CYP2C9: Difference between revisions

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{{protein
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
⚫
|Name=cytochrome P450, family 2, subfamily C, polypeptide 9
{{PBB_Controls
⚫
|caption=Ribbon diagram of CYP2C9, [[heme]] group visible at center. From {{PDB|1OG2}}.
| update_page = yes
⚫
|image=CYP2C9 1OG2.png
| require_manual_inspection = no
⚫
|HGNCid=2623
| update_protein_box = yes
⚫
|Symbol=CYP2C9
| update_summary = no
|AltSymbols=CYP2C10
| update_citations = yes
|EntrezGene=1559
}}
⚫
|OMIM=601130

|RefSeq=NM_000771
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
|UniProt=P11712
{{GNF_Protein_box
|PDB=
⚫
| image = CYP2C9 1OG2.png
⚫
|ECnumber=
⚫
| image_source = Ribbon diagram of CYP2C9, [[heme]] group visible at center. From {{PDB|1OG2}}.
|Chromosome=10
| PDB = {{PDB2|1og2}}, {{PDB2|1og5}}, {{PDB2|1r9o}}
|Arm=q
⚫
| Name = Cytochrome P450, family 2, subfamily C, polypeptide 9
|Band=24.1
⚫
| HGNCid = 2623
|LocusSupplementaryData=
⚫
| Symbol = CYP2C9
| AltSymbols =; CYP2C; CPC9; CYP2C10; MGC149605; MGC88320; P450 MP-4; P450 PB-1; P450IIC9
⚫
| OMIM = 601130
⚫
| ECnumber =
| Homologene = 86657
| MGIid = 103238
| GeneAtlas_image1 = PBB_GE_CYP2C9_214421_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_CYP2C9_216025_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CYP2C9_216661_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0016712 |text = oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen}} {{GNF_GO|id=GO:0018675 |text = (S)-limonene 6-monooxygenase activity}} {{GNF_GO|id=GO:0018676 |text = (S)-limonene 7-monooxygenase activity}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1559
| Hs_Ensembl = ENSG00000138109
| Hs_RefseqProtein = NP_000762
| Hs_RefseqmRNA = NM_000771
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 96688418
| Hs_GenLoc_end = 96739137
| Hs_Uniprot = P11712
| Mm_EntrezGene = 13095
| Mm_Ensembl = ENSMUSG00000003053
| Mm_RefseqmRNA = NM_007815
| Mm_RefseqProtein = NP_031841
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 39340422
| Mm_GenLoc_end = 39384010
| Mm_Uniprot = Q3UEF2
}}
}}
}}
'''Cytochrome P450 2C9''' (abbreviated '''CYP2C9'''), a member of the [[cytochrome P450]] mixed-function oxidase system, is involved in the metabolism of [[xenobiotic]]s in the body. It is involved in the metabolism of several important groups of drugs including many [[non-steroidal anti-inflammatory drug]]s (NSAIDs) and [[sulfonylurea]]s.
'''Cytochrome P450 2C9''' (abbreviated '''CYP2C9'''), a member of the [[cytochrome P450]] mixed-function oxidase system, is involved in the metabolism of [[xenobiotic]]s in the body. It is involved in the metabolism of several important groups of drugs including many [[non-steroidal anti-inflammatory drug]]s (NSAIDs) and [[sulfonylurea]]s.
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== See also ==
== See also ==
*[[Cytochrome P450 oxidase]]
*[[Cytochrome P450 oxidase]]

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Goldstein JA, de Morais SM |title=Biochemistry and molecular biology of the human CYP2C subfamily. |journal=Pharmacogenetics |volume=4 |issue= 6 |pages= 285-99 |year= 1995 |pmid= 7704034 |doi= }}
*{{cite journal | author=Miners JO, Birkett DJ |title=Cytochrome P4502C9: an enzyme of major importance in human drug metabolism. |journal=British journal of clinical pharmacology |volume=45 |issue= 6 |pages= 525-38 |year= 1998 |pmid= 9663807 |doi= }}
*{{cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129-65 |year= 1999 |pmid= 9890157 |doi= }}
*{{cite journal | author=Henderson RF |title=Species differences in the metabolism of olefins: implications for risk assessment. |journal=Chem. Biol. Interact. |volume=135-136 |issue= |pages= 53-64 |year= 2001 |pmid= 11397381 |doi= }}
*{{cite journal | author=Xie HG, Prasad HC, Kim RB, Stein CM |title=CYP2C9 allelic variants: ethnic distribution and functional significance. |journal=Adv. Drug Deliv. Rev. |volume=54 |issue= 10 |pages= 1257-70 |year= 2003 |pmid= 12406644 |doi= }}
*{{cite journal | author=Palkimas MP, Skinner HM, Gandhi PJ, Gardner AJ |title=Polymorphism induced sensitivity to warfarin: a review of the literature. |journal=J. Thromb. Thrombolysis |volume=15 |issue= 3 |pages= 205-12 |year= 2004 |pmid= 14739630 |doi= 10.1023/B:THRO.0000011376.12309.af }}
*{{cite journal | author=Daly AK, Aithal GP |title=Genetic regulation of warfarin metabolism and response. |journal=Seminars in vascular medicine |volume=3 |issue= 3 |pages= 231-8 |year= 2004 |pmid= 15199455 |doi= 10.1055/s-2003-44458 }}
*{{cite journal | author=García-Martín E, Martínez C, Ladero JM, Agúndez JA |title=Interethnic and intraethnic variability of CYP2C8 and CYP2C9 polymorphisms in healthy individuals. |journal=Molecular diagnosis & therapy |volume=10 |issue= 1 |pages= 29-40 |year= 2007 |pmid= 16646575 |doi= }}
}}
{{refend}}


{{Cytochrome P450}}
{{Cytochrome P450}}

Revision as of 23:18, 10 November 2007

Template:PBB Controls

CYP2C9
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesCYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9, cytochrome P450 family 2 subfamily C member 9, Cytochrome P450 2C9, P450-2C9
External IDsOMIM: 601130 MGI: 1919553 HomoloGene: 133566 GeneCards: CYP2C9
EC number1.14.14.51
Orthologs
SpeciesHumanMouse
Entrez

1559

72303

Ensembl

ENSG00000138109

ENSMUSG00000067231

UniProt

P11712

n/a

RefSeq (mRNA)

NM_000771

NM_028191

RefSeq (protein)

NP_000762

n/a

Location (UCSC)Chr 10: 94.94 – 94.99 MbChr 19: 39.05 – 39.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytochrome P450 2C9 (abbreviated CYP2C9), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. It is involved in the metabolism of several important groups of drugs including many non-steroidal anti-inflammatory drugs (NSAIDs) and sulfonylureas.

Genetic polymorphism exists for CYP2C9 expression, with approximately 1–3% of Caucasian populations being poor metabolisers with no CYP2C9 function.

CYP2C9 Ligands

Selected inducers, inhibitors and substrates of CYP2C9[5]
Substrates Inhibitors Inducers
Often mentioned [6]:

Less often mentioned[6]:

Strong [7]:


others:

Often mentioned [6]:

Less often mentioned:

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138109 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067231 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Where classes of agents are listed, there may be exceptions within the class
  6. ^ a b c Mentioned both in the reference named FASS and were previously mentioned in Wikipedia. Further contributions may follow other systems
  7. ^ Swedish environmental classification of pharmaceuticals Facts for prescribers (Fakta för förskrivare)

Further reading

Template:PBB Further reading

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