Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus. NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand.
Smith FB, Connor JM, Lee AJ, et al. (2004). "Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease.". Thromb. Res.112 (4): 209–16. doi:10.1016/j.thromres.2003.11.010. PMID14987913.
Lanier LL, Chang C, Phillips JH (1994). "Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes.". J. Immunol.153 (6): 2417–28. PMID8077657.
Poggi A, Costa P, Morelli L, et al. (1996). "Expression of human NKRP1A by CD34+ immature thymocytes: NKRP1A-mediated regulation of proliferation and cytolytic activity.". Eur. J. Immunol.26 (6): 1266–72. doi:10.1002/eji.1830260613. PMID8647203.
Renedo M, Arce I, Rodríguez A, et al. (1997). "The human natural killer gene complex is located on chromosome 12p12-p13.". Immunogenetics46 (4): 307–11. doi:10.1007/s002510050276. PMID9218532.
Poggi A, Costa P, Zocchi MR, Moretta L (1997). "Phenotypic and functional analysis of CD4+ NKRP1A+ human T lymphocytes. Direct evidence that the NKRP1A molecule is involved in transendothelial migration.". Eur. J. Immunol.27 (9): 2345–50. doi:10.1002/eji.1830270932. PMID9341779.
Poggi A, Rubartelli A, Moretta L, Zocchi MR (1998). "Expression and function of NKRP1A molecule on human monocytes and dendritic cells.". Eur. J. Immunol.27 (11): 2965–70. doi:10.1002/eji.1830271132. PMID9394825.