CHRNA4

CHRNA4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LLY
Identifiers
Aliases	CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4, cholinergic receptor nicotinic alpha 4 subunit
External IDs	OMIM: 118504; MGI: 87888; HomoloGene: 592; GeneCards: CHRNA4; OMA:CHRNA4 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	63,378,401 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	180,685,339 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; cingulate gyrus; ; anterior cingulate cortex; ; right frontal lobe; ; prefrontal cortex; ; amygdala; ; Brodmann area 9; ; gonad; ; C1 segment; ; hypothalamus;
	Top expressed in
	lumbar subsegment of spinal cord; ; right kidney; ; substantia nigra; ; visual cortex; ; primary visual cortex; ; neural tube; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; medial dorsal nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	acetylcholine binding; acetylcholine receptor activity; ion channel activity; ligand-gated ion channel activity; extracellular ligand-gated ion channel activity; protein binding; acetylcholine-gated cation-selective channel activity; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; acetylcholine-gated channel complex; postsynaptic membrane; membrane; plasma membrane; synapse; cell junction; soma; dendrite; external side of plasma membrane; dopaminergic synapse; integral component of presynaptic membrane; integral component of plasma membrane; neuron projection;
Biological process	regulation of dopamine secretion; inhibitory postsynaptic potential; response to hypoxia; cognition; locomotory behavior; regulation of membrane potential; response to nicotine; membrane depolarization; nervous system process; synaptic transmission, cholinergic; ion transport; response to oxidative stress; respiratory gaseous exchange by respiratory system; behavioral response to nicotine; B cell activation; neuromuscular synaptic transmission; exploration behavior; action potential; sensory perception of pain; DNA repair; calcium ion transport; signal transduction; chemical synaptic transmission; excitatory postsynaptic potential; acetylcholine receptor signaling pathway; ion transmembrane transport; regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	1137
	11438
	ENSG00000101204
	ENSMUSG00000027577
	P43681
	O70174
	NM_000744; NM_001256573
	NM_015730
	NP_000735; NP_001243502
	NP_056545
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-4 is a protein that in humans is encoded by the CHRNA4 gene.^[5]^[6]

Template:PBB Summary

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Nicotine Activity on Dopaminergic Neurons edit]]

Nicotine Activity on Dopaminergic Neurons edit

^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101204 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027577 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988.
^ "Entrez Gene: CHRNA4 cholinergic receptor, nicotinic, alpha 4".

External links

CHRNA4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Template:PBB Controls

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[WikiPathways-7] The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101204 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027577 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1505988-5] Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988.

[entrez-6] "Entrez Gene: CHRNA4 cholinergic receptor, nicotinic, alpha 4".

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[§ 1]

CHRNA4

Interactive pathway map

See also

References

Further reading

External links