List of adaptins

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Adaptins are proteins that mediate the formation of vesicles for intracellular trafficking and secretion. Adaptins are clustered subunits of adaptor protein complexes.[1]

There are several types of adaptin, each related to a different complex of such receptors.

Adaptins show sequence similarity to some COPI subunits, thus they are thought to have a common evolutionary origin. The adaptin is a heterotetramer consisting of two large adaptins (beta and one other depending on the complex), a medium adaptin (mu), and a small adaptin (sigma):

A diagram of the 5 complexes is shown here


  1. ^ Boehm M, and Bonifacino JS|Adaptins The Final Recount|Molecular Biology of the Cell. 2001 Oct; 12(10): 2907–2920. PMCID: PMC60144
  2. ^ Mattera R, Guardia CM, Sidhu SS, Bonifacino JS, J Biol Chem. 2015 Dec 25;290(52):30736-49. "Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex.". American Society for Biochemistry and Molecular Biology. Retrieved 17 April 2017. 
  • Alberts, Johnson, Lewis, Raff, Roberts, Walter: Molecular Biology of the Cell, 4th edition (2002), Garland Science.
  • Hirst J, D. Barlow L, Francisco GC, Sahlender DA, Seaman MNJ, Dacks JB, et al. (2011) The Fifth Adaptor Protein Complex. PLoS Biol 9(10): e1001170. doi:10.1371/journal.pbio.1001170