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Indometacin farnesil AHFS /Drugs.com International Drug Names Routes of administration Oral ATC code Legal status
In general: ℞ (Prescription only)
Metabolism To indometacin Elimination half-life 1.5 hours Excretion Renal
(2E ,6E )-3,7,11-trimethyldodeca-2,6,10-trien-1-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H -indol-3-yl]acetate
CAS Number PubChem CID ChemSpider CompTox Dashboard (EPA ) ECHA InfoCard 100.242.585 Formula C 34 H 40 Cl N O 4 Molar mass 562.14 g/mol g·mol−1 3D model (JSmol )
CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)OCC=C(C)CCC=C(C)CCC=C(C)C
InChI=1S/C34H40ClNO4/c1-23(2)9-7-10-24(3)11-8-12-25(4)19-20-40-33(37)22-30-26(5)36(32-18-17-29(39-6)21-31(30)32)34(38)27-13-15-28(35)16-14-27/h9,11,13-19,21H,7-8,10,12,20,22H2,1-6H3/b24-11+,25-19+
Y Key:CFIGYZZVJNJVDQ-LMJOQDENSA-N
Y
(verify)
Indometacin farnesil (INN ) is a prodrug of the non-steroidal anti-inflammatory drug indometacin , designed to reduce the occurrence of side-effects by esterification of the carboxyl group on indometacin with farnesol . Indometacin farnesil was first approved in Japan in 1991, and is available in Japan and Indonesia , under the trade names Infree and Dialon , respectively.
External links
Receptor (ligands )
DP (D2 ) Tooltip Prostaglandin D2 receptor
DP1 Tooltip Prostaglandin D2 receptor 1 DP2 Tooltip Prostaglandin D2 receptor 2
EP (E2 ) Tooltip Prostaglandin E2 receptor
EP1 Tooltip Prostaglandin EP1 receptor EP2 Tooltip Prostaglandin EP2 receptor EP3 Tooltip Prostaglandin EP3 receptor EP4 Tooltip Prostaglandin EP4 receptor Unsorted
FP (F2α ) Tooltip Prostaglandin F receptor IP (I2 ) Tooltip Prostacyclin receptor TP (TXA2 ) Tooltip Thromboxane receptor Unsorted
Enzyme (inhibitors )
COX (PTGS )PGD2 S Tooltip Prostaglandin D synthase PGES Tooltip Prostaglandin E synthase PGFS Tooltip Prostaglandin F synthase PGI2 S Tooltip Prostacyclin synthase TXAS Tooltip Thromboxane A synthase
Others