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Lysine (K)-specific methyltransferase 2C
Protein MLL3 PDB 2YSM.png
Rendering based on PDB 2YSM.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols KMT2C ; HALR; MLL3
External IDs OMIM606833 MGI2444959 HomoloGene46480 GeneCards: KMT2C Gene
EC number
Species Human Mouse
Entrez 58508 231051
Ensembl ENSG00000055609 ENSMUSG00000038056
UniProt Q8NEZ4 Q8BRH4
RefSeq (mRNA) NM_021230 NM_001081383
RefSeq (protein) NP_733751 NP_001074852
Location (UCSC) Chr 7:
152.13 – 152.44 Mb
Chr 5:
25.27 – 25.5 Mb
PubMed search [1] [2]

Lysine N-methyltransferase 2C (KMT2C) also known as myeloid/lymphoid or mixed-lineage leukemia protein 3 (MLL3) is an enzyme that in humans is encoded by the KMT2C gene.[1][2]


This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT-hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]


MLL3 has been shown to interact with NCOA6[3] and RBBP5.[3]


  1. ^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331. 
  2. ^ a b "Entrez Gene: MLL3 myeloid/lymphoid or mixed-lineage leukemia 3". 
  3. ^ a b Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW (Jan 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Molecular and Cellular Biology 23 (1): 140–9. doi:10.1128/MCB.23.1.140-149.2003. PMC 140670. PMID 12482968. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.