List of adaptins

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Adaptins are proteins that mediate the formation of vesicles by clathrin-coated pits, through interaction with membrane-bound receptors. There are several types of adaptin, each related to a different group of such receptors.

Adaptins show sequence similarity to some COPI subunits, thus they are thought to have a common evolutionary origin.

Adaptins cluster to form the AP2 complex.

The Adaptin complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma):

A diagram of the 5 complexes is shown here


  1. ^ Mattera R, Guardia CM, Sidhu SS, Bonifacino JS, J Biol Chem. 2015 Dec 25;290(52):30736-49. "Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex.". American Society for Biochemistry and Molecular Biology. Retrieved 17 April 2017. 
  • Alberts, Johnson, Lewis, Raff, Roberts, Walter: Molecular Biology of the Cell, 4th edition (2002), Garland Science.
  • Hirst J, D. Barlow L, Francisco GC, Sahlender DA, Seaman MNJ, Dacks JB, et al. (2011) The Fifth Adaptor Protein Complex. PLoS Biol 9(10): e1001170. doi:10.1371/journal.pbio.1001170