Cell adhesion molecule 1

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CADM1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCADM1, BL2, IGSF4, IGSF4A, NECL2, Necl-2, RA175, ST17, SYNCAM, TSLC1, sTSLC-1, sgIGSF, synCAM1, cell adhesion molecule 1
External IDsMGI: 1889272 HomoloGene: 8641 GeneCards: CADM1
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for CADM1
Genomic location for CADM1
Band11q23.3Start115,169,218 bp[1]
End115,504,957 bp[1]
RNA expression pattern
PBB GE CADM1 209032 s at fs.png

PBB GE CADM1 209030 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001098517
NM_001301043
NM_001301044
NM_001301045
NM_014333

NM_001025600
NM_018770
NM_207675
NM_207676
NM_001310841

RefSeq (protein)

NP_001091987
NP_001287972
NP_001287973
NP_001287974
NP_055148

NP_001020771
NP_001297770
NP_061240
NP_997558
NP_997559

Location (UCSC)Chr 11: 115.17 – 115.5 MbChr 9: 47.53 – 47.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cell adhesion molecule 1 is a protein that, in humans, is encoded by the CADM1 gene.[5][6]

Model organisms[edit]

Model organisms have been used in the study of CADM1 function. A conditional knockout mouse line, called Cadm1tm1.2Brd[10] was generated.[11] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][12] Twenty six tests were carried out on homozygous mutant mice and one significant abnormality was observed: males were infertile.[9] Further analysis showed spermatogenesis had arrested in these mice.[11]

Interactions[edit]

Cell adhesion molecule 1 has been shown to interact with EPB41L3.[13]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182985 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032076 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Gomyo H, Arai Y, Tanigami A, Murakami Y, Hattori M, Hosoda F, Arai K, Aikawa Y, Tsuda H, Hirohashi S, Asakawa S, Shimizu N, Soeda E, Sakaki Y, Ohki M (Feb 2000). "A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2". Genomics. 62 (2): 139–46. doi:10.1006/geno.1999.6001. PMID 10610705.
  6. ^ "Entrez Gene: CADM1 cell adhesion molecule 1".
  7. ^ "Salmonella infection data for Cadm1". Wellcome Trust Sanger Institute.
  8. ^ "Citrobacter infection data for Cadm1". Wellcome Trust Sanger Institute.
  9. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  10. ^ "Mouse Genome Informatics".
  11. ^ a b Van Der Weyden, L.; Arends, M. J.; Chausiaux, O. E.; Ellis, P. J.; Lange, U. C.; Surani, M. A.; Affara, N.; Murakami, Y.; Adams, D. J.; Bradley, A. (2006). "Loss of TSLC1 Causes Male Infertility Due to a Defect at the Spermatid Stage of Spermatogenesis". Molecular and Cellular Biology. 26 (9): 3595–3609. doi:10.1128/MCB.26.9.3595-3609.2006. PMC 1447413. PMID 16611999.
  12. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
  13. ^ Yageta, Mika; Kuramochi Masami; Masuda Mari; Fukami Takeshi; Fukuhara Hiroshi; Maruyama Tomoko; Shibuya Masabumi; Murakami Yoshinori (Sep 2002). "Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer". Cancer Res. 62 (18): 5129–33. ISSN 0008-5472. PMID 12234973.

Further reading[edit]