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Cadherin 16, KSP-cadherin
Symbol CDH16
External IDs OMIM603118 MGI106671 HomoloGene2997 GeneCards: CDH16 Gene
RNA expression pattern
PBB GE CDH16 206517 at tn.png
More reference expression data
Species Human Mouse
Entrez 1014 12556
Ensembl ENSG00000166589 ENSMUSG00000031881
UniProt O75309 O88338
RefSeq (mRNA) NM_001204744 NM_001252627
RefSeq (protein) NP_001191673 NP_001239556
Location (UCSC) Chr 16:
66.91 – 66.92 Mb
Chr 8:
104.61 – 104.62 Mb
PubMed search [1] [2]

Cadherin-16 is a protein that in humans is encoded by the CDH16 gene.[1][2][3]

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development.[3]


  1. ^ Thomson RB, Ward DC, Quaggin SE, Igarashi P, Muckler ZE, Aronson PS (Oct 1998). "cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin". Genomics 51 (3): 445–51. doi:10.1006/geno.1998.5402. PMID 9721215. 
  2. ^ Thomson RB, Igarashi P, Biemesderfer D, Kim R, Abu-Alfa A, Soleimani M, Aronson PS (Aug 1995). "Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific member of the cadherin multigene family". J Biol Chem 270 (29): 17594–601. doi:10.1074/jbc.270.29.17594. PMID 7615566. 
  3. ^ a b "Entrez Gene: CDH16 cadherin 16, KSP-cadherin". 

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