CDH16

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CDH16
Identifiers
AliasesCDH16, cadherin 16
External IDsOMIM: 603118 MGI: 106671 HomoloGene: 2997 GeneCards: CDH16
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for CDH16
Genomic location for CDH16
Band16q22.1Start66,908,122 bp[1]
End66,918,917 bp[1]
RNA expression pattern
PBB GE CDH16 206517 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204744
NM_001204745
NM_001204746
NM_004062

NM_001252627
NM_001252628
NM_007663

RefSeq (protein)

NP_001191673
NP_001191674
NP_001191675
NP_004053

NP_001239556
NP_001239557
NP_031689

Location (UCSC)Chr 16: 66.91 – 66.92 MbChr 8: 104.6 – 104.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cadherin-16 is a protein that in humans is encoded by the CDH16 gene.[5][6][7]

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in the kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166589 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031881 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Thomson RB, Ward DC, Quaggin SE, Igarashi P, Muckler ZE, Aronson PS (Oct 1998). "cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin". Genomics. 51 (3): 445–51. doi:10.1006/geno.1998.5402. PMID 9721215.
  6. ^ Thomson RB, Igarashi P, Biemesderfer D, Kim R, Abu-Alfa A, Soleimani M, Aronson PS (Aug 1995). "Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific member of the cadherin multigene family". J Biol Chem. 270 (29): 17594–601. doi:10.1074/jbc.270.29.17594. PMID 7615566.
  7. ^ a b "Entrez Gene: CDH16 cadherin 16, KSP-cadherin".

Further reading[edit]

External links[edit]