Ectodysplasin-A receptor-associated adapter protein is a protein that in humans is encoded by the EDARADDgene.
This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
^Yan, Minhong; Zhang Zemin, Brady John Ridgway, Schilbach Sarah, Fairbrother Wayne J, Dixit Vishva M (Mar 2002). "Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice". Curr. Biol. (England) 12 (5): 409–13. doi:10.1016/S0960-9822(02)00687-5. ISSN0960-9822. PMID11882293.Cite uses deprecated parameters (help)
Yan M, Zhang Z, Brady JR, et al. (2002). "Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice". Curr. Biol.12 (5): 409–13. doi:10.1016/S0960-9822(02)00687-5. PMID11882293.
Kumar A, Eby MT, Sinha S, et al. (2001). "The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A". J. Biol. Chem.276 (4): 2668–77. doi:10.1074/jbc.M008356200. PMID11035039.