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Killer cell lectin-like receptor subfamily D, member 1
Protein KLRD1 PDB 1b6e.png
PDB rendering based on 1b6e.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols KLRD1 ; CD94
External IDs OMIM602894 MGI1196275 HomoloGene1705 GeneCards: KLRD1 Gene
RNA expression pattern
PBB GE KLRD1 207795 s at tn.png
PBB GE KLRD1 207796 x at tn.png
PBB GE KLRD1 210606 x at tn.png
More reference expression data
Species Human Mouse
Entrez 3824 16643
Ensembl ENSG00000134539 ENSMUSG00000030165
UniProt Q13241 O54707
RefSeq (mRNA) NM_001114396 NM_010654
RefSeq (protein) NP_001107868 NP_034784
Location (UCSC) Chr 12:
10.38 – 10.47 Mb
Chr 6:
129.59 – 129.6 Mb
PubMed search [1] [2]

CD94 (Cluster of Differentiation 94), also known as killer cell lectin-like receptor subfamily D, member 1 (KLRD1) is a human gene.[1]

The protein encoded by CD94 gene is a lectin, cluster of differentiation and a receptor that is involved in cell signaling and is expressed on the surface of natural killer cells in the innate immune system. CD94 pairs with the NKG2 molecule as a heterodimer. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells.

Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. KLRD1 has two alternatively spliced variants that differ in the presence or absence of exon 2 sequence.[1]


KLRD1 has been shown to interact with KLRC2.[2][3]

See also[edit]


  1. ^ a b "Entrez Gene: KLRD1 killer cell lectin-like receptor subfamily D, member 1". 
  2. ^ Lazetic, S; Chang C; Houchins J P; Lanier L L; Phillips J H (Dec 1996). "Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits". J. Immunol. (UNITED STATES) 157 (11): 4741–5. ISSN 0022-1767. PMID 8943374. 
  3. ^ Ding, Y; Sumitran S; Holgersson J (May 1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells". Scand. J. Immunol. (ENGLAND) 49 (5): 459–65. doi:10.1046/j.1365-3083.1999.00566.x. ISSN 0300-9475. PMID 10320637. 

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