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This article is about the ras homolog gene family. For the Rayburn House Office Building, see Rayburn House Office Building.
Protein RHOB PDB 2fv8.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6, ras homolog family member B
External IDs OMIM: 165370 MGI: 107949 HomoloGene: 68377 GeneCards: RHOB
RNA expression pattern
PBB GE RHOB 212099 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 2: 20.45 – 20.45 Mb Chr 12: 8.5 – 8.5 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene.[3][4]

RHOB is a member of the Rho GTP-binding protein family.[5]


RHOB has been shown to interact with CIT,[6] ARHGEF3,[7] ARHGDIG[8] and RHPN2.[9]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: RHOB ras homolog gene family, member B". 
  4. ^ Chardin P, Madaule P, Tavitian A (March 1988). "Coding sequence of human rho cDNAs clone 6 and clone 9". Nucleic Acids Research. 16 (6): 2717. doi:10.1093/nar/16.6.2717. PMC 336400Freely accessible. PMID 3283705. 
  5. ^ Wennerberg K, Der CJ (March 2004). "Rho-family GTPases: it's not only Rac and Rho (and I like it)". Journal of Cell Science. 117 (Pt 8): 1301–12. doi:10.1242/jcs.01118. PMID 15020670. 
  6. ^ Madaule, P; Furuyashiki T; Reid T; Ishizaki T; Watanabe G; Morii N; Narumiya S (Dec 1995). "A novel partner for the GTP-bound forms of rho and rac". FEBS Lett. NETHERLANDS. 377 (2): 243–8. doi:10.1016/0014-5793(95)01351-2. ISSN 0014-5793. PMID 8543060. 
  7. ^ Arthur, William T; Ellerbroek Shawn M; Der Channing J; Burridge Keith; Wennerberg Krister (Nov 2002). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. United States. 277 (45): 42964–72. doi:10.1074/jbc.M207401200. ISSN 0021-9258. PMID 12221096. 
  8. ^ Zalcman, G; Closson V; Camonis J; Honoré N; Rousseau-Merck M F; Tavitian A; Olofsson B (Nov 1996). "RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. UNITED STATES. 271 (48): 30366–74. doi:10.1074/jbc.271.48.30366. ISSN 0021-9258. PMID 8939998. 
  9. ^ Mircescu, Hortensia; Steuve Séverine; Savonet Valérie; Degraef Chantal; Mellor Harry; Dumont Jacques E; Maenhaut Carine; Pirson Isabelle (Dec 2002). "Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP". Eur. J. Biochem. Germany. 269 (24): 6241–9. doi:10.1046/j.1432-1033.2002.03343.x. ISSN 0014-2956. PMID 12473120. 

Further reading[edit]

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