CD69

CD69 molecule
PDB rendering based on 1e87.
Available structures PDB 1E87, 1E8I, 1FM5, 3CCK, 3HUP
Identifiers
Symbols	CD69; AIM; BL-AC/P26; CLEC2C; EA1; GP32/28; MLR-3
External IDs	OMIM: 107273 MGI: 88343 HomoloGene: 90963 GeneCards: CD69 Gene
Gene Ontology Molecular function • transmembrane signaling receptor activity • binding • sugar binding Cellular component • integral to plasma membrane • external side of plasma membrane • membrane Biological process • cellular response to drug Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	969	12515
Ensembl	ENSG00000110848	ENSMUSG00000030156
UniProt	Q07108	P37217
RefSeq (mRNA)	NM_001781.2	NM_001033122.3
RefSeq (protein)	NP_001772.1	NP_001028294.1
Location (UCSC)	Chr 12: 9.91 – 9.91 Mb	Chr 6: 129.22 – 129.23 Mb
PubMed search	[1]	[2]

CD69 (Cluster of Differentiation 69) is a human transmembrane C-Type lectin protein encoded by the CD69 gene.

The activation of T lymphocytes, both in vivo and in vitro, induces expression of CD69. This molecule, which appears to be the earliest inducible cell surface glycoprotein acquired during lymphoid activation, is involved in lymphocyte proliferation and functions as a signal-transmitting receptor in lymphocytes, including natural killer (NK) cells, and platelets (Cambiaggi et al., 1992) [supplied by OMIM].

See also

• Cluster of differentiation

Further reading

• Cambiaggi C, Scupoli MT, Cestari T, et al. (1992). "Constitutive expression of CD69 in interspecies T-cell hybrids and locus assignment to human chromosome 12.". Immunogenetics 36 (2): 117–20. doi:10.1007/BF00215288. PMID 1612643. 
• López-Cabrera M, Muñoz E, Blázquez MV, et al. (1995). "Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements.". J. Biol. Chem. 270 (37): 21545–51. doi:10.1074/jbc.270.37.21545. PMID 7665567. 
• Bezouska K, Nepovím A, Horváth O, et al. (1995). "CD 69 antigen of human lymphocytes is a calcium-dependent carbohydrate-binding protein.". Biochem. Biophys. Res. Commun. 208 (1): 68–74. doi:10.1006/bbrc.1995.1306. PMID 7887967. 
• Santis AG, López-Cabrera M, Hamann J, et al. (1994). "Structure of the gene coding for the human early lymphocyte activation antigen CD69: a C-type lectin receptor evolutionarily related with the gene families of natural killer cell-specific receptors.". Eur. J. Immunol. 24 (7): 1692–7. doi:10.1002/eji.1830240735. PMID 8026529. 
• Ziegler SF, Ramsdell F, Hjerrild KA, et al. (1993). "Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens.". Eur. J. Immunol. 23 (7): 1643–8. doi:10.1002/eji.1830230737. PMID 8100776. 
• López-Cabrera M, Santis AG, Fernández-Ruiz E, et al. (1993). "Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors". J. Exp. Med. 178 (2): 537–47. doi:10.1084/jem.178.2.537. PMC 2191117. PMID 8340758. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2191117. 
• Hamann J, Fiebig H, Strauss M (1993). "Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain". J. Immunol. 150 (11): 4920–7. PMID 8496594. 
• Krowka JF, Cuevas B, Maron DC, et al. (1996). "Expression of CD69 after in vitro stimulation: a rapid method for quantitating impaired lymphocyte responses in HIV-infected individuals". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 11 (1): 95–104. doi:10.1097/00042560-199601010-00013. PMID 8528739. 
• Iafrate AJ, Bronson S, Skowronski J (1997). "Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling". EMBO J. 16 (4): 673–84. doi:10.1093/emboj/16.4.673. PMC 1169669. PMID 9049297. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169669. 
• Vance BA, Bennett MJ, Ward Y, et al. (1999). "Distinct but dispensable N-glycosylation of human CD69 proteins". Arch. Biochem. Biophys. 368 (2): 214–20. doi:10.1006/abbi.1999.1322. PMID 10441371. 
• Blázquez MV, Macho A, Ortiz C, et al. (1999). "Extracellular HIV type 1 Tat protein induces CD69 expression through NF-kappaB activation: possible correlation with cell surface Tat-binding proteins". AIDS Res. Hum. Retroviruses 15 (13): 1209–18. doi:10.1089/088922299310304. PMID 10480634. 
• Llera AS, Viedma F, Sánchez-Madrid F, Tormo J (2001). "Crystal structure of the C-type lectin-like domain from the human hematopoietic cell receptor CD69". J. Biol. Chem. 276 (10): 7312–9. doi:10.1074/jbc.M008573200. PMID 11036086. 
• Natarajan K, Sawicki MW, Margulies DH, Mariuzza RA (2001). "Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells". Biochemistry 39 (48): 14779–86. doi:10.1021/bi0018180. PMID 11101293. 
• Liu X, Schrager JA, Lange GD, Marsh JW (2001). "HIV Nef-mediated cellular phenotypes are differentially expressed as a function of intracellular Nef concentrations". J. Biol. Chem. 276 (35): 32763–70. doi:10.1074/jbc.M101025200. PMID 11438519. 
• Diament D, Brunialti MK, Romero EC, et al. (2002). "Peripheral Blood Mononuclear Cell Activation Induced by Leptospira interrogans Glycolipoprotein". Infect. Immun. 70 (4): 1677–83. doi:10.1128/IAI.70.4.1677-1683.2002. PMC 127819. PMID 11895929. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=127819. 
• Yoshimura C, Yamaguchi M, Iikura M, et al. (2002). "Activation markers of human basophils: CD69 expression is strongly and preferentially induced by IL-3". J. Allergy Clin. Immunol. 109 (5): 817–23. doi:10.1067/mai.2002.123532. PMID 11994706. 
• Pisegna S, Zingoni A, Pirozzi G, et al. (2002). "Src-dependent Syk activation controls CD69-mediated signaling and function on human NK cells". J. Immunol. 169 (1): 68–74. PMID 12077230. 
• Liu CC, Huang KJ, Lin YS, et al. (2002). "Transient CD4/CD8 ratio inversion and aberrant immune activation during dengue virus infection". J. Med. Virol. 68 (2): 241–52. doi:10.1002/jmv.10198. PMID 12210415. 
• Foerster M, Haefner D, Kroegel C (2002). "Bcl-2-mediated regulation of CD69-induced apoptosis of human eosinophils: identification and characterization of a novel receptor-induced mechanism and relationship to CD95-transduced signalling". Scand. J. Immunol. 56 (4): 417–28. doi:10.1046/j.1365-3083.2002.01111.x. PMID 12234263. 
• Weigel G, Griesmacher A, Karimi A, et al. (2003). "Effect of mycophenolate mofetil therapy on lymphocyte activation in heart transplant recipients". J. Heart Lung Transplant. 21 (10): 1074–9. doi:10.1016/S1053-2498(02)00440-0. PMID 12398872. 

External links

• MeSH CD69+protein,+human