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This article is about the ras homolog gene family. For the Rayburn House Office Building, see Rayburn House Office Building.
Ras homolog family member B
Protein RHOB PDB 2fv8.png
PDB rendering based on 2fv8.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RHOB ; ARH6; ARHB; MST081; MSTP081; RHOH6
External IDs OMIM165370 MGI107949 HomoloGene68377 ChEMBL: 1795102 GeneCards: RHOB Gene
EC number
RNA expression pattern
PBB GE RHOB 212099 at tn.png
More reference expression data
Species Human Mouse
Entrez 388 11852
Ensembl ENSG00000143878 ENSMUSG00000054364
UniProt P62745 P62746
RefSeq (mRNA) NM_004040 NM_007483
RefSeq (protein) NP_004031 NP_031509
Location (UCSC) Chr 2:
20.45 – 20.45 Mb
Chr 12:
8.5 – 8.5 Mb
PubMed search [1] [2]

Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene.[1][2]

RHOB is a member of the Rho GTP-binding protein family.[3]


RHOB has been shown to interact with CIT,[4] ARHGEF3,[5] ARHGDIG[6] and RHPN2.[7]


  1. ^ "Entrez Gene: RHOB ras homolog gene family, member B". 
  2. ^ Chardin P, Madaule P, Tavitian A (March 1988). "Coding sequence of human rho cDNAs clone 6 and clone 9". Nucleic Acids Research 16 (6): 2717. doi:10.1093/nar/16.6.2717. PMC 336400. PMID 3283705. 
  3. ^ Wennerberg K, Der CJ (March 2004). "Rho-family GTPases: it's not only Rac and Rho (and I like it)". Journal of Cell Science 117 (Pt 8): 1301–12. doi:10.1242/jcs.01118. PMID 15020670. 
  4. ^ Madaule, P; Furuyashiki T; Reid T; Ishizaki T; Watanabe G; Morii N; Narumiya S (Dec 1995). "A novel partner for the GTP-bound forms of rho and rac". FEBS Lett. (NETHERLANDS) 377 (2): 243–8. doi:10.1016/0014-5793(95)01351-2. ISSN 0014-5793. PMID 8543060. 
  5. ^ Arthur, William T; Ellerbroek Shawn M; Der Channing J; Burridge Keith; Wennerberg Krister (Nov 2002). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. (United States) 277 (45): 42964–72. doi:10.1074/jbc.M207401200. ISSN 0021-9258. PMID 12221096. 
  6. ^ Zalcman, G; Closson V; Camonis J; Honoré N; Rousseau-Merck M F; Tavitian A; Olofsson B (Nov 1996). "RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. (UNITED STATES) 271 (48): 30366–74. doi:10.1074/jbc.271.48.30366. ISSN 0021-9258. PMID 8939998. 
  7. ^ Mircescu, Hortensia; Steuve Séverine; Savonet Valérie; Degraef Chantal; Mellor Harry; Dumont Jacques E; Maenhaut Carine; Pirson Isabelle (Dec 2002). "Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP". Eur. J. Biochem. (Germany) 269 (24): 6241–9. doi:10.1046/j.1432-1033.2002.03343.x. ISSN 0014-2956. PMID 12473120. 

Further reading[edit]

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