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John Cornforth

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Sir
John Cornforth
AC CBE FRS FAA
Cornforth in 1975
Born
John Warcup Cornforth Jr.

(1917-09-07)7 September 1917
Sydney, New South Wales, Australia
Died8 December 2013(2013-12-08) (aged 96)
Sussex, England
NationalityAustralian
CitizenshipAustralian
British
Alma mater
Known forStereochemistry of enzyme-catalysed reactions
Cholesterol total synthesis
Cornforth reagent
Cornforth rearrangement
SpouseRita Harradence
Awards
Scientific career
FieldsOrganic chemistry
Institutions
ThesisSynthesis of analogues of steroid hormones (1941)
Doctoral advisorRobert Robinson
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Sir John Warcup Cornforth Jr.,[3] AC, CBE, FRS, FAA (7 September 1917 – 8 December 2013) was an Australian–British chemist who won the Nobel Prize in Chemistry in 1975 for his work on the stereochemistry of enzyme-catalysed reactions,[4][5] becoming the only Nobel laureate born in New South Wales.[2][6][7]

Cornforth investigated enzymes that catalyse changes in organic compounds, the substrates, by taking the place of hydrogen atoms in a substrate's chains and rings. In his syntheses and descriptions of the structure of various terpenes, olefins, and steroids, Cornforth determined specifically which cluster of hydrogen atoms in a substrate were replaced by an enzyme to effect a given change in the substrate, allowing him to detail the biosynthesis of cholesterol.[8] For this work, he won a share of the Nobel Prize in Chemistry in 1975, alongside co-recipient Vladimir Prelog, and was knighted in 1977.[9]

Early life and family

Born in Sydney, Cornforth was the son and the second of four children of English-born, Oxford-educated schoolmaster and teacher John Warcup Cornforth and Hilda Eipper (1887–1969), a granddaughter of pioneering missionary and Presbyterian minister Christopher Eipper. Before her marriage, Eipper had been a maternity nurse.[3][10]

Cornforth was raised in Sydney as well as Armidale, in the north of New South Wales,[11] where he undertook primary school education.[10]

At about 10 years old,[12] Cornforth had noted signs of deafness, which led to a diagnosis of otosclerosis, a disease of the middle ear which causes progressive hearing loss. This left him completely deaf by the age of 20 but also fatefully influenced his career direction away from law, his original intended field of study, and towards chemistry.[13][14] In an interview with Sir Harry Kroto for the Vega Science Trust, Cornforth explained:

I had to find something in which the loss of hearing would not be too severe a handicap...I chose chemistry...The most liberating thing was the realization that the literature wasn't entirely correct. It gave me quite a shock at first, and then a thrill. Because I can set this right! And always, and ever since, I've relied upon the primary literature exclusively.[15]

Education

Cornforth was educated at Sydney Boys' High School, where he excelled academically, passed tests in English, mathematics, science, French, Greek, and Latin,[16] and was inspired by his chemistry teacher, Leonard ("Len") Basser,[17][18] to change his career directions from law to chemistry.[12][19] Cornforth graduated as the dux of the class of 1933 at Sydney Boys' High School, at the age of 16.[20]

In 1934, Cornforth matriculated and studied at the University of Sydney,[20][21] where he studied organic chemistry at the University of Sydney's School of Chemistry and from which he graduated with a Bachelor of Science with First-Class Honours and the University Medal in 1937.[9][22] During his studies, his hearing became progressively worse, thus making listening to lectures difficult.[citation needed] At the time, he could not use hearing aids as the sound became distorted, and he did not significantly use lip reading.[citation needed]

While studying at the University of Sydney, Cornforth met his future wife, fellow chemist and scientific collaborator, Rita Harradence.[23][24] Harradence was a graduate of St George Girls High School[23][24] and a distinguished academic achiever[10][25][26] who had topped the state in Chemistry in the New South Wales Leaving Certificate Examination.[27] Harradence graduated with a Bachelor of Science with First-Class Honours and the University Medal in Organic Chemistry in 1936, a year ahead of Cornforth.[28] Harradence also graduated with a MSc in 1937,[29] writing a master's thesis titled "Attempts to synthesise the pyridine analogue of vitamin B1".[30]

In 1939, Cornforth and Harradence, independently of each other, each won one of two Science Research Scholarships (the 1851 Research Fellowship) from the Royal Commission for the Exhibition of 1851,[31] tenable overseas for two years.[28] At the University of Oxford, Harradence was a member of Somerville College while Cornforth was at St. Catherine's College[32] and they worked with Sir Robert Robinson, with whom they collaborated for 14 years.[10] During his time at Oxford, Cornforth found working for and with Robinson stimulating, and the two often deliberated to no end until one had a cogent case against the other's counterargument.[33] In 1941, Cornforth and Harradence both graduated with a D.Phil. in Organic Chemistry.[34][35] At the time, there were no institutions or facilities at which a PhD in chemistry could be done in Australia.[36]

Career

After his arrival at Oxford and during World War II, Cornforth significantly influenced the work on penicillin, particularly in purifying and concentrating it. Penicillin is usually very unstable in its crude form; as a consequence of this, researchers at the time were building upon Howard Florey's work on the drug. In 1940, Cornforth and other chemists measured the yield of penicillin in arbitrary units to understand the conditions that favoured penicillin production and activity, and he contributed to the writing of The Chemistry of Penicillin.[37]

In 1946, the Cornforths, who had by now married, left Oxford and joined the Medical Research Council (MRC), working at the National Institute for Medical Research (NIMR), where they continued on earlier work in synthesising sterols, including cholesterol. The Cornforths' collaboration with Robinson continued and flourished. In 1951, they completed, simultaneously with Robert Burns Woodward[citation needed], the first total synthesis of the non-aromatic steroids. At the NIMR, Cornforth collaborated with numerous biological scientists, including George Popják,[38] with whom he shared an interest in cholesterol. Together, they received the Davy Medal in 1968 in recognition of their distinguished joint work on the elucidation of the biosynthetic pathway to polyisoprenoids and steroids.

While working at the MRC, Cornforth was appointed a professor at the University of Warwick and was employed there from 1965 to 1971.[39]

In 1975, Cornforth was awarded a share of the Nobel Prize in Chemistry, alongside Vladimir Prelog. In his acceptance speech, Cornforth said:

Throughout my scientific career my wife has been my most constant collaborator. Her experimental skill made major contributions to the work; she has eased for me beyond measure the difficulties of communication that accompany deafness; her encouragement and fortitude have been my strongest support.[40]

Also in 1975, he moved to the University of Sussex in Brighton as a Royal Society Research Professor.[11][41] Cornforth remained there as a professor and was active in research until his death.[42][43]

Personal life

In 1941, the year in which they graduated from the University of Oxford, Cornforth married Rita Harriet Harradence (b. 1915),[5][23][44] with whom he had one son, John, and two daughters, Brenda and Philippa.[3][45] Cornforth had met Harradence after she had broken a Claisen flask in their second year at the University of Sydney; Cornforth, with his expertise of glassblowing and the use of a blowpipe, mended the break.[46] Rita Cornforth died on 6 November 2012,[47] at home with her family around her,[48] following a long illness.[49]

On an important author or paper that was integral to his success, Cornforth stated that he was particularly impressed by the works of German chemist Hermann Emil Fischer.[46]

Cornforth died in Sussex on 8 December 2013.[45][50][51][52] at the age of 96.[53] Cornforth is survived by his three children and four grandchildren.[54] He was a sceptic and an atheist.[55]

Honours and awards

Cornforth was named the Australian of the Year in 1975,[56] jointly with Maj. Gen. Alan Stretton.[57] In 1977, Cornforth was recognised by his alma mater, the University of Sydney, with the award of an honorary Doctor of Science.[58][59] Cornforth's other awards and recognitions follow:

Cornforth's certificate of election for the Royal Society reads:

Distinguished as an Organic Chemist of outstanding originality and exceptional experimental skill, particularly in microchemical manipulation. He was the first to attribute the correct constitution to penicillamine and to synthesise the amino-acid. After making significant contributions to the synthesis of penicillin he notably developed the chemistry of the oxazole group and made oxazole itself for the first time.

The important share he took in the total synthesis of androgenic hormones and other steroids is gratefully recognised by all his collaborators in the investigation.

Miscellaneous work on natural products and chemotherapy equally displays individual thought, invention, and superlative technical accomplishment.[1]

Cornforth was the focus of a skit on an episode of Comedy Inc., whereby a fictional Who Wants to Be A Millionaire? contestant (played by Genevieve Morris) is asked "Which Australian scientist won the Nobel Prize for Chemistry in 1975?" for the million-dollar question. As it happens, the contestant gleefully claims they are second cousins with Cornforth (despite being nearly 50 years his junior) and knows Cornforth is the answer, confidently rattling off a bunch of highly specific and esoteric facts about Cornforth's life and achievements, all the while the host (a satirical portrayal of Eddie McGuire) stubbornly and continuously stalls her for dramatic effect, asking her for several minutes if she'd like to think about it more to an absurd degree.[64]

On September 7, 2017, Google celebrated his 100th birthday with a Google Doodle.[65]

References

  1. ^ a b c "Cornforth, Sir, John Warcup: Library and Archive Catalogue". London: The Royal Society. Archived from the original on 27 March 2014.
  2. ^ a b c Battersby, Sir Alan R.; Young, Douglas W. (2015). "Sir John Warcup Cornforth AC CBE. 7 September 1917 – 8 December 2013". Biographical Memoirs of Fellows of the Royal Society. 62: 19–57. doi:10.1098/rsbm.2015.0016. ISSN 0080-4606.
  3. ^ a b c "John Cornforth". NNDB. Retrieved 1 July 2017.
  4. ^ Hanson, Jim (2014). "John Cornforth (1917–2013) Nobel-prizewinning chemist who tracked how enzymes build cholesterol". Nature. 506 (7486): 35. Bibcode:2014Natur.506...35H. doi:10.1038/506035a. PMID 24499912.
  5. ^ a b "Sir John Cornforth". Encyclopædia Britannica. 2012.
  6. ^ Dean, Chris. "John 'Kappa' Cornforth". Vega Science Trust. Retrieved 1 July 2017.
  7. ^ Chang, Kenneth (19 December 2013). "John W. Cornforth, 96, Nobel-Winning Chemist, Dies". The New York Times. Retrieved 1 July 2017.
  8. ^ Deaf Scientist Corner – John Warcup Cornforth, Texas Woman's University
  9. ^ a b "John Cornforth". Royal Institution of Australia. Archived from the original on 14 January 2014.
  10. ^ a b c d "Sir John Cornforth (1917–2013)". University of Sydney, School of Chemistry. Archived from the original on 7 December 2013. Retrieved 1 July 2017.
  11. ^ a b "John Cornforth – Biographical". Nobelprize.org. 2014. Retrieved 1 July 2017.
  12. ^ a b "How the Cornforths started out in chemistry". University of Sydney, School of Chemistry. Retrieved 1 July 2017.
  13. ^ John Cornforth Archived 15 February 2011 at the Wayback Machine, biotechnology-innovation.com.au
  14. ^ II, Thomas H. Maugh (28 December 2013). "John Cornforth dies at 96; Nobel Prize-winning chemist". Los Angeles Times. Retrieved 11 April 2023.
  15. ^ Cornforth, John (January 2002). "Sir John Cornforth: An Interview by Bob Thomas and Sir Harry Kroto". Retrieved 11 April 2023.
  16. ^ Sperans (18 January 1932). "Bright students: intermediate stage". The Sydney Morning Herald. p. 8.
  17. ^ Doherty, P. C. (2006). The Beginner's Guide to Winning the Nobel Prize: A Life in Science. Columbia University Press. p. 89. ISBN 9780231511261.
  18. ^ "Patrons". Sydney High School Old Boys Union. Archived from the original on 21 March 2019. Retrieved 17 July 2012.
  19. ^ Cribb, J. (6 September 2006). "Master of the molecules". Cosmos. Archived from the original on 5 September 2012.
  20. ^ a b Eckert, Jim. "Jim Eckert writes about the Cornforth". University of Sydney, School of Chemistry. Archived from the original on 14 January 2014.
  21. ^ "John Cornforth: Brilliant chemist was profoundly deaf". The Sydney Morning Herald. 14 December 2013.
  22. ^ "Nobel Laureates – Chemistry". The University of Sydney. Archived from the original on 13 February 2010. Retrieved 3 December 2009.
  23. ^ a b c "Notable Old Girls – History of St George Girls High School – Our School". St George Girls High School. Archived from the original on 2 July 2012.
  24. ^ a b "History – Chemistry – The Cornforths". The University of Sydney. Archived from the original on 3 December 2013. Retrieved 17 July 2012.
  25. ^ "St. George Girls' High School". The Sydney Morning Herald. 15 December 1931.
  26. ^ "Bursaries: tenable at university". The Sydney Morning Herald. 17 February 1933.
  27. ^ "Biographical memoirs: Arthur Birch". Australian Academy of Science. Archived from the original on 21 March 2014.
  28. ^ a b "Scientific research". The Sydney Morning Herald. 1 July 1939.
  29. ^ White, J.W. (5 February 1996). "Rita Cornforth Fellowships". Research School of Chemistry, ANU. Archived from the original on 26 October 2009. Retrieved 2 December 2013.
  30. ^ Harradence, Rita Harriet (1938). Attempts to synthesise the pyridine analogue of vitamin B1 (M.Sc.). University of Sydney. Retrieved 1 July 2017 – via National Library of Australia.
  31. ^ "Award History". 1851 Research Fellowship. Archived from the original on 3 December 2013. Retrieved 2 December 2013.
  32. ^ "Sir John Cornforth 1917–2013". St Catherine's College, Oxford. Archived from the original on 14 October 2018. Retrieved 13 January 2014.
  33. ^ Hargittai, I.; Hargittai, M. (2000). Candid Science: Conversations with Famous Chemists. London, UK: Imperial College Press. ISBN 1860942288.
  34. ^ Cornforth, John Warcup (1941). Synthesis of analogues of steroid hormones (DPhil thesis). University of Oxford.
  35. ^ "Winter 2009 Alumni Newsletter" (PDF). The University of Sydney United Kingdom Alumni Association. Winter 2009.
  36. ^ "Obituary: Professor Sir John Cornforth". University of Sussex. 20 December 2013.
  37. ^ Clarke, H. T.; Johnson, J. R.; Robinson, R., eds. (1949). The Chemistry of Penicillin. New Jersey: Princeton University Press.
  38. ^ "Professor George Joseph Popjak, MD, DSc, FRS: May 5, 1914 – December 30, 1998". Arteriosclerosis, Thrombosis, and Vascular Biology. 19 (4): 830. 1999. doi:10.1161/01.ATV.19.4.830.
  39. ^ "Sir John Cornforth Obituary". The Independent. 9 January 2014.
  40. ^ "Rita Cornforth Fellowships". Australian National University. Archived from the original on 26 October 2009. Retrieved 27 May 2016.
  41. ^ Daintith, John; Gjertsen, Derek (1999). A Dictionary of Scientists (Abridged and updated ed.). Oxford, UK: Oxford University Press. p. 112. ISBN 0192800868.
  42. ^ "Sir John Cornforth: School of Life Sciences". University of Sussex. Retrieved 1 July 2017.
  43. ^ "Sir John Warcup Cornforth". The University of Sydney.
  44. ^ "Cornforth, Rita (1915–2012)". Encyclopedia of Australian Science.
  45. ^ a b "Sir John Cornforth". The Daily Telegraph. 9 January 2014.
  46. ^ a b "Kappa interviewed by Bob Thomas". The Vega Science Trust.
  47. ^ "Obituary: Dr Lady Rita Cornforth". University of Sydney. Archived from the original on 21 March 2014.
  48. ^ "Lady Rita Harriet Cornforth: Obituary". Announce.Jpress. Archived from the original on 21 March 2014. Retrieved 21 March 2014.
  49. ^ "Newsletter No. 29". The Suss-Ex Club. 2014.
  50. ^ "Sir John Warcup Cornforth: Obituary". Sussex Express. 13 December 2013. Archived from the original on 18 December 2015. Retrieved 21 March 2014.
  51. ^ Chang, Kenneth (20 December 2013). "John W. Cornforth, 96, Nobel-Winning Chemist, Dies". The New York Times.
  52. ^ Young, Douglas (13 January 2014). "Sir John Cornforth obituary". The Guardian.
  53. ^ "Obituary: Professor Sir John Cornforth". University of Sussex. Archived from the original on 19 December 2013. Retrieved 18 December 2013.
  54. ^ "John Warcup Cornforth, the only Australian to win Nobel Prize for chemistry, dies age 95". ABC Radio Australia. 21 May 2023.
  55. ^ Kroto, Harold (2015). "Sir John Cornforth ('Kappa'): Some Personal Recollections". Australian Journal of Chemistry. 68 (4): 697–698. doi:10.1071/CH14601.
  56. ^ Australian of the Year Awards – John Cornforth Archived 31 March 2010 at the Wayback Machine, Australian of the Year
  57. ^ Lewis, Wendy (2010). Australians of the Year. Pier 9 Press. ISBN 978-1-74196-809-5.
  58. ^ "Prominent Alumni". University of Sydney.
  59. ^ Andrews, Kirsten (17 December 2013). "Mourning the loss of Australia's only Nobel prize winner in Chemistry, Sir John Warcup Cornforth". University of Sydney.
  60. ^ a b "Sir John Warcup Cornforth". University of Sydney, Faculty of Science. Retrieved 14 December 2013.
  61. ^ "Sir J.W. (John) Cornforth jr. (1917–2013)". Royal Netherlands Academy of Arts and Sciences. Retrieved 18 March 2016.
  62. ^ "Cornforth, John Warcup (AC)". It's an Honour: AC. Retrieved 14 December 2013.
  63. ^ "Centenary Medal". It's an Honour. Archived from the original on 22 February 2019. Retrieved 14 December 2013.
  64. ^ Comedy Inc - Millionaire Parody, retrieved 15 August 2023
  65. ^ "Sir John Cornforth's 100th Birthday". Google. 7 September 2017.
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