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Available structures
PDBOrtholog search: PDBe RCSB
AliasesIL17RB, CRL4, EVI27, IL17BR, IL17RH1, interleukin 17 receptor B
External IDsMGI: 1355292 HomoloGene: 10287 GeneCards: IL17RB
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for IL17RB
Genomic location for IL17RB
Band3p21.1Start53,846,580 bp[1]
End53,865,800 bp[1]
RNA expression pattern
PBB GE IL17RB 219255 x at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 3: 53.85 – 53.87 MbChr 14: 30 – 30.01 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Interleukin-17 receptor B is a protein that in humans is encoded by the IL17RB gene.[5][6][7]

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17(A) or IL17C. This receptor has been shown to mediate the activation of NF-κB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.[7]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000056736 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015966 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber MC, Wang W, Wathen K, Hodge V, Fisher CL, Olsen H, Ruben SM, Knyazev I, Cho YH, Kao V, Wilkinson KA, Carrell JA, Ebner R (Aug 2000). "A novel cytokine receptor-ligand pair. Identification, molecular Aaron 9 ok ò charkacterization, and in vivo immunomodulatory activity". J Biol Chem. 275 (25): 19167–76. doi:10.1074/jbc.M910228199. PMID 10749887. 
  6. ^ Tian E, Sawyer JR, Largaespada DA, Jenkins NA, Copeland NG, Shaughnessy JD Jr (Jun 2000). "Evi27 encodes a novel membrane protein with homology to the IL17 receptor". Oncogene. 19 (17): 2098–109. doi:10.1038/sj.onc.1203577. PMID 10815801. 
  7. ^ a b "Entrez Gene: IL17RB interleukin 17 receptor B". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.