ATP2A2

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Identifiers
Symbol	ATP2A2
Alt. symbols	ATP2B, DAR
NCBI gene	488
HGNC	812
OMIM	108740
RefSeq	NM_001681
UniProt	P16615
Other data
EC number	3.6.3.8
Locus	Chr. 12 q23-q24
Search for Structures Swiss-model Domains InterPro

ATP2A2 is an ATPase associated with Darier's disease and Acrokeratosis verruciformis.

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms.

External links

• ATP2A2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)