Fenspiride: Difference between revisions
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| IUPAC_name = 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one |
| IUPAC_name = 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one |
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| image = Fenspiride.svg |
| image = Fenspiride.svg |
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| width = 200 |
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| image2 = Fenspiride ball-and-stick animation.gif |
| image2 = Fenspiride ball-and-stick animation.gif |
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<!--Clinical data--> |
<!--Clinical data--> |
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| tradename = |
| tradename = Eurespal, Pneumorel |
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| Drugs.com = {{drugs.com|international|fenspiride}} |
| Drugs.com = {{drugs.com|international|fenspiride}} |
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| pregnancy_category = |
| pregnancy_category = |
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| legal_status = |
| legal_status = Rx-only |
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| routes_of_administration = |
| routes_of_administration = Oral |
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<!--Pharmacokinetic data--> |
<!--Pharmacokinetic data--> |
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| bioavailability = 90%<ref>{{cite journal|last=Montes|first=B|coauthors=Catalan, M; Roces, A; Jeanniot, JP; Honorato, JM|title=Single dose pharmacokinetics of fenspiride hydrochloride: phase I clinical trial.|journal=European journal of clinical pharmacology|date=1993|volume=45|issue=2|pages=169–72|pmid=7901024}}</ref> |
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| bioavailability = |
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| metabolism = |
| metabolism = |
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| elimination_half-life = |
| elimination_half-life = 14–16 hours |
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| excretion = |
| excretion = Urine (90%), feces (~10%) |
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<!--Identifiers--> |
<!--Identifiers--> |
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'''Fenspiride''' ([[International Nonproprietary Name|INN]], brand |
'''Fenspiride''' ([[International Nonproprietary Name|INN]], brand names '''Eurespal''', '''Pneumorel''' and others) is an oxazolidinone [[spiro compound]] used as a drug in the treatment of certain respiratory diseases.<ref>{{cite journal |title = Efficacy and tolerance of fenspiride in adult patients with acute respiratory tract infections |author = Płusa T, Nawacka D |journal = Pol Merkur Lekarski |year = 1998 Dec |volume =5 |pages = 368–71 |pmid=10101527 |issue=30}}</ref> In Russia it is approved for the treatment of acute and chronic inflammatory diseases of ENT organs and the respiratory tract (like rhinopharyngitis, laryngitis, tracheobronchitis, otitis and sinusitis), as well as for maintenance treatment of [[asthma]].<ref name=PI>{{cite web|title=Эреспал<sup>®</sup> (Eurespal<sup>®</sup>) Prescribing Information. VIDAL Drug Compendium|url=http://www.vidal.ru/poisk_preparatov/eurespal~34706.htm|accessdate=6 February 2014|language=Russian}}</ref> |
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== References == |
== References == |
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[[Category:Oxazolidinones]] |
[[Category:Oxazolidinones]] |
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[[Category:Spiro compounds]] |
[[Category:Spiro compounds]] |
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{{respiratory-system-drug-stub}} |
{{respiratory-system-drug-stub}} |
Revision as of 16:00, 6 February 2014
Clinical data | |
---|---|
Trade names | Eurespal, Pneumorel |
AHFS/Drugs.com | International Drug Names |
Routes of administration | Oral |
ATC code | |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Bioavailability | 90%[1] |
Elimination half-life | 14–16 hours |
Excretion | Urine (90%), feces (~10%) |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
UNII | |
KEGG | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.023.411 |
Chemical and physical data | |
Formula | C15H20N2O2 |
Molar mass | 260.331 g/mol g·mol−1 |
(what is this?) (verify) |
Fenspiride (INN, brand names Eurespal, Pneumorel and others) is an oxazolidinone spiro compound used as a drug in the treatment of certain respiratory diseases.[2] In Russia it is approved for the treatment of acute and chronic inflammatory diseases of ENT organs and the respiratory tract (like rhinopharyngitis, laryngitis, tracheobronchitis, otitis and sinusitis), as well as for maintenance treatment of asthma.[3]
References
- ^ Montes, B (1993). "Single dose pharmacokinetics of fenspiride hydrochloride: phase I clinical trial". European journal of clinical pharmacology. 45 (2): 169–72. PMID 7901024.
{{cite journal}}
: Unknown parameter|coauthors=
ignored (|author=
suggested) (help) - ^ Płusa T, Nawacka D (1998 Dec). "Efficacy and tolerance of fenspiride in adult patients with acute respiratory tract infections". Pol Merkur Lekarski. 5 (30): 368–71. PMID 10101527.
{{cite journal}}
: Check date values in:|year=
(help) - ^ "Эреспал® (Eurespal®) Prescribing Information. VIDAL Drug Compendium" (in Russian). Retrieved 6 February 2014.