CHRNA4

CHRNA4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LLY
Identifiers
Aliases	CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4, cholinergic receptor nicotinic alpha 4 subunit
External IDs	OMIM: 118504 MGI: 87888 HomoloGene: 592 GeneCards: CHRNA4
Gene location (Human) Chr. Chromosome 20 (human) Band 20q13.33 Start 63,343,223 bp End 63,378,401 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 H4|2 103.54 cM Start 180,660,173 bp End 180,685,339 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver cingulate gyrus prefrontal cortex amygdala Brodmann area 9 hypothalamus ganglionic eminence substantia nigra nucleus accumbens caudate nucleus Top expressed in substantia nigra visual cortex neural tube superior frontal gyrus medial dorsal nucleus lateral geniculate nucleus ventral tegmental area pretectal area lens cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function acetylcholine binding acetylcholine receptor activity ion channel activity ligand-gated ion channel activity extracellular ligand-gated ion channel activity protein binding acetylcholine-gated cation-selective channel activity transmembrane signaling receptor activity Cellular component integral component of membrane acetylcholine-gated channel complex postsynaptic membrane membrane plasma membrane synapse cell junction neuronal cell body dendrite external side of plasma membrane dopaminergic synapse integral component of presynaptic membrane integral component of plasma membrane neuron projection Biological process regulation of dopamine secretion inhibitory postsynaptic potential response to hypoxia cognition locomotory behavior regulation of membrane potential response to nicotine membrane depolarization nervous system process synaptic transmission, cholinergic ion transport response to oxidative stress respiratory gaseous exchange by respiratory system behavioral response to nicotine B cell activation neuromuscular synaptic transmission exploration behavior action potential sensory perception of pain DNA repair calcium ion transport signal transduction chemical synaptic transmission excitatory postsynaptic potential acetylcholine receptor signaling pathway ion transmembrane transport regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1137 11438 Ensembl ENSG00000101204 ENSMUSG00000027577 UniProt P43681 O70174 RefSeq (mRNA) NM_000744 NM_001256573 NM_015730 RefSeq (protein) NP_000735 NP_001243502 NP_056545 Location (UCSC) Chr 20: 63.34 – 63.38 Mb Chr 2: 180.66 – 180.69 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-4 is a protein that in humans is encoded by the CHRNA4 gene.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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|alt=Nicotine Activity on Dopaminergic Neurons edit]]

Nicotine Activity on Dopaminergic Neurons edit

See also

• Nicotinic acetylcholine receptor

External links

• CHRNA4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.