Tasulopram

Tasulopram
Clinical data
ATC code	none;
Identifiers
	IUPAC name 3-(3,3-dimethyl-1-phenyl-isobenzofuran-1-yl)-N-methyl-propan-1-amine;
CAS Number	7182-51-6;
PubChem CID	23573;
ChemSpider	22042;
Chemical and physical data
Formula	C20H25NO
Molar mass	295.42 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1(C2=CC=CC=C2C(O1)(CCCNC)C3=CC=CC=C3)C;

Talsupram (5-003) is a selective norepinephrine reuptake inhibitor (NRI) which was investigated as an antidepressant in the 1960s and 1970s but was never marketed.^[1]^[2]^[3] Along with talopram], it is structurally related to the selective serotonin reuptake inhibitor (SSRI) citalopram.^[4]

References

^ Pawłowski L, Mazela H (1986). "Effects of antidepressant drugs, selective noradrenaline-or 5-hydroxytryptamine uptake inhibitors, on apomorphine-induced hypothermia in mice". Psychopharmacology. 88 (2): 240–6. PMID 3006113.
^ McConathy J, Owens MJ, Kilts CD; et al. (2004). "Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter". Nuclear Medicine and Biology. 31 (6): 705–18. doi:10.1016/j.nucmedbio.2003.05.001. PMID 15246361. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
^ Kelliher P, Kelly JP, Leonard BE, Sánchez C (2003). "Effects of acute and chronic administration of selective monoamine re-uptake inhibitors in the rat forced swim test". Psychoneuroendocrinology. 28 (3): 332–47. PMID 12573300. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
^ http://www.healyprozac.com/Book/Introduction.doc

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