678. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Kron K, Pethe V, Briollais L; et al. (2009). "Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays". PLoS ONE. 4 (3): e4830. doi:10.1371/journal.pone.0004830. PMID 19283074. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)

External links


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