Glimepiride
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| Systematic (IUPAC) name | |
|---|---|
| 3-ethyl-4-methyl-N-(4-[N-((1r,4r)-4-methylcyclohexylcarbamoyl)sulfamoyl]phenethyl)-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide | |
| Identifiers | |
| CAS number | 93479-97-1 |
| ATC code | A10BB12 |
| PubChem | 3476 |
| DrugBank | APRD00381 |
| Chemical data | |
| Formula | C24H34N4O5S |
| Mol. mass | 490.617 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | >99.5% |
| Metabolism | ? |
| Half life | 5 Hours |
| Excretion | Urine & Fecal |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | Oral |
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Glimepiride is a medium-to-long acting sulfonylurea anti-diabetic drug. It is marketed as Amaryl by Sanofi-Aventis and Glyree by Ipca. Glimepiride is the first third-generation sulfonylurea, and is very potent.
It is sometimes classified as third-generation,[1] and sometimes classified as second-generation.[2]
Contents |
[edit] Indications
Type 2 diabetes (NIDDM).
[edit] Adverse effects
GI disturbance, rarely thrombocytopenia , leukopenia, hemolytic anemia, occasionally allergic reactions occur. In the initial weeks of treatment, the risk of hypoglycemia may be increased.
[edit] Contraindications
-Hypersensitivity to glimepiride or other sulfonylureas.
-Pregnancy
[edit] Interactions
With NSAIDs like Salicylates, Sulphonamides, Chloramphenicol, coumadin and probencid may potentiate the hypoglycemic action of glimepiride. Thiazides, other diuretic, phothiazides, thyroid products, oral contraceptives, phenytoin tend to produce hyperglycemia.
[edit] Pharmacology
With glimepiride GI absorption is complete, with no interference of meals. Significant absorption of glimepiride was seen within 1 hour, and distributed throughout the body, bound to the plasma protein to an extent of 99.5% and it is metabolized by oxidative biotransformation and 60% is excreted in the urine, the remaining being excreted in the feces.
[edit] Mechanism of action
Glimepiride lowers the blood glucose level by stimulating pancreatic beta cells to produce more insulin and by inducing increased activity of intracellular insulin receptors.
It is considered a secretagogue.[3]
[edit] References
- ^ Hamaguchi T, Hirose T, Asakawa H, et al. (December 2004). "Efficacy of glimepiride in type 2 diabetic patients treated with glibenclamide". Diabetes Res. Clin. Pract. 66 Suppl 1: S129–32. doi:. PMID 15563963. http://linkinghub.elsevier.com/retrieve/pii/S0168-8227(04)00148-2.
- ^ Davis SN (2004). "The role of glimepiride in the effective management of Type 2 diabetes". J. Diabetes Complicat. 18 (6): 367–76. doi:. PMID 15531188. http://linkinghub.elsevier.com/retrieve/pii/S1056-8727(04)00078-9.
- ^ Nissen SE, Nicholls SJ, Wolski K, et al. (April 2008). "Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the PERISCOPE randomized controlled trial". JAMA 299 (13): 1561–73. doi:. PMID 18378631. http://jama.ama-assn.org/cgi/pmidlookup?view=long&pmid=18378631.
[edit] External links
- http://www.drugdigest.org/DD/DVH/Uses/1,3915,298|Amaryl%2BTablets|2805,00.html*
- http://www.theodora.com/drugs/amaryl_tablets_sanofi_aventis.html
- http://www.rxlist.com/cgi/generic/glimepiride.htm
- http://www.pharmgkb.org/do/serve?objId=213&objCls=DrugProperties
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