Jump to content

miR-150

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by NickW557 (talk | contribs) at 03:30, 8 June 2016 (Undid revision 724254635 by 130.216.139.149 (talk) fringe / user blocked). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

miR-150
Conserved secondary structure of miR-150 microRNA precursor
Identifiers
SymbolmiR-150
Alt. SymbolsMIR150
RfamRF00767
miRBaseMI0000479
miRBase familyMIPF0000197
NCBI Gene406942
HGNC31537
OMIM610566
RefSeqNR_029703
Other data
RNA typemiRNA
Domain(s)Mammalia
GO0035195
SO0001244
LocusChr. 19 q13.33
PDB structuresPDBe

miR-150 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] This sequence then associates with RISC which effects RNA interference.[2]

miR-150 functions in hematopoiesis; it regulates genes whose downstream products encourage differentiating stem cells towards becoming megakaryocytes rather than erythrocytes.[3][4] It is also thought to control B and T cell differentiation, alongside mir-155.[5][6]

Expression

The expression pattern of miR-150 varies during the differentiation of a hematopoietic stem cell lineage. Highest expression levels occur in mature, resting B and T cells but miR-150 is downregulated in their progenitor cells, including Th1 and Th2 cells.[5]

Role in cancer

miR-150 has been linked with a number of cancers. It is thought to promote cancer cell proliferation in gastric cancer and has also been found to be more than 50x overexpressed in osteosarcoma.[7] The expression of miR-150 was shown to regulate levels of GAB1 and FOXP1 proteins in malignant and normal B cells, and this influences their BCR signalling [8]

Applications

miR-150 levels in blood plasma can be indicative of early sepsis; it could have a future use therapeutically in treating the condition.[9] In addition, miR-150 is one of a number of microRNAs whose expression profile could be used as a biomarker of hepatocellular carcinoma.[10]

References

  1. ^ Ambros V (Dec 2001). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823–6. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
  2. ^ Gregory RI, Chendrimada TP, Cooch N, Shiekhattar R (Nov 2005). "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing". Cell. 123 (4): 631–40. doi:10.1016/j.cell.2005.10.022. PMID 16271387.
  3. ^ Lu J, Guo S, Ebert BL, Zhang H, Peng X, Bosco J, Pretz J, Schlanger R, Wang JY, Mak RH, Dombkowski DM, Preffer FI, Scadden DT, Golub TR (Jun 2008). "MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors". Developmental Cell. 14 (6): 843–53. doi:10.1016/j.devcel.2008.03.012. PMC 2688789. PMID 18539114.
  4. ^ Edelstein LC, Bray PF (May 2011). "MicroRNAs in platelet production and activation". Blood. 117 (20): 5289–96. doi:10.1182/blood-2011-01-292011. PMC 3109704. PMID 21364189.
  5. ^ a b Vasilatou D, Papageorgiou S, Pappa V, Papageorgiou E, Dervenoulas J (Jan 2010). "The role of microRNAs in normal and malignant hematopoiesis". European Journal of Haematology. 84 (1): 1–16. doi:10.1111/j.1600-0609.2009.01348.x. PMID 19744129.
  6. ^ Garzon R, Croce CM (Jul 2008). "MicroRNAs in normal and malignant hematopoiesis". Current Opinion in Hematology. 15 (4): 352–8. doi:10.1097/MOH.0b013e328303e15d. PMID 18536574.
  7. ^ Lulla RR, Costa FF, Bischof JM, Chou PM, Bonaldo MF, Vanin EF, Soares MB (2011). "Identification of Differentially Expressed MicroRNAs in Osteosarcoma". Sarcoma. 2011: 732690. doi:10.1155/2011/732690. PMC 3140035. PMID 21789031.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  8. ^ Mraz M, Chen L, Rassenti LZ, Ghia EM, Li H, Jepsen K, Smith EN, Messer K, Frazer KA, Kipps TJ (Jul 2014). "miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1". Blood. 124 (1): 84–95. doi:10.1182/blood-2013-09-527234. PMID 24787006.
  9. ^ Vasilescu C, Rossi S, Shimizu M, Tudor S, Veronese A, Ferracin M, Nicoloso MS, Barbarotto E, Popa M, Stanciulea O, Fernandez MH, Tulbure D, Bueso-Ramos CE, Negrini M, Calin GA (2009-10-12). Gold JA (ed.). "MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis". PLOS ONE. 4 (10): e7405. doi:10.1371/journal.pone.0007405. PMC 2756627. PMID 19823581.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  10. ^ Magrelli A, Azzalin G, Salvatore M, Viganotti M, Tosto F, Colombo T, Devito R, Di Masi A, Antoccia A, Lorenzetti S, Maranghi F, Mantovani A, Tanzarella C, Macino G, Taruscio D (Aug 2009). "Altered microRNA Expression Patterns in Hepatoblastoma Patients". Translational Oncology. 2 (3): 157–63. PMC 2730135. PMID 19701500.

Further reading