Sunifiram: Difference between revisions
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Article didn't say what kind of effects. Effects 1-3 in referenced article are all antagonistic to chemically induced amnesia. |
Added study showing AMPA-r activation in the anti-amnesiac effects of sunifiram |
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'''Sunifiram''' ('''DM-235''') is a [[piperazine]] derived [[research chemical]] which has anti-amnesiac effects in animal studies with significantly higher potency than [[piracetam]].<ref name=Gualtieri2016rev>{{cite journal | vauthors = Gualtieri F | title = Unifi nootropics from the lab to the web: a story of academic (and industrial) shortcomings | journal = Journal of Enzyme Inhibition and Medicinal Chemistry | volume = 31 | issue = 2 | pages = 187–94 | year = 2016 | pmid=25831025 | doi=10.3109/14756366.2015.1021252}}</ref> |
'''Sunifiram''' ('''DM-235''') is a [[piperazine]] derived [[research chemical]] which has anti-amnesiac effects in animal studies with significantly higher potency than [[piracetam]].<ref name=Gualtieri2016rev>{{cite journal | vauthors = Gualtieri F | title = Unifi nootropics from the lab to the web: a story of academic (and industrial) shortcomings | journal = Journal of Enzyme Inhibition and Medicinal Chemistry | volume = 31 | issue = 2 | pages = 187–94 | year = 2016 | pmid=25831025 | doi=10.3109/14756366.2015.1021252}}</ref> Sunifiram is closely related to, and derived from, [[unifiram]]. The anti-amnesiac effect of both chemicals has been shown to involve AMPA-receptor activation.<ref>{{Cite journal |
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| last1 = Galeotti | first1 = N. |
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| last2 = Ghelardini | first2 = C. |
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| last3 = Pittaluga | first3 = A. |
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| last4 = Pugliese | first4 = A. |
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| last5 = Bartolini | first5 = A. |
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| last6 = Manetti | first6 = D. |
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| last7 = Romanelli | first7 = M. |
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| last8 = Gualtieri | first8 = F. |
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| title = AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram) |
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| journal = Naunyn-Schmiedeberg's archives of pharmacology |
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| volume = 368 |
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| issue = 6 |
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| pages = 538–545 |
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| year = 2003 |
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| pmid = 14600801 |
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| doi = 10.1007/s00210-003-0812-6 |
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}}</ref> |
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As of |
As of 2017 it had not been subjected to toxicology testing, nor to any human [[clinical trials]], and is not approved for use anywhere in the world.<ref name=Gualtieri2016rev/> |
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==References== |
==References== |
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Revision as of 09:54, 7 March 2017
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| Formula | C14H18N2O2 |
| Molar mass | 246.304 g/mol g·mol−1 |
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Sunifiram (DM-235) is a piperazine derived research chemical which has anti-amnesiac effects in animal studies with significantly higher potency than piracetam.[1] Sunifiram is closely related to, and derived from, unifiram. The anti-amnesiac effect of both chemicals has been shown to involve AMPA-receptor activation.[2]
As of 2017 it had not been subjected to toxicology testing, nor to any human clinical trials, and is not approved for use anywhere in the world.[1]
References
- ^ a b Gualtieri F (2016). "Unifi nootropics from the lab to the web: a story of academic (and industrial) shortcomings". Journal of Enzyme Inhibition and Medicinal Chemistry. 31 (2): 187–94. doi:10.3109/14756366.2015.1021252. PMID 25831025.
- ^ Galeotti, N.; Ghelardini, C.; Pittaluga, A.; Pugliese, A.; Bartolini, A.; Manetti, D.; Romanelli, M.; Gualtieri, F. (2003). "AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram)". Naunyn-Schmiedeberg's archives of pharmacology. 368 (6): 538–545. doi:10.1007/s00210-003-0812-6. PMID 14600801.