List of adaptins
There are several types of adaptin, each related to a different complex of such receptors.
Adaptins show sequence similarity to some COPI subunits, thus they are thought to have a common evolutionary origin. The adaptin is a heterotetramer consisting of two large adaptins (beta and one other depending on the complex), a medium adaptin (mu), and a small adaptin (sigma):
- complex 1
- complex 2
- complex 3
- complex 4
- complex 5
A diagram of the 5 complexes is shown here
- Boehm M, and Bonifacino JS|Adaptins The Final Recount|Molecular Biology of the Cell. 2001 Oct; 12(10): 2907–2920. PMCID: PMC60144
- Mattera R, Guardia CM, Sidhu SS, Bonifacino JS, J Biol Chem. 2015 Dec 25;290(52):30736-49. "Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex.". ncbi.nlm.nih.gov. American Society for Biochemistry and Molecular Biology. Retrieved 17 April 2017.
- Alberts, Johnson, Lewis, Raff, Roberts, Walter: Molecular Biology of the Cell, 4th edition (2002), Garland Science.
- Hirst J, D. Barlow L, Francisco GC, Sahlender DA, Seaman MNJ, Dacks JB, et al. (2011) The Fifth Adaptor Protein Complex. PLoS Biol 9(10): e1001170. doi:10.1371/journal.pbio.1001170
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