Extranodal NK/T-cell lymphoma, nasal type

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Extranodal NK-T-cell lymphoma
Classification and external resources
Specialty oncology
ICD-10 C86.0
ICD-O M9719/3
MeSH D054391

Extranodal NK/T-cell lymphoma, nasal type[1][2] which was known as angiocentric lymphoma in the REAL classification,[1] and also as nasal-type NK lymphoma,[3] NK/T-cell lymphoma,[3] and polymorphic/malignant midline reticulosis[3] is a cutaneous condition which in Korea is reported to be the most common form of cutaneous lymphoma after mycosis fungoides.[4]:739

Extranodal NK-T-cell lymphoma is a type of lymphoma.[5][6][7]

It is called "extranodal" to emphasize that the location is typically not in the lymph node, and is sometimes further qualified as "nasal type". The nasal cavity, nasopharynx and upper aerodigestive tract are often involved, although extranasal presentations do occur (skin, gastrointestinal tract, eye, testis, lung, soft tissue).[1] There is a strong association with Epstein–Barr virus.[1][8][9]

See also[edit]


  1. ^ a b c d Jaffe, ES; Harris NL, Vardiman JW, Campo E, Arber, DA. (2011). Hematopathology (1st ed.). Elsevier Saunders. ISBN 9780721600406. 
  2. ^ Swerdlow, Steven H.; International Agency for Research on Cancer; World Health Organization (2008). WHO classification of tumours of haematopoietic and lymphoid tissues. World Health Organization classification of tumours 2 (4th ed.). International Agency for Research on Cancer. ISBN 9789283224310. 
  3. ^ a b c Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0. 
  4. ^ James, William D.; Berger, Timothy G. et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. 
  5. ^ Lee J, Suh C, Park YH et al. (February 2006). "Extranodal natural killer T-cell lymphoma, nasal-type: a prognostic model from a retrospective multicenter study". J. Clin. Oncol. 24 (4): 612–8. doi:10.1200/JCO.2005.04.1384. PMID 16380410. 
  6. ^ Lee J, Park YH, Kim WS et al. (July 2005). "Extranodal nasal type NK/T-cell lymphoma: elucidating clinical prognostic factors for risk-based stratification of therapy". Eur. J. Cancer 41 (10): 1402–8. doi:10.1016/j.ejca.2005.03.010. PMID 15963893. 
  7. ^ Lee J, Au WY, Park MJ et al. (December 2008). "Autologous hematopoietic stem cell transplantation in extranodal natural killer/T cell lymphoma: a multinational, multicenter, matched controlled study". Biol. Blood Marrow Transplant. 14 (12): 1356–64. doi:10.1016/j.bbmt.2008.09.014. PMID 19041057. 
  8. ^ Stadlmann S, Fend F, Moser P et al. (November 2001). "Epstein-Barr virus-associated extranodal NK/T-cell lymphoma, nasal type of the hypopharynx, in a renal allograft recipient: case report and review of literature". Hum. Pathol. 32 (11): 1264–8. doi:10.1053/hupa.2001.28962. PMID 11727268. 
  9. ^ Ferenczi K, Summers P, Aubert P et al. (December 2008). "A case of CD30+ nasal natural killer/T-cell lymphoma". Am J Dermatopathol 30 (6): 567–71. doi:10.1097/DAD.0b013e318184bc3f. PMID 19033930.