Isamoltane

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Isamoltane
Isamoltane.png
Systematic (IUPAC) name
1-(propan-2-ylamino)-3-(2-pyrrol-1-ylphenoxy)propan-2-ol
Clinical data
Legal status ?
Identifiers
CAS number 99740-06-4
ATC code None
PubChem CID 127403
ChemSpider 113051
Chemical data
Formula C16H22N2O2 
Mol. mass 274.357 g/mol

Isamoltane (CGP-361A) is a drug used in scientific research. It acts as an antagonist at the β-adrenergic, 5-HT1A, and 5-HT1B receptors. It has about five times the potency for the 5-HT1B receptor (21 nmol/l) over the 5-HT1A receptor (112 nmol/l).[1] It has anxiolytic effects in rodents.[2]

References[edit]

  1. ^ Rényi L, Larsson LG, Berg S, Svensson BE, Thorell G, Ross SB. (1991). "Biochemical and behavioural effects of isamoltane, a beta-adrenoceptor antagonist with affinity for the 5-HT1B receptor of rat brain.". Naunyn Schmiedebergs Arch Pharmacol. 343 (1): 1–6. doi:10.1007/bf00180669. PMID 1674359. 
  2. ^ Waldmeier PC, Williams M, Baumann PA, Bischoff S, Sills MA, Neale RF. (1988). "Interactions of isamoltane (CGP 361A), an anxiolytic phenoxypropanolamine derivative, with 5-HT1 receptor subtypes in the rat brain.". Naunyn Schmiedebergs Arch Pharmacol. 337 (6): 609–620. doi:10.1007/bf00175785. PMID 2905765.