CY-208,243

CY-208,243
Identifiers
	IUPAC name 4,6,6a,7,8,12b-hexahydro-7-methylindolo(4,3-ab)-phenanthridine;
CAS Number	100999-26-6 ;
PubChem CID	58144;
ChemSpider	52380 ;
UNII	8GJ4UR780B;
CompTox Dashboard (EPA)	DTXSID9042598 ;
Chemical and physical data
Formula	C19H18N2
Molar mass	274.367 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c15c4[nH]cc5CC2C(c1ccc4)c3ccccc3CN2C;
	InChI InChI=1S/C19H18N2/c1-21-11-12-5-2-3-6-14(12)19-15-7-4-8-16-18(15)13(10-20-16)9-17(19)21/h2-8,10,17,19-20H,9,11H2,1H3/t17-,19-/m1/s1 ; Key:WRNKIDLXXXIELU-IEBWSBKVSA-N ;
	(what is this?) (verify)

CY-208,243 is a drug which acts as a dopamine agonist selective for the D₁ subtype. Unlike most D₁-selective agonists, it shows efficacy in animal models of Parkinson's disease.^[1]^[2]^[3]^[4]^[5]

References

^ Gagnon C, Gomez-Mancilla B, Markstein R, Bédard PJ, Di Paolo T (July 1995). "Effect of adding the D-1 agonist CY 208-243 to chronic bromocriptine treatment of MPTP-monkeys: regional changes of brain dopamine receptors". Progress in Neuro-psychopharmacology & Biological Psychiatry. 19 (4): 667–76. doi:10.1016/0278-5846(95)00110-h. PMID 8588064. S2CID 26670068.
^ Beninger RJ, Rolfe NG (December 1995). "Dopamine D1-like receptor agonists impair responding for conditioned reward in rats". Behavioural Pharmacology. 6 (8): 785–793. doi:10.1097/00008877-199512000-00003. PMID 11224381. S2CID 23656469.
^ Luquin MR, Guillén J, Legarda I, Cruz Rodriguez M, Del Rio L, Dominguez J, Martínez-Lage JM (1996). "Pulsatile administration of D1 but not D2 dopamine agonists induces behavioral tolerance in MPTP-treated monkeys". Advances in Neurology. 69: 239–44. PMID 8615134.
^ D'Aquila PS, Panin F, Cossu M, Peana AT, Serra G (January 2003). "Dopamine D1 receptor agonists induce penile erections in rats". European Journal of Pharmacology. 460 (1): 71–4. doi:10.1016/S0014-2999(02)02881-9. PMID 12535862.
^ Salamone JD, Carlson BB, Rios C, Lentini E, Correa M, Wisniecki A, Betz A (January 2005). "Dopamine agonists suppress cholinomimetic-induced tremulous jaw movements in an animal model of Parkinsonism: tremorolytic effects of pergolide, ropinirole and CY 208-243". Behavioural Brain Research. 156 (2): 173–9. doi:10.1016/j.bbr.2004.05.019. PMID 15582103. S2CID 10255277.

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[pmid8588064-1] Gagnon C, Gomez-Mancilla B, Markstein R, Bédard PJ, Di Paolo T (July 1995). "Effect of adding the D-1 agonist CY 208-243 to chronic bromocriptine treatment of MPTP-monkeys: regional changes of brain dopamine receptors". Progress in Neuro-psychopharmacology & Biological Psychiatry. 19 (4): 667–76. doi:10.1016/0278-5846(95)00110-h. PMID 8588064. S2CID 26670068.

[pmid11224381-2] Beninger RJ, Rolfe NG (December 1995). "Dopamine D1-like receptor agonists impair responding for conditioned reward in rats". Behavioural Pharmacology. 6 (8): 785–793. doi:10.1097/00008877-199512000-00003. PMID 11224381. S2CID 23656469.

[pmid8615134-3] Luquin MR, Guillén J, Legarda I, Cruz Rodriguez M, Del Rio L, Dominguez J, Martínez-Lage JM (1996). "Pulsatile administration of D1 but not D2 dopamine agonists induces behavioral tolerance in MPTP-treated monkeys". Advances in Neurology. 69: 239–44. PMID 8615134.

[pmid12535862-4] D'Aquila PS, Panin F, Cossu M, Peana AT, Serra G (January 2003). "Dopamine D1 receptor agonists induce penile erections in rats". European Journal of Pharmacology. 460 (1): 71–4. doi:10.1016/S0014-2999(02)02881-9. PMID 12535862.

[pmid15582103-5] Salamone JD, Carlson BB, Rios C, Lentini E, Correa M, Wisniecki A, Betz A (January 2005). "Dopamine agonists suppress cholinomimetic-induced tremulous jaw movements in an animal model of Parkinsonism: tremorolytic effects of pergolide, ropinirole and CY 208-243". Behavioural Brain Research. 156 (2): 173–9. doi:10.1016/j.bbr.2004.05.019. PMID 15582103. S2CID 10255277.

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v t e Ergolines
Lysergic acid derivatives	2-Bromo-LSD (BOL-148) Amesergide Bromerguride (2-bromolisuride) Bromocriptine Cabergoline Dihydroergocornine Dihydroergocristine Dihydroergocryptine Dihydroergometrine (Dihydroergonovine, Dihydroergobasine) Dihydroergosine Dihydroergotamine Epicriptine Ergine (LSA; LA-111; Lysergamide) Ergocornine Ergocristine Ergocryptine Ergoloid (Dihydroergotoxine) Ergometrine (Ergonovine, Ergobasine) Ergometrinine Ergostine Ergotamine Ergotoxine Ergovaline Fludihydroergotamine Lisuride LY-215,840 LSH Lysergic acid Lysergic acid methyl ester Lysergine Lysergol Mergocriptine Mesulergine Metergoline Metergotamine MIPLA Methysergide Propisergide Sergolexole
Psychedelic lysergamides	1B-LSD 1cP-LSD 1P-ETH-LAD 1P-LSD AL-LAD ALD-52 BU-LAD CYP-LAD Diallyllysergamide (DAL) Dimethyllysergamide (DAM-57) ECPLA Ergonovine ETFELA ETH-LAD IP-LAD LAMPA LAE-32 LSD (lysergide) LPD-824 LSM-775 LSH LSD-Pip Lysergic Acid 2-Butylamide Lysergic Acid 2,4-Dimethylazetidide Lysergic Acid 3-Pentylamide Lysergic acid cyclobutylamide Lysergic acid cyclopentylamide Methylergometrine (Methylergonovine, Methylergobasine) MIPLA MLD-41 PARGY-LAD PRO-LAD
Clavines	9-Deacetoxyfumigaclavine C Agroclavine Chanoclavine Chanoclavine II Costaclavin Cycloclavine Elymoclavine Epoxyagroclavine Festuclavine Fumigaclavine A Fumigaclavine B Fumigaclavine C Paliclavine Penniclavine Setoclavine
Other ergolines	Acetergamine Brazergoline Cianergoline CY-208,243 Delergotrile Disulergine Dosergoside Ergoline Etisulergine Lergotrile Nicergoline Pergolide Proterguride Romergoline Terguride Tiomergine Voxergolide
Related compounds	Adrogolide Naxagolide Quinagolide
Natural sources	Achnatherum robustum (Sleepy Grass) Claviceps spp. (Ergot) Morning glory: Argyreia nervosa (Hawaiian Baby Woodrose), Ipomoea spp.(Morning Glory, Tlitliltzin, Badoh Negro), Rivea corymbosa (Coaxihuitl, Ololiúqui)