CDH16

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CDH16
Identifiers
Aliases CDH16
External IDs MGI: 106671 HomoloGene: 2997 GeneCards: 1014
RNA expression pattern
PBB GE CDH16 206517 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204744
NM_001204745
NM_001204746
NM_004062

NM_001252627
NM_001252628
NM_007663

RefSeq (protein)

NP_001191673.1
NP_001191674.1
NP_001191675.1
NP_004053.1

NP_031689.1

Location (UCSC) Chr 16: 66.91 – 66.92 Mb Chr 8: 104.61 – 104.62 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cadherin-16 is a protein that in humans is encoded by the CDH16 gene.[3][4][5]

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Thomson RB, Ward DC, Quaggin SE, Igarashi P, Muckler ZE, Aronson PS (Oct 1998). "cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin". Genomics. 51 (3): 445–51. doi:10.1006/geno.1998.5402. PMID 9721215. 
  4. ^ Thomson RB, Igarashi P, Biemesderfer D, Kim R, Abu-Alfa A, Soleimani M, Aronson PS (Aug 1995). "Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific member of the cadherin multigene family". J Biol Chem. 270 (29): 17594–601. doi:10.1074/jbc.270.29.17594. PMID 7615566. 
  5. ^ a b "Entrez Gene: CDH16 cadherin 16, KSP-cadherin". 

Further reading[edit]

External links[edit]