Jump to content

Masoprocol

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by DePiep (talk | contribs) at 17:52, 2 April 2016 (Remove redundant parameters InChI, InChIKey (StdInChI, StdInChIKey are used). See Talk (via AWB script)). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Masoprocol
Clinical data
Trade namesActinex
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration
Topical
ATC code
Pharmacokinetic data
BioavailabilityVery low
Identifiers
  • 4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.044.172 Edit this at Wikidata
Chemical and physical data
FormulaC18H22O4
Molar mass302.365 g/mol g·mol−1
3D model (JSmol)
  • Oc1ccc(cc1O)C[C@H](C)[C@H](C)Cc2ccc(O)c(O)c2
  • InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+ checkY
  • Key:HCZKYJDFEPMADG-TXEJJXNPSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. A form of nordihydroguaiaretic acid that is taken by mouth is being studied in the treatment of prostate cancer.

Also called nordihydroguaiaretic acid, NDGA, and actinex.

Mechanism

Nordihydroguaiaretic acid is an antioxidant, and it may block certain enzymes needed for tumor growth.

It is a lipoxygenase inhibitor.[1]

References

  1. ^ "Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL". Am. J. Physiol. Endocrinol. Metab. 279 (3): E593–600. September 2000. PMID 10950827.