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|Other names||1-Acetyl-N,N-diethyllysergamide, ALD, N-acetyl-LSD, Acetyl lysergic acid diethylamide, d-acetyl lysergic acid diethylamide, d-acetyldiethyllysergamide|
|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||365.477 g·mol−1|
|3D model (JSmol)|
|(what is this?)|
ALD-52, also known as 1-acetyl-LSD, is a chemical analogue of lysergic acid diethylamide (LSD). It was originally discovered by Albert Hofmann but was not widely studied until the rise in popularity of psychedelics in the 1960s.
In Entry 26 of his compendium TiHKAL, which discussed LSD, chemist Alexander Shulgin touched briefly on the subject of ALD-52. His writings are vague, second-hand accounts saying doses in the 50–175 µg range have resulted in various conclusions. One account found that there was less visual distortion than with LSD and it seemed to produce less anxiety and tenseness and that it was somewhat less potent. Another informant claimed it was more effective in increasing blood pressure. Yet another informant could not tell them apart.
In The Hallucinogens by Hoffer and Osmond (1967), ALD-52 is listed as having a lower (approximately 1/5) intravenous toxicity (in rabbits), a lower (approximately 1/8) pyretogenic effect, an equal psychological effect in humans, and double the "antiserotonin" effect as compared with LSD. Human experiments have not been well documented.[medical citation needed]
It is possible ALD-52 was the active chemical in the Orange Sunshine variety of LSD that was widely available in California through 1968 and 1969. The Sonoma County underground chemistry lab of Tim Scully and Nicholas Sand was Orange Sunshine's source. It was shut down by the police, and Scully was arrested and prosecuted. This resulted in the first drug analogue trial, where Scully claimed that he and his partners did nothing illegal, because they were producing ALD-52, which was not an illicit drug. However, as the prosecution claimed, there were problems with such a rationale—ALD-52 was claimed to readily undergo hydrolysis to LSD, and secondly, the synthesis of ALD-52 required LSD. (The second point was based on the methods available in the scientific literature at the time). Scully was convicted and served time in prison.
Tim Scully has confirmed that the speculation above is incorrect. In a Reddit AMA  with the director of the movie The Sunshine Makers, he says "The Orange Sunshine we delivered was LSD 25. ALD 52 was an ill-advised desperate defense strategy that failed miserably... The story of Orange Sunshine is complicated by the fact that The Brotherhood distributed LSD from more than one manufacturer as Orange Sunshine. "Nick and I made the original Orange Sunshine in Windsor. That was the last lab I worked in making LSD. Ron Stark managed several LSD labs in Europe and most of his output was tableted and sold as Orange Sunshine. At least some of the LSD that his labs made was not pure."
ALD-52 is technically not illegal but it may fall in the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich) as an analogue of LSD
ALD-52 is not listed as an illegal substance in Denmark as of April, 2019, and its chemical class 'lysergamide' is not banned under the Analogue Act (Some LSD analogues are, however, prohibited).
ALD-52 is controlled under the NpSG as of July 18, 2019. Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.
ALD-52 is illegal in Latvia. Although it isn't officially scheduled, it is controlled as an LSD structural analog due to an amendment made on June 1, 2015.
1P-LSD is illegal to produce or sell in Romania. It is not included directly in the list of controlled substances, but it is included in an analogue act. However, it is not, as of yet, classified as illegal to use.
ALD-52 is a class A controlled drug, and is illegal to traffic, manufacture, import, export, possess, or consume in Singapore as of December 1, 2019, punishable with a minimum of five years’ imprisonment and five strokes of the cane .
Since March 2018, ALD-52 is illegal in Switzerland and has been put in the RS 812.121.11.
On June 10, 2014 the UK Advisory Council on the Misuse of Drugs (ACMD) recommended that ALD-52 be specifically named in the UK Misuse of Drugs Act as a class A drug despite not identifying it as ever having been sold or any harm associated with its use. The UK Home office accepted this advice and announced a ban of the substance to be enacted on 6 January 2015 as part of The Misuse of Drugs Act 1971 (Amendment) (No. 2) Order 2014.
ALD-52 is unscheduled in the United States. It may be considered an analogue of LSD, a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or scientific research could be prosecuted as crimes under the Federal Analogue Act.
- Lysergic acid diethylamide (LSD)
- O-Acetylpsilocin (4-AcO-DMT)
- AL-LAD (6-allyl-6-nor-lysergic acid diethylamide)
- ETH-LAD (6-ethyl-6-nor-lysergic acid diethylamide)
- PRO-LAD (6-propyl-6-nor-lysergic acid diethylamide)
- 1P-LSD (1-propionyl-lysergic acid diethylamide)
- Shulgin, Alexander; Shulgin, Ann (September 1997). TiHKAL: The Continuation. Berkeley, California: Transform Press. ISBN 0-9630096-9-9. OCLC 38503252.
- "I'm filmmaker Cosmo Feilding Mellen. I made The Sunshine Makers, a documentary about Tim Scully, who was jailed for trying to turn on the world using LSD. Expand your mind… Ask us anything!". ask me anything. reddit. Archived from the original on 2017-03-26.
- "Samlet liste over euforiserende stoffer opført på bilag 1 til bekendtgørelsen om euforiserende stoffer nr. 557 af 31. maj 2011 og stoffer reguleret herefter via ændringsbekendtgørelser" [Comprehensive list of euphoric substances listed in Appendix 1 to the Executive Order on Euphoric Substances No 557 of 31 May 2011 and substances regulated thereafter via amendments] (in Danish). June 13, 2018. Retrieved 2019-12-21.
- "Änderungen NpSG vom 18 July 2019 durch Artikel 1 der Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes". www.buzer.de. Retrieved 2019-12-21.
- "Anlage NpSG – Einzelnorm". www.gesetze-im-internet.de. Retrieved 2019-12-21.
- "§ 4 NpSG – Einzelnorm". www.gesetze-im-internet.de. Retrieved 2019-12-21.
- "Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem". LIKUMI.LV (in Latvian). Retrieved 2019-12-21.
- "Changes to Misuse Of Drugs Act (w.e.f. 1 December 2019)". www.cnb.gov.sg. Retrieved 2019-12-30.
- ACMD (10 June 2014). "Update of the Generic Definition for Tryptamines" (PDF). UK Home Office. p. 12. Archived (PDF) from the original on 6 October 2014. Retrieved 10 June 2014.
- "Erowid Analog Law Vault: Federal Controlled Substance Analogue Act Summary". www.erowid.org. Retrieved 2019-12-21.