A-349,821

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A-349,821
A-349821.png
Systematic (IUPAC) name
(4'-[3-(2R,5R-dimethylpyrrolidin-1-yl)propoxy]biphenyl-4-yl)morpholin-4-ylmethanone
Clinical data
Legal status ?
Identifiers
ATC code ?
PubChem CID 9954017
IUPHAR ligand 1217
ChemSpider 8129627 YesY
ChEMBL CHEMBL179702 YesY
Chemical data
Formula C26H34N2O3 
Mol. mass 422.558
 YesY (what is this?)  (verify)

A-349,821 is a potent and selective histamine H3 receptor antagonist[1] (or possibly an inverse agonist).[2] It has nootropic effects in animal studies,[3] although there do not appear to be any plans for clinical development at present and it is currently only used in laboratory research.

See also[edit]

H3 receptor antagonist

References[edit]

  1. ^ Faghih, R; Dwight, W; Pan, JB; Fox, GB; Krueger, KM; Esbenshade, TA; McVey, JM; Marsh, K; Bennani, YL; Hancock, AA (2003). "Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists". Bioorganic & Medicinal Chemistry Letters 13 (7): 1325–8. doi:10.1016/S0960-894X(03)00118-5. PMID 12657274. 
  2. ^ Witte, DG; Yao, BB; Miller, TR; Carr, TL; Cassar, S; Sharma, R; Faghih, R; Surber, BW; Esbenshade, TA; Hancock, AA; Krueger, KM (2006). "Detection of multiple H3 receptor affinity states utilizing 3HA-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand". British Journal of Pharmacology 148 (5): 657–70. doi:10.1038/sj.bjp.0706752. PMC 1751875. PMID 16715122. 
  3. ^ Esbenshade, T. A.; Fox, G. B.; Krueger, K. M.; Baranowski, J. L.; Miller, T. R.; Kang, C. H.; Denny, L. I.; Witte, D. G.; Yao, B. B.; Pan, J. B.; Faghih, R.; Bennani, Y. L.; Williams, M.; Hancock, A. A. (2004). "Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist". Biochemical Pharmacology 68 (5): 933–945. doi:10.1016/j.bcp.2004.05.048. PMID 15294456.  edit